2011
C. elegans meg‐1 and meg‐2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival
Kapelle WS, Reinke V. C. elegans meg‐1 and meg‐2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival. Genesis 2011, 49: 380-391. PMID: 21305687, DOI: 10.1002/dvg.20726.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsCell ProliferationCell SurvivalDisorders of Sex DevelopmentEmbryo, NonmammalianEpistasis, GeneticFemaleGene Expression Regulation, DevelopmentalGerm CellsLuminescent ProteinsMaleRNA InterferenceRNA-Binding ProteinsTime FactorsConceptsGerm cell proliferationMeg 1Germ cellsEmbryonic primordial germ cellsTargeted RNAi screenPrimordial germ cellsCell proliferationGerm cell survivalGerm lineageP granulesRNAi screenLarval stagesMEG 2Cell survivalFamily membersMultiple pathwaysGerm cell degenerationPhenotypeSterilityProliferationOptimal proliferationCellsCell degenerationEmbryogenesisLineages
2006
Promotion of oogenesis and embryogenesis in the C. elegans gonad by EFL-1/DPL-1 (E2F) does not require LIN-35 (pRB)
Chi W, Reinke V. Promotion of oogenesis and embryogenesis in the C. elegans gonad by EFL-1/DPL-1 (E2F) does not require LIN-35 (pRB). Development 2006, 133: 3147-3157. PMID: 16854972, DOI: 10.1242/dev.02490.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCaenorhabditis elegansCaenorhabditis elegans ProteinsE2F Transcription FactorsEmbryonic DevelopmentFertilityGene Expression Regulation, DevelopmentalGonadsOligonucleotide Array Sequence AnalysisOogenesisReceptors, LDLRepressor ProteinsRNA-Binding ProteinsTranscription FactorsTranscriptional ActivationConceptsEFL-1/DPLLin-35 mutantsLin-35Dpl-1Efl-1Target genesC. elegansTissue-specific transcriptional programsEctopic cell divisionE2F-binding sitesCell cycle componentsCaenorhabditis elegansTranscriptional programsEarly embryogenesisResponsive genesCell divisionCause defectsRegulatory regionsSomatic tissuesExpression profilingGene expressionReduced broodsOogenesisElegansFunction mutations