Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration
Fang Y, Gupta V, Karra R, Holdway JE, Kikuchi K, Poss KD. Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 13416-13421. PMID: 23901114, PMCID: PMC3746860, DOI: 10.1073/pnas.1309810110.Peer-Reviewed Original ResearchConceptsHeart regenerationSTAT3 inhibitionCertain lower vertebratesZebrafish heart regenerationRibosome affinity purificationTranslational profilingProgram essentialLower vertebratesAffinity purificationPathway membersSTAT3-dependent mannerZebrafish cardiomyocytesCardiomyocyte proliferationAnimal growthInjury-induced proliferationDynamic inductionProliferationCardiomyocytesInjury responseRegenerationRln3aVertebratesCardiogenesisRNAInhibition