2024
TimelinePTC: Development of a unified interface for pathways to care collection, visualization, and collaboration in first episode psychosis
Mathis W, Ferrara M, Cahill J, Karmani S, Tayfur S, Srihari V. TimelinePTC: Development of a unified interface for pathways to care collection, visualization, and collaboration in first episode psychosis. PLOS ONE 2024, 19: e0302116. PMID: 39028697, PMCID: PMC11259254, DOI: 10.1371/journal.pone.0302116.Peer-Reviewed Original ResearchConceptsPathways to CareDuration of untreated psychosisManual transcription errorsDevelopment of targeted interventionsReduce duration of untreated psychosisHealthcare accessibility researchReal-time data entryImprove patient outcomesEpisode psychosisCare pathwaysPatient journeyHealthcare contextPatient outcomesPaper-basedConversion of collected dataFEP treatmentData collection processNew HavenData collection methodsData entryTranscription errorsUntreated psychosisOpen-source codebaseData collectionWeb-based toolThe Italian adaptation of the Mini‐SIPS, a tool for early detection of individuals at clinical high risk and first episode of psychosis: A preliminary study of implementation in an Italian FEP program
Ferrara M, Basaldella M, Vacca F, Woods S, Walsh B, Cannon T, Srihari V, Grassi L. The Italian adaptation of the Mini‐SIPS, a tool for early detection of individuals at clinical high risk and first episode of psychosis: A preliminary study of implementation in an Italian FEP program. Early Intervention In Psychiatry 2024 PMID: 38769052, DOI: 10.1111/eip.13548.Peer-Reviewed Original ResearchClinical high riskFirst-episode psychosisDSM-5-Attenuated Psychosis SyndromeItalian adaptationPsychosis syndromeDSM-5FEP programsEarly stages of psychosisItalian versionFirst-episode psychosis servicesFull-blown psychosisStages of psychosisEpisode of psychosisClinical structured interviewEpisode psychosisEstablished psychosisTrained psychologistsPsychiatric historyPsychosisPsychosis servicesHigh riskStructured interviewsClinical settingEarly detection of individualsAssess validityAntipsychotic drugs in first-episode psychosis: a target trial emulation in the FEP-CAUSAL Collaboration
Szmulewicz A, Martínez-Alés G, Logan R, Ferrara M, Kelly C, Fredrikson D, Gago J, Conderino S, Díaz-Caneja C, Galvañ J, Thorpe L, Srihari V, Yatham L, Sarpal D, Shinn A, Arango C, Öngür D, Hernán M, Collaboration O. Antipsychotic drugs in first-episode psychosis: a target trial emulation in the FEP-CAUSAL Collaboration. American Journal Of Epidemiology 2024, 193: 1081-1087. PMID: 38576166, DOI: 10.1093/aje/kwae029.Peer-Reviewed Original ResearchFirst-episode psychosisFirst-generation agentsAntipsychotic therapyAntipsychotic drugsPsychosis onsetPsychotic disordersEpisode psychosisAripiprazolePaliperidoneRisk of hospitalizationPsychosisTarget trialsRisperidoneOlanzapineFirst-line therapyTreatment discontinuationEUFESTObservational cohortAntipsychoticsQuetiapineRandomized trialsPrimary outcomeAbsolute riskRisk differenceClinical questions
2023
579. Benchmarking Observational Analyses Against Randomized Trial Results: An Application to First Episode Psychosis
Szmulewicz A, Martinez-Ales G, Ferrara M, Fredrikson D, Gago J, Srihari V, Yatham L, Conderino S, Shinn A, Ongur D, Hernán M. 579. Benchmarking Observational Analyses Against Randomized Trial Results: An Application to First Episode Psychosis. Biological Psychiatry 2023, 93: s328-s329. DOI: 10.1016/j.biopsych.2023.02.819.Peer-Reviewed Original Research
2021
Establishing the Early Psychosis Intervention Clinic, New Orleans (EPIC-NOLA): Sustainability Challenges Threaten Clinical Success.
Weiss A, Chaudhry S, Cahill JD, Srihari VH. Establishing the Early Psychosis Intervention Clinic, New Orleans (EPIC-NOLA): Sustainability Challenges Threaten Clinical Success. Journal Of Health Care For The Poor And Underserved 2021, 32: 8-17. PMID: 33678676, DOI: 10.1353/hpu.2021.0003.Peer-Reviewed Original Research
2020
Cognitive Effort and Amotivation in First-Episode Psychosis
Fortgang RG, Srihari V, Cannon TD. Cognitive Effort and Amotivation in First-Episode Psychosis. Journal Of Psychopathology And Clinical Science 2020, 129: 422-431. PMID: 32162929, DOI: 10.1037/abn0000509.Peer-Reviewed Original ResearchConceptsCognitive effortFirst-episode psychosisCognitive test performanceObserved cognitive deficitsAdditional monetary incentivesCognitive remediationCognitive tasksCognitive performanceDifficult trialsNovel taskCognitive deficitsAmotivationImpaired cognitionTest performanceCore featuresDisengagementLower overall accuracyHealthy community membersMonetary incentivesCurrent studyEpisode psychosisFEP patientsPsychotic disordersReduced effortTask
2019
Early intervention service for first episode psychosis in Modena, Northern Italy: The first hundred cases
Ferrara M, Tedeschini E, Baccari F, Musella V, Vacca F, Mazzi F, Ferri M, Srihari V, Starace F, Group F. Early intervention service for first episode psychosis in Modena, Northern Italy: The first hundred cases. Early Intervention In Psychiatry 2019, 13: 1011-1017. PMID: 30672134, DOI: 10.1111/eip.12788.Peer-Reviewed Original ResearchConceptsEarly intervention servicesClinical improvementMedian ageIntervention servicesCommunity mental health centerCommunity outpatient servicesPsychiatric hospital unitMeaningful clinical improvementFirst-episode psychosisModel of careNon-affective psychosisNation Outcome ScalesMental health centersHigher median ageEarly detection effortsRefinement of treatmentMain referralsPharmacological consultationYounger patientsUntreated psychosisOutcome ScaleGeneral practitionersEpisode psychosisHealth centersOutpatient services
2018
Development and validation of the client engagement and service use scale: A pilot study
Kline ER, DeTore NR, Keefe K, Seidman LJ, Srihari VH, Keshavan MS, Guyer M. Development and validation of the client engagement and service use scale: A pilot study. Schizophrenia Research 2018, 201: 343-346. PMID: 29764759, DOI: 10.1016/j.schres.2018.05.006.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisEpisode psychosisService utilizationPilot studyService Engagement ScaleMultiple intervention componentsClients' service utilizationClient engagementMedication adherenceSpecialty careEarly treatmentInter-rater reliabilitySession attendanceHigh inter-rater reliabilityTreatment teamIntervention componentsSpecialized treatmentMenu of servicesPreliminary evidenceCliniciansPsychosisConsumer advocacy groupsUse ScaleTreatmentMinimal trainingGlucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta‐analysis
Kucukgoncu S, Kosir U, Zhou E, Sullivan E, Srihari VH, Tek C. Glucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta‐analysis. Early Intervention In Psychiatry 2018, 13: 1021-1031. PMID: 30277314, PMCID: PMC6445792, DOI: 10.1111/eip.12749.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisSevere mental illnessGlucose metabolism outcomesTreatment-naïveEpisode psychosisMood disordersMental illnessSystematic reviewGlucose tolerance test resultsInsulin resistance levelsImpaired glucose metabolismFirst-episode patientsTolerance test resultsHigh-risk groupMood disorder groupGlucose intoleranceEpisode patientsDiabetes developmentMetabolism dysregulationEligible studiesHealthy controlsHigh insulinFEP groupGlucose metabolismPatientsAn Economic Evaluation of Coordinated Specialty Care (CSC) Services for First-Episode Psychosis in the U.S. Public Sector.
Murphy SM, Kucukgoncu S, Bao Y, Li F, Tek C, Breitborde NJK, Guloksuz S, Phutane VH, Ozkan B, Pollard JM, Cahill JD, Woods SW, Cole RA, Schoenbaum M, Srihari VH. An Economic Evaluation of Coordinated Specialty Care (CSC) Services for First-Episode Psychosis in the U.S. Public Sector. The Journal Of Mental Health Policy And Economics 2018, 21: 123-130. PMID: 30530872, PMCID: PMC6314808.Peer-Reviewed Original ResearchConceptsSpecialty care servicesPatient costsEarly intervention servicesUsual treatmentSchizophrenia spectrum disordersMonth 12Economic evaluationCare servicesSTEP participantsCommunity mental health centerThird-party payer perspectiveIntervention servicesFirst-episode servicesMonths post randomizationHealthcare service utilizationMental health centersU.S. public sectorTeam-based careCost-offset analysisEligible patientsThird-party payersAntipsychotic exposureED visitsMonth 6Episode psychosis
2017
First-Episode Psychosis and the Criminal Justice System: Using a Sequential Intercept Framework to Highlight Risks and Opportunities
Wasser T, Pollard J, Fisk D, Srihari V. First-Episode Psychosis and the Criminal Justice System: Using a Sequential Intercept Framework to Highlight Risks and Opportunities. Psychiatric Services 2017, 68: 994-996. PMID: 28859587, DOI: 10.1176/appi.ps.201700313.Peer-Reviewed Original ResearchConceptsCriminal justice systemJustice systemSubsequent criminal justice involvementSequential Intercept ModelCriminal justice involvementCriminal justiceLegal outcomesDiversionary programsCaseload burdenHighlight risksJustice involvementClinical sphereIntercept modelFirst-episode psychosisMental health servicesJusticeEpisode psychosisHealth servicesRisk of aggressionSpherePsychosisRiskOpportunitiesFrameworkPatients