2021
Fibroblasts: Origins, definitions, and functions in health and disease
Plikus MV, Wang X, Sinha S, Forte E, Thompson SM, Herzog EL, Driskell RR, Rosenthal N, Biernaskie J, Horsley V. Fibroblasts: Origins, definitions, and functions in health and disease. Cell 2021, 184: 3852-3872. PMID: 34297930, PMCID: PMC8566693, DOI: 10.1016/j.cell.2021.06.024.Peer-Reviewed Original ResearchConceptsDiverse mesenchymal cellsComplex extracellular matrixCell fateCellular progenyTissue homeostasisCell cycleBiochemical cuesReversible plasticityExtracellular matrixPositional informationMesenchymal cellsSkeletal muscleTissue repairFibrotic disordersFibroblastsLineagesNicheProgenyHomeostasisPhenotypeOrgansFatePlasticityCellsFunction
2020
Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair
Shook BA, Wasko RR, Mano O, Rutenberg-Schoenberg M, Rudolph MC, Zirak B, Rivera-Gonzalez GC, López-Giráldez F, Zarini S, Rezza A, Clark DA, Rendl M, Rosenblum MD, Gerstein MB, Horsley V. Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair. Cell Stem Cell 2020, 26: 880-895.e6. PMID: 32302523, PMCID: PMC7853423, DOI: 10.1016/j.stem.2020.03.013.Peer-Reviewed Original ResearchConceptsSingle-cell RNA sequencingDermal adipocytesGenetic lineage tracingMammary gland biologyMature adipocytesGenetic mouse studiesAdipocyte-derived lipidsGenetic experimentsTissue homeostasisRNA sequencingLineage tracingECM-producing myofibroblastsDefective wound healingAdipocyte lipolysisMyofibroblast conversionAdipocyte functionEssential roleLipid releaseAdipocytesFatty acidsMacrophage inflammationInflammatory diseasesMultiple aspectsSkin repairMouse studies
2019
Lifting Each Other Up: Epidermal Stem Cells in Tissue Homeostasis
Horsley V. Lifting Each Other Up: Epidermal Stem Cells in Tissue Homeostasis. Developmental Cell 2019, 51: 296-298. PMID: 31689385, DOI: 10.1016/j.devcel.2019.10.013.Peer-Reviewed Original Research
2016
The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches
Shook B, Rivera Gonzalez G, Ebmeier S, Grisotti G, Zwick R, Horsley V. The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches. Annual Review Of Cell And Developmental Biology 2016, 32: 1-23. PMID: 27146311, PMCID: PMC5157158, DOI: 10.1146/annurev-cellbio-111315-125426.Peer-Reviewed Original ResearchConceptsStem cell nicheFunction of WATWhite adipose tissueTissue homeostasisCell nicheMetabolic regulationNovel roleMetabolic physiologyMajor regulatorMature adipocytesImmune tissuesVivo regulationEssential roleRole of adipocytesHomeostasisWhite adipocytesAdipocytesTissue regenerationRegulationEndocrine homeostasisRegenerationTissueNicheRegulatorRole
2014
Adipocytes in Skin Health and Disease
Rivera-Gonzalez G, Shook B, Horsley V. Adipocytes in Skin Health and Disease. Cold Spring Harbor Perspectives In Medicine 2014, 4: a015271. PMID: 24591537, PMCID: PMC3935392, DOI: 10.1101/cshperspect.a015271.Peer-Reviewed Original ResearchConceptsCutaneous biologyDermal adipocytesHair follicle growthTissue homeostasisDermal adipose tissueCellular basisRole of adipocytesAdipocytesHair cycleRegenerative capacityBiologyClinical manifestationsCutaneous diseaseReservoir of energyDermal compartmentAdipose tissueFollicle growthPotential roleSkin healthRecent studiesStructural supportWound healingDiseaseDynamic changesHomeostasis
2012
Split decisions: oesophageal progenitor cell behaviour
Horsley V. Split decisions: oesophageal progenitor cell behaviour. The EMBO Journal 2012, 31: 3653-3654. PMID: 22885597, PMCID: PMC3442277, DOI: 10.1038/emboj.2012.230.Peer-Reviewed Original Research
2011
Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling
Festa E, Fretz J, Berry R, Schmidt B, Rodeheffer M, Horowitz M, Horsley V. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling. Cell 2011, 146: 761-771. PMID: 21884937, PMCID: PMC3298746, DOI: 10.1016/j.cell.2011.07.019.Peer-Reviewed Original ResearchConceptsAdipocyte lineage cellsStem cell nicheStem cell activityLineage cellsCell nicheSkin stem cell nichesStem cell functionEpithelial stem cell nicheStem cell activationEpithelial stem cell functionSkin stem cellsTissue homeostasisNiche cellsFunctional analysisAdipogenic cellsSkin homeostasisMammalian skinTransplantation experimentsStem cellsPrecursor cellsHair cyclingCell functionAdipocyte cellsNicheFunctional tissue
2008
More than one way to skin . . .
Fuchs E, Horsley V. More than one way to skin . . . Genes & Development 2008, 22: 976-985. PMID: 18413712, PMCID: PMC2732395, DOI: 10.1101/gad.1645908.Peer-Reviewed Original ResearchConceptsStem cellsMultiple signaling networksNormal tissue homeostasisStem cell nicheStem cell populationResident stem cellsEpithelial-mesenchymal interactionsCell populationsCell fateSignaling networksSpecific lineagesTissue homeostasisCell nicheEpithelial stem cellsEpithelial lineageRecent cluesNormal homeostasisEpithelial tissuesLineagesWound repairHomeostasisCellsHair folliclesNicheFateNFATc1 Balances Quiescence and Proliferation of Skin Stem Cells
Horsley V, Aliprantis AO, Polak L, Glimcher LH, Fuchs E. NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells. Cell 2008, 132: 299-310. PMID: 18243104, PMCID: PMC2546702, DOI: 10.1016/j.cell.2007.11.047.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CD34BiomarkersCell NucleusCell ProliferationCells, CulturedCyclin-Dependent Kinase 4CyclosporineDown-RegulationEmbryo, MammalianGene DeletionGene ExpressionGene Expression Regulation, DevelopmentalGenes, ReporterHair FollicleImmunohistochemistryImmunosuppressive AgentsMiceMice, KnockoutMice, NudeMorphogenesisNFATC Transcription FactorsRetroviridaeRNA, MessengerSkinSkin TransplantationStem CellsTranscription FactorsTransgenesTransplantation, HomologousConceptsStem cellsHair growthCell quiescenceStem cell quiescenceExcessive hair growthFollicular growthNFATc1 signalingHair follicle stem cellsFollicle stem cellsGene ablationQuiescent adult stem cellsAdult stem cellsNFATc1Skin stem cellsFunctional roleCellsTissue homeostasisProliferationPatientsInjury