2018
Glucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta‐analysis
Kucukgoncu S, Kosir U, Zhou E, Sullivan E, Srihari VH, Tek C. Glucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta‐analysis. Early Intervention In Psychiatry 2018, 13: 1021-1031. PMID: 30277314, PMCID: PMC6445792, DOI: 10.1111/eip.12749.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisSevere mental illnessGlucose metabolism outcomesTreatment-naïveEpisode psychosisMood disordersMental illnessSystematic reviewGlucose tolerance test resultsInsulin resistance levelsImpaired glucose metabolismFirst-episode patientsTolerance test resultsHigh-risk groupMood disorder groupGlucose intoleranceEpisode patientsDiabetes developmentMetabolism dysregulationEligible studiesHealthy controlsHigh insulinFEP groupGlucose metabolismPatients
2015
Equivalent mismatch negativity deficits across deviant types in early illness schizophrenia-spectrum patients
Hay RA, Roach BJ, Srihari VH, Woods SW, Ford JM, Mathalon DH. Equivalent mismatch negativity deficits across deviant types in early illness schizophrenia-spectrum patients. Biological Psychology 2015, 105: 130-137. PMID: 25603283, PMCID: PMC4336819, DOI: 10.1016/j.biopsycho.2015.01.004.Peer-Reviewed Original ResearchConceptsSchizophrenia spectrum patientsHealthy controlsEarly schizophrenia patientsMMN amplitude reductionDuration of illnessCourse of schizophreniaMismatch negativityDeviant typesMismatch negativity deficitsClinical symptomsDifferent deviant typesNeurophysiological abnormalitiesAuditory deviantsSchizophrenia patientsPatientsAuditory deviance processingIllnessNeurophysiological mechanismsAmplitude reductionSignificant interactionMMN responsesDeviance processingSymptomsAbnormalitiesSchizophrenia
2013
Deficient Suppression of Default Mode Regions during Working Memory in Individuals with Early Psychosis and at Clinical High-Risk for Psychosis
Fryer SL, Woods SW, Kiehl KA, Calhoun VD, Pearlson GD, Roach BJ, Ford JM, Srihari VH, McGlashan TH, Mathalon DH. Deficient Suppression of Default Mode Regions during Working Memory in Individuals with Early Psychosis and at Clinical High-Risk for Psychosis. Frontiers In Psychiatry 2013, 4: 92. PMID: 24032017, PMCID: PMC3768116, DOI: 10.3389/fpsyt.2013.00092.Peer-Reviewed Original ResearchHealthy controlsDefault mode networkPsychosis onsetDMN regionsSeed-based connectivity analysisEarly schizophrenia patientsDMN suppressionClinical high riskLoad-dependent increaseMedial prefrontal cortexPosterior DMN nodesSuppression of activityPosterior parietal cortexResting-state fMRI dataDorsolateral prefrontal cortex activationDeficient suppressionESZ groupsESZ patientsPrefrontal cortex activationHigh riskEarly psychosisSchizophrenia patientsCHR individualsCortex activationLoad-dependent modulationChapter 10 Early auditory gamma-band responses in patients at clinical high risk for schizophrenia
Perez VB, Roach BJ, Woods SW, Srihari VH, McGlashan TH, Ford JM, Mathalon DH. Chapter 10 Early auditory gamma-band responses in patients at clinical high risk for schizophrenia. Supplements To Clinical Neurophysiology 2013, 62: 147-162. PMID: 24053038, PMCID: PMC4120874, DOI: 10.1016/b978-0-7020-5307-8.00010-7.Peer-Reviewed Original ResearchConceptsClinical high riskPhase-locking factorGamma-band responseAuditory gamma-band responsesCHR patientsHigh riskSchizophrenia patientsChronic schizophrenia patientsNMDA glutamate receptorsYounger schizophrenia patientsTransient gamma-band responseTrend-level reductionsNeurotransmission abnormalitiesGamma-band oscillationsYounger patientsIllness onsetProdromal symptomsPhase synchronyProdromal periodHealthy controlsPsychosis onsetPatientsPsychotic disordersCHR groupElectroencephalographic studies
2012
Error Monitoring Dysfunction Across the Illness Course of Schizophrenia
Perez VB, Ford JM, Roach BJ, Woods SW, McGlashan TH, Srihari VH, Loewy RL, Vinogradov S, Mathalon DH. Error Monitoring Dysfunction Across the Illness Course of Schizophrenia. Journal Of Psychopathology And Clinical Science 2012, 121: 372-387. PMID: 22060947, PMCID: PMC3358508, DOI: 10.1037/a0025487.Peer-Reviewed Original ResearchConceptsEarly illness schizophrenia patientsClinical high-risk patientsSchizophrenia patientsIllness courseAge-matched healthy controlsHigh-risk patientsAge-matched HCChronic schizophrenia patientsOnset of psychosisCorrect response negativityPE abnormalitiesRisk patientsCHR patientsClinical prodromeEvent-related potentialsIllness durationHealthy controlsIllness progressionPsychosis onsetPatientsAbnormalitiesIllnessResponse monitoringError-related negativityOnset