2007
Altered Natural Killer Cells in Type 1 Diabetic Patients
Rodacki M, Svoren B, Butty V, Besse W, Laffel L, Benoist C, Mathis D. Altered Natural Killer Cells in Type 1 Diabetic Patients. Diabetes 2007, 56: 177-185. PMID: 17192480, DOI: 10.2337/db06-0493.Peer-Reviewed Original ResearchConceptsType 1 diabetesBlood NK cellsType 1 diabetic patientsNK cellsNatural killer cellsDiabetic patientsNatural killerControl subjectsReduced activity of NK cellsKiller cellsDecreased expression of NKG2DActivity of NK cellsPatients relative to control subjectsDevelopment of type 1 diabetesHuman type 1 diabetesEarly onset of diabetesExpression of NKG2DType 1 diabetes pathogenesisGamma interferon expressionDuration of diseaseKIR gene haplotypesOnset of diabetesKIR2DS3 geneNOD miceGamma interferon
2005
Variation in IL-1β gene expression is a major determinant of genetic differences in arthritis aggressivity in mice
Ohmura K, Johnsen A, Ortiz-Lopez A, Desany P, Roy M, Besse W, Rogus J, Bogue M, Puech A, Lathrop M, Mathis D, Benoist C. Variation in IL-1β gene expression is a major determinant of genetic differences in arthritis aggressivity in mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 12489-12494. PMID: 16113081, PMCID: PMC1194932, DOI: 10.1073/pnas.0504325102.Peer-Reviewed Original ResearchConceptsInbred strainsWhole-genome scanQuantitation of transcriptsInterleukin-1 gene familyConventional inbred strainsWild-derived strainsComplex genetic controlSequence haplotypesGenomic regionsGenetic lociNoncoding polymorphismsCandidate genesGenetic analysisGenetic differencesBALB/c haplotypeGenetic controlGene expressionIL-1B gene expressionBreeding strategiesBreeding schemesIL1B geneGenesSerum-transfer arthritisStrainHigh-responder BALB/c