2023
The Relationship Between Acute Dissociative Effects Induced by Ketamine and Treatment Response in Adolescent Patients with Treatment-Resistant Depression
Lineham A, Avila-Quintero V, Bloch M, Dwyer J. The Relationship Between Acute Dissociative Effects Induced by Ketamine and Treatment Response in Adolescent Patients with Treatment-Resistant Depression. Journal Of Child And Adolescent Psychopharmacology 2023, 33: 20-26. PMID: 36799961, DOI: 10.1089/cap.2022.0086.Peer-Reviewed Original ResearchConceptsTreatment-resistant depressionDepression symptom improvementAcute dissociative symptomsAntidepressant responseSymptom improvementRapid-acting antidepressant agentsSignificant associationDissociative symptomsLikelihood of responseDissociation symptomsMagnitude of associationDissociative effectsKetamine groupPediatric patientsCrossover trialPediatric populationAntidepressant agentsKetamine responseAdolescent patientsAdult studiesDepression responseSecondary data analysisTreatment responseDepressive symptomsTrial designSystematic review and meta-analysis: Season of birth and schizophrenia risk
Coury S, Lombroso A, Avila-Quintero V, Taylor J, Flores J, Szejko N, Bloch M. Systematic review and meta-analysis: Season of birth and schizophrenia risk. Schizophrenia Research 2023, 252: 244-252. PMID: 36682315, DOI: 10.1016/j.schres.2022.12.016.Peer-Reviewed Original ResearchConceptsRisk of schizophreniaSummer birthWinter birthSystematic reviewBirth monthVitamin D deficiencyStratified subgroup analysisSchizophrenia riskEtiological risk factorsMonth of birthD deficiencySeason of birthEtiologic causesSubgroup analysisVirus exposureRisk factorsSchizophreniaMonthsBirthSignificant differencesRiskAssociationAssociation Between Patient Race and Ethnicity and Outcomes With COVID-19: A Retrospective Analysis From a Large Mid-Atlantic Health System
Rao A, Alnababteh M, Avila-Quintero V, Flores J, Laing N, Boyd D, Yu J, Ahmed N, Groninger H, Zaaqoq A. Association Between Patient Race and Ethnicity and Outcomes With COVID-19: A Retrospective Analysis From a Large Mid-Atlantic Health System. Journal Of Intensive Care Medicine 2023, 38: 472-478. PMID: 36594202, PMCID: PMC9813659, DOI: 10.1177/08850666221149956.Peer-Reviewed Original ResearchConceptsHispanic patientsWhite patientsClinical outcomesMechanical ventilationAverage ageSevere COVID-19 infectionRetrospective cohort studyCOVID-19 pneumoniaOdds of deathPatient demographic dataCOVID-19 infectionNon-Hispanic blacksCOVID-19Non-Hispanic whitesElectronic health recordsCohort studyPatient raceDecreased oddsRetrospective analysisProfit healthcare systemStudy populationPatientsLower average ageLower mortalityDemographic data
2022
Does the SDMQ-9 Predict Changes in HbA1c Levels? An Ecuadorian Cohort
Bajaña M, Moncayo-Rizzo J, Alvarado-Villa G, Avila-Quintero V. Does the SDMQ-9 Predict Changes in HbA1c Levels? An Ecuadorian Cohort. Medicina 2022, 58: 380. PMID: 35334556, PMCID: PMC8950991, DOI: 10.3390/medicina58030380.Peer-Reviewed Original ResearchConceptsShared-decision makingWorse diabetic controlBody mass indexMajor health problemEcuadorian cohortEndocrinology outpatientsDiabetic controlMass indexTreatment adherencePatient controlsHealth problemsHealth statusElevated levelsSpecific populationsSignificant predictorsHbA1cDiabetesPatientsEducational levelPredict changesPredictorsMore investigationSample sizeHigh levelsLinear regressionCharacteristics of Assaultive Patients Whom Inpatient Psychiatric Staff Report to Law Enforcement
Chaffkin J, Barnes TA, Avila Quintero VJ, Flores JM, Lin E, Wasser T. Characteristics of Assaultive Patients Whom Inpatient Psychiatric Staff Report to Law Enforcement. Psychiatric Services 2022, 73: 768-773. PMID: 35172591, DOI: 10.1176/appi.ps.202100140.Peer-Reviewed Original ResearchConceptsInpatient psychiatric unitPsychiatric unitChronic mental illnessDegree of injuryClinical factorsRegression modelsCertain patientsCriminal justice involvementPsychotic symptomsAssaultive patientsPatient assaultsPatient encountersMental illnessPatientsHospital systemLarger quantitative studyPredictive variablesStaff reportsJustice involvementDescriptive statisticsStaffStaff decisionsMedicationsAdmissionInjurySurgical repair of nasal septal perforations: A systematic review and meta‐analysis
Fermin J, Bui R, McCoul E, Alt J, Avila‐Quintero V, Chang B, Yim M. Surgical repair of nasal septal perforations: A systematic review and meta‐analysis. International Forum Of Allergy & Rhinology 2022, 12: 1104-1119. PMID: 34978162, DOI: 10.1002/alr.22965.Peer-Reviewed Original ResearchConceptsNasal septal perforationEndonasal approachSurgical managementSurgical repairSeptal perforationSuccess rateElectronic database searchCINAHL Plus databasesMedian MINORS scoreRandom-effects modelUse of graftsEnglish-language studiesNSP repairPooled proportionInterposition graftMethodological IndexStudy criteriaPrimary diagnosisSurgical approachMINORS scoreInclusion criteriaOutcome measuresUnilateral flapModerate heterogeneityBilateral flapsThe effects of stimulant dose and dosing strategy on treatment outcomes in attention-deficit/hyperactivity disorder in children and adolescents: a meta-analysis
Farhat LC, Flores JM, Behling E, Avila-Quintero VJ, Lombroso A, Cortese S, Polanczyk GV, Bloch MH. The effects of stimulant dose and dosing strategy on treatment outcomes in attention-deficit/hyperactivity disorder in children and adolescents: a meta-analysis. Molecular Psychiatry 2022, 27: 1562-1572. PMID: 35027679, DOI: 10.1038/s41380-021-01391-9.Peer-Reviewed Original ResearchConceptsFixed-dose trialAttention-deficit/hyperactivity disorderDose-limiting adverse eventsChildren/adolescentsAdverse eventsFlexible-dose trialTerms of efficacyClinical practiceHigh dosesFlexible dose designIntolerable adverse eventsHyperactivity disorderIncremental benefitLikelihood of discontinuationADHD symptomsLarge systematic reviewSchool-aged children/adolescentsFlexible titrationPotential long-term effectsSymptom controlTreatment discontinuationClinical outcomesStimulant dosesDaily dosesClinical guidelines
2021
Pharmacological and somatic treatment effects on suicide in adults: A systematic review and meta‐analysis
Wilkinson ST, Diaz D, Rupp ZW, Kidambi A, Ramirez KL, Flores JM, Avila‐Quintero V, Rhee TG, Olfson M, Bloch MH. Pharmacological and somatic treatment effects on suicide in adults: A systematic review and meta‐analysis. Depression And Anxiety 2021, 39: 100-112. PMID: 34762330, DOI: 10.1002/da.23222.Peer-Reviewed Original ResearchConceptsOdds of suicidePlacebo/Suicide riskPsychotic disordersBipolar disorderSystematic reviewSuicide deathsMeta-analyzed associationsNon-clozapine antipsychoticsMagnetic seizure therapySomatic interventionsVagus nerve stimulationNewcastle-Ottawa ScaleAntiepileptic mood stabilizersTranscranial magnetic stimulationCertain clinical contextsDirect current stimulationEffects of pharmacologicPublic health crisisSeizure therapyElectroconvulsive therapyNerve stimulationMood stabilizersStudy qualityProtective effectOpioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studies
De Aquino JP, Parida S, Avila-Quintero VJ, Flores J, Compton P, Hickey T, Gómez O, Sofuoglu M. Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studies. Drug And Alcohol Dependence 2021, 228: 109097. PMID: 34601272, PMCID: PMC8595687, DOI: 10.1016/j.drugalcdep.2021.109097.Peer-Reviewed Original ResearchConceptsOpioid agonist therapyOpioid use disorderExperimental pain studiesAbuse potentialRespiratory depressionAcute painPain studiesUse disordersSystematic reviewGreater abuse potentialHigh-potency opioidsMethadone-maintained personsSignificant pain reliefRespiratory depressant effectsHigh-potency compoundsOpioid naïveAgonist therapyOpioid dosesPain reliefAnalgesic effectSevere painDepressant effectAdditional dosesStudy qualityHealthy personsPalliative Care for Patients on Extracorporeal Membrane Oxygenation for COVID-19 Infection
Rao A, Zaaqoq AM, Kang IG, Vaughan EM, Flores J, Avila-Quintero VJ, Alnababteh MH, Kelemen AM, Groninger H. Palliative Care for Patients on Extracorporeal Membrane Oxygenation for COVID-19 Infection. American Journal Of Hospice And Palliative Medicine® 2021, 38: 854-860. PMID: 33685240, PMCID: PMC7944020, DOI: 10.1177/10499091211001009.Peer-Reviewed Original ResearchConceptsExtracorporeal membrane oxygenationPalliative care consultationCOVID-19 infectionPalliative care teamYears of ageCare consultationsPalliative careMembrane oxygenationIll patientsHigh morbidityCare teamNon-pain symptom managementOdds of deathPatients/familiesRates of anxietyAcademic medical centerSurrogate decision makersSymptom controlPatient characteristicsPain managementCase seriesClinical outcomesSymptom managementMedical complexityMedical CenterWho We Are Today: a National Survey of Diversity Among Psychiatry Program Directors
Lee PC, Flores JM, Adams A, Myint MT, Candelario AP, Bell IC, Avila-Quintero VJ, Cagande CC. Who We Are Today: a National Survey of Diversity Among Psychiatry Program Directors. Academic Psychiatry 2021, 45: 43-48. PMID: 33544376, DOI: 10.1007/s40596-021-01398-y.Peer-Reviewed Original ResearchConceptsPsychiatry program directorsFuture qualitative studiesHispanic/LatinxProgram director roleGlass ceilingMembership compositionInclusion CommitteeSoutheast AsiansQualitative studyCommunity settingsDisability/Leaky pipelineType of programJob rolesInternational medical graduatesFifty-sixCommittee's goalNational surveyStudy findingsRace/ethnicitySurveyDirectorsDirector roleMedical graduatesDemographic characteristicsRacial Implicit Associations in Psychiatric Diagnosis, Treatment, and Compliance Expectations
Londono Tobon A, Flores JM, Taylor JH, Johnson I, Landeros-Weisenberger A, Aboiralor O, Avila-Quintero VJ, Bloch MH. Racial Implicit Associations in Psychiatric Diagnosis, Treatment, and Compliance Expectations. Academic Psychiatry 2021, 45: 23-33. PMID: 33438155, PMCID: PMC7933096, DOI: 10.1007/s40596-020-01370-2.Peer-Reviewed Original Research
2020
Pharmacological treatment of pain among persons with opioid addiction: A systematic review and meta‐analysis with implications for drug development
De Aquino JP, Flores JM, Avila‐Quintero V, Compton P, Sofuoglu M. Pharmacological treatment of pain among persons with opioid addiction: A systematic review and meta‐analysis with implications for drug development. Addiction Biology 2020, 26: e12964. PMID: 32974993, DOI: 10.1111/adb.12964.Peer-Reviewed Original ResearchConceptsOpioid use disorderClinical trialsPresence of OUDSystematic reviewTreatment of OUDActive treatment groupNeurobiology of painDrug developmentSpontaneous painAntihyperalgesic effectOngoing painPharmacological managementAnalgesic effectClinical featuresCochrane DatabasePharmacological treatmentEligible studiesOpioid addictionPainTreatment groupsUse disordersAbuse liabilityNovel therapeuticsNonsignificant heterogeneityNeurobiological overlap
2019
Selective Serotonin Reuptake Inhibitor Use During Pregnancy—Associated With but Not Causative of Autism in Offspring
Flores JM, Avila-Quintero VJ, Bloch MH. Selective Serotonin Reuptake Inhibitor Use During Pregnancy—Associated With but Not Causative of Autism in Offspring. JAMA Psychiatry 2019, 76: 1225-1227. PMID: 31577332, DOI: 10.1001/jamapsychiatry.2019.2193.Commentaries, Editorials and Letters