2020
A Reduced Incretin Effect Mediated by the rs7903146 Variant in the TCF7L2 Gene Is an Early Marker of β-Cell Dysfunction in Obese Youth
Galderisi A, Tricò D, Pierpont B, Shabanova V, Samuels S, Man C, Galuppo B, Santoro N, Caprio S. A Reduced Incretin Effect Mediated by the rs7903146 Variant in the TCF7L2 Gene Is an Early Marker of β-Cell Dysfunction in Obese Youth. Diabetes Care 2020, 43: 2553-2563. PMID: 32788279, PMCID: PMC7510033, DOI: 10.2337/dc20-0445.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAllelesBiomarkersEarly DiagnosisFemaleGenotypeGlucose IntoleranceGlucose Tolerance TestHumansIncretinsInsulinInsulin ResistanceInsulin SecretionInsulin-Secreting CellsMalePancreatic DiseasesPediatric ObesityPolymorphism, Single NucleotideTranscription Factor 7-Like 2 ProteinYoung AdultConceptsOral glucose tolerance testIncretin effectRs7903146 variantObese youthVariant rs7903146Obese adolescentsHyperglycemic clampInsulin sensitivityInsulin secretionC-peptide secretion rateIsoglycemic intravenous glucose infusionGlucose-induced insulin secretionImpaired glucose toleranceMetabolic phenotypeGlucose tolerance testLower insulin secretionPlasma glucose peakIntravenous glucose infusionΒ-cell functionPlasma glucose concentrationΒ-cell dysfunctionT risk alleleTranscription factor 7Wild-type genotypeIncretin responseA Low ω-6 to ω-3 PUFA Ratio (n–6:n–3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth
Van Name MA, Savoye M, Chick JM, Galuppo BT, Feldstein AE, Pierpont B, Johnson C, Shabanova V, Ekong U, Valentino PL, Kim G, Caprio S, Santoro N. A Low ω-6 to ω-3 PUFA Ratio (n–6:n–3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth. Journal Of Nutrition 2020, 150: 2314-2321. PMID: 32652034, PMCID: PMC7467848, DOI: 10.1093/jn/nxaa183.Peer-Reviewed Original ResearchConceptsFatty liver diseasePNPLA3 rs738409 genotypeLiver diseaseAlanine aminotransferaseRs738409 genotypeInsulin sensitivityObese youthNonalcoholic fatty liver diseaseGenotype groupsWhole-body insulin sensitivityBody insulin sensitivityLinoleic acid metabolitesHepatic fat fractionMann-Whitney U testDiet imbalanceNormocaloric dietPrimary outcomeLDL cholesterolDietary interventionFatty liverUnblinded studyObese adolescentsPUFA dietMetabolic parametersStable weight
2018
A low visceral fat proportion, independent of total body fat mass, protects obese adolescent girls against fatty liver and glucose dysregulation: a longitudinal study
Umano GR, Shabanova V, Pierpont B, Mata M, Nouws J, Tricò D, Galderisi A, Santoro N, Caprio S. A low visceral fat proportion, independent of total body fat mass, protects obese adolescent girls against fatty liver and glucose dysregulation: a longitudinal study. International Journal Of Obesity 2018, 43: 673-682. PMID: 30337653, PMCID: PMC9354568, DOI: 10.1038/s41366-018-0227-6.Peer-Reviewed Original ResearchConceptsBody fat distributionHepatic fat contentGlucose metabolismVisceral fatInsulin resistanceObese adolescentsFat distributionWhole-body insulin sensitivity indexOral glucose tolerance testTotal body fat massSubcutaneous fatIntrahepatic fat contentImpaired glucose metabolismLow ratio groupGlucose tolerance testObese adolescent girlsSubjects/methodsWeBody fat massInsulin sensitivity indexHepatic fat accumulationMajor determinantGlucose dysregulationFatty liverTolerance testFat massTrajectories of changes in glucose tolerance in a multiethnic cohort of obese youths: an observational prospective analysis
Galderisi A, Giannini C, Weiss R, Kim G, Shabanova V, Santoro N, Pierpont B, Savoye M, Caprio S. Trajectories of changes in glucose tolerance in a multiethnic cohort of obese youths: an observational prospective analysis. The Lancet Child & Adolescent Health 2018, 2: 726-735. PMID: 30236381, PMCID: PMC6190831, DOI: 10.1016/s2352-4642(18)30235-9.Peer-Reviewed Original ResearchConceptsImpaired glucose toleranceNormal glucose toleranceOral disposition indexPersistent impaired glucose toleranceGlucose toleranceDisposition indexMultiethnic cohortObese adolescentsInsulin secretionObese youthBaseline normal glucose toleranceOral glucose tolerance testHigh-risk ethnic groupsStudy periodObservational prospective analysisPediatric obesity clinicAmerican Diabetes AssociationGlucose tolerance testAmerican Heart AssociationType 2 diabetesBody insulin sensitivityEthnic originΒ-cell responseΒ-cell functionBlack ethnic origin
2010
Central Role of Fatty Liver in the Pathogenesis of Insulin Resistance in Obese Adolescents
D'Adamo E, Cali AM, Weiss R, Santoro N, Pierpont B, Northrup V, Caprio S. Central Role of Fatty Liver in the Pathogenesis of Insulin Resistance in Obese Adolescents. Diabetes Care 2010, 33: 1817-1822. PMID: 20668154, PMCID: PMC2909068, DOI: 10.2337/dc10-0284.Peer-Reviewed Original ResearchConceptsObese adolescentsFatty liverHFF groupVisceral fatLower whole-body insulin sensitivity indexTwo-step hyperinsulinemic-euglycemic clampWhole-body insulin sensitivity indexOral glucose tolerance testBaseline fatty acidsHepatic glucose production rateLow-dose insulinAbdominal fat distributionGlucose disposal rateIntramyocellular lipid contentGlucose tolerance testBeta-cell functionHyperinsulinemic-euglycemic clampInsulin sensitivity indexBMI z-scoreHepatic fat contentInsulin-resistant statesMagnetic resonance imagingSuppression of EGPGlucose production rateInsulin resistanceEthnic differences in lipoprotein subclasses in obese adolescents: importance of liver and intraabdominal fat accretion
D'Adamo E, Northrup V, Weiss R, Santoro N, Pierpont B, Savoye M, O'Malley G, Caprio S. Ethnic differences in lipoprotein subclasses in obese adolescents: importance of liver and intraabdominal fat accretion. American Journal Of Clinical Nutrition 2010, 92: 500-508. PMID: 20573788, PMCID: PMC2921534, DOI: 10.3945/ajcn.2010.29270.Peer-Reviewed Original ResearchConceptsHepatic fat fractionObese adolescentsLarge HDLEthnic differencesFat accretionCardiometabolic risk factorsDeleterious metabolic effectsNormal glucose toleranceLipoprotein particle numberVisceral fat depositionLiver fat contentLarge VLDL particlesLarge HDL particlesImportance of liverMagnetic resonance imagingAfrican AmericansSuccessive tertilesMultivariate adjustmentGlucose toleranceLiver fatLower triglyceridesLipoprotein concentrationsRisk factorsLipoprotein subclassesMetabolic effects