1999
Inhibition of neurotransmitter release in the lamprey reticulospinal synapse by antibody-mediated disruption of SNAP-25 function
Low P, Norlin T, Risinger C, Larhammar D, Pieribone V, Shupliakov O, Brodin L. Inhibition of neurotransmitter release in the lamprey reticulospinal synapse by antibody-mediated disruption of SNAP-25 function. European Journal Of Cell Biology 1999, 78: 787-793. PMID: 10604655, DOI: 10.1016/s0171-9335(99)80029-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalAxonsCell MembraneImmunohistochemistryIn Situ HybridizationLampreysMembrane ProteinsMicroinjectionsMicroscopy, ElectronNerve Tissue ProteinsNeurotransmitter AgentsProtein BindingRecombinant Fusion ProteinsSpinal CordSynapsesSynaptic TransmissionSynaptic VesiclesSynaptosomal-Associated Protein 25ConceptsPlasma membraneSynaptic vesiclesSNAP-25Lamprey giant reticulospinal synapsePresynaptic plasma membraneSynaptic vesicle exocytosisLamprey reticulospinal synapseSNARE protein SNAP-25Protein SNAP-25Synaptic vesicle clustersNeurotransmitter releaseSNARE complexMolecular machineryVesicle exocytosisMembrane fusionVesicle cyclingPresynaptic microinjectionVesicle clustersSyntaxinPresynaptic membraneVesiclesElectron microscopic analysisAntibody-mediated disruptionMembraneMicroscopic analysisSynapsins as regulators of neurotransmitter release
Hilfiker S, Pieribone V, Czernik A, Kao H, Augustine G, Greengard P. Synapsins as regulators of neurotransmitter release. Philosophical Transactions Of The Royal Society B Biological Sciences 1999, 354: 269-279. PMID: 10212475, PMCID: PMC1692497, DOI: 10.1098/rstb.1999.0378.Peer-Reviewed Original ResearchConceptsSynapsin functionSynaptic vesiclesSynaptic vesicle life cycleReserve poolNeuron-specific phosphoproteinNeurotransmitter releaseSelective disruptionVesicle dockingMultigene familyNumerous proteinsCytoskeletal meshworkAbundant proteinsCytoskeletal proteinsMolecular mechanismsProtein componentsSynapsinSynapse formationPresynaptic nerve terminalsVesiclesProteinSecond roleRelease of neurotransmittersLife cycleCurrent understandingSquid giant synapse
1997
Sustained Neurotransmitter Release: New Molecular Clues
Brodin L, Löw P, Gad H, Gustafsson J, Pieribone V, Shupliakov O. Sustained Neurotransmitter Release: New Molecular Clues. European Journal Of Neuroscience 1997, 9: 2503-2511. PMID: 9517455, DOI: 10.1111/j.1460-9568.1997.tb01679.x.Peer-Reviewed Original Research
1995
Distinct pools of synaptic vesicles in neurotransmitter release
Pieribone V, Shupliakov O, Brodin L, Hilfiker-Rothenfluh S, Czernik A, Greengard P. Distinct pools of synaptic vesicles in neurotransmitter release. Nature 1995, 375: 493-497. PMID: 7777058, DOI: 10.1038/375493a0.Peer-Reviewed Original ResearchConceptsNeurotransmitter releaseCellular secretory systemSynaptic vesiclesLow-frequency stimulationSynaptic release sitesRelease of neurotransmittersHigh-frequency burstsNeuron-specific proteinSynapsin antibodiesPool of vesiclesDistal poolNerve terminalsMarked depressionVesicular releasePresynaptic membraneSynapsinHigh rateClusters of vesiclesApparent effectReleaseSecretory systemSuch protein familiesNeurotransmittersRelease sites
1992
COLOCALIZATION OF NEUROPEPTIDES AND CLASSICAL NEUROTRANSMITTERS - FUNCTIONAL SIGNIFICANCE.
HÖKFELT T, ARVIDSSON U, BEAN A, CASTEL M, CECCATELLI S, DAGERLIND Å, ELDE R, MEISTER B, MORINO P, NICHOLAS A, PELTO-HUIKKO M, PIERIBONE V, SCHALLING M, VERGE V, XU Z, RTFAI T, WIESENFELD-HALLIN Z. COLOCALIZATION OF NEUROPEPTIDES AND CLASSICAL NEUROTRANSMITTERS - FUNCTIONAL SIGNIFICANCE. Clinical Neuropharmacology 1992, 15: 309a. PMID: 1354037, DOI: 10.1097/00002826-199201001-00160.Peer-Reviewed Original Research
1991
Chapter 4 Afferent regulation of locus coeruleus neurons: anatomy, physiology and pharmacology
Aston-Jones G, Shipley MT, Chouvet G, Ennis M, van Bockstaele E, Pieribone V, Shiekhattar R, Akaoka H, Drolet G, Astier B, Charléty P, Valentino R, Williams J. Chapter 4 Afferent regulation of locus coeruleus neurons: anatomy, physiology and pharmacology. Progress In Brain Research 1991, 88: 47-75. PMID: 1687622, DOI: 10.1016/s0079-6123(08)63799-1.Peer-Reviewed Original ResearchMeSH KeywordsAfferent PathwaysAnimalsHypothalamusLocus CoeruleusNeurotransmitter AgentsPeriaqueductal GrayRatsReceptors, NeurotransmitterSympathetic Nervous SystemConceptsLC neuronsLocus coeruleusLC dendritesPericoerulear regionCaudal medullary reticular formationExcitatory amino acid inputsSensory responsesCertain hypothalamic areasLocus coeruleus neuronsNon-NMDA receptorsMedullary reticular formationSingle-pulse stimulationCorticotropin-releasing factorNucleus prepositus hypoglossiDouble-labeling studiesNucleus locus coeruleusVariety of neurotransmittersKölliker-Fuse nucleusMagnesium-free solutionAmino acid inputMinor afferentsPericoerulear areaPerifascicular areasPGi neuronsAdrenergic inhibition