2021
Fibroblasts: Origins, definitions, and functions in health and disease
Plikus MV, Wang X, Sinha S, Forte E, Thompson SM, Herzog EL, Driskell RR, Rosenthal N, Biernaskie J, Horsley V. Fibroblasts: Origins, definitions, and functions in health and disease. Cell 2021, 184: 3852-3872. PMID: 34297930, PMCID: PMC8566693, DOI: 10.1016/j.cell.2021.06.024.Peer-Reviewed Original ResearchConceptsDiverse mesenchymal cellsComplex extracellular matrixCell fateCellular progenyTissue homeostasisCell cycleBiochemical cuesReversible plasticityExtracellular matrixPositional informationMesenchymal cellsSkeletal muscleTissue repairFibrotic disordersFibroblastsLineagesNicheProgenyHomeostasisPhenotypeOrgansFatePlasticityCellsFunction
2013
Notch signaling represses p63 expression in the developing surface ectoderm
Tadeu AM, Horsley V. Notch signaling represses p63 expression in the developing surface ectoderm. Development 2013, 140: 3777-3786. PMID: 23924630, PMCID: PMC3754476, DOI: 10.1242/dev.093948.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody PatterningCell DifferentiationEctodermEmbryonic Stem CellsEpidermal CellsEpidermisGene Expression Regulation, DevelopmentalHumansKeratin-14KeratinocytesMiceModels, BiologicalPhosphoproteinsReceptors, NotchRepressor ProteinsSignal TransductionStem CellsTrans-ActivatorsTranscription FactorsTumor Suppressor ProteinsConceptsHuman embryonic stem cellsProgenitor cellsMouse embryosKeratinocyte lineageProgenitor cell specificationEmbryonic stem cellsNegative regulatory roleKeratinocyte fateCell specificationEctodermal specificationInhibition of NotchTranscriptional changesMolecular controlNotch signalingRegulatory roleSurface ectodermP63 expressionStem cellsCoordinated sequenceLineagesMature epidermisEmbryosKeratin 14ExpressionCells
2011
Upward bound: follicular stem cell fate decisions
Horsley V. Upward bound: follicular stem cell fate decisions. The EMBO Journal 2011, 30: 2986-2987. PMID: 21811300, PMCID: PMC3160195, DOI: 10.1038/emboj.2011.231.Peer-Reviewed Original Research
2008
More than one way to skin . . .
Fuchs E, Horsley V. More than one way to skin . . . Genes & Development 2008, 22: 976-985. PMID: 18413712, PMCID: PMC2732395, DOI: 10.1101/gad.1645908.Peer-Reviewed Original ResearchConceptsStem cellsMultiple signaling networksNormal tissue homeostasisStem cell nicheStem cell populationResident stem cellsEpithelial-mesenchymal interactionsCell populationsCell fateSignaling networksSpecific lineagesTissue homeostasisCell nicheEpithelial stem cellsEpithelial lineageRecent cluesNormal homeostasisEpithelial tissuesLineagesWound repairHomeostasisCellsHair folliclesNicheFate
2007
Reprogramming somatic cells to their embryonic state
Horsley V, Fuchs E. Reprogramming somatic cells to their embryonic state. All Life 2007, 1: 89-93. PMID: 19404413, PMCID: PMC2639841, DOI: 10.2976/1.2757614.Peer-Reviewed Original ResearchES cellsSomatic cellsPluripotent fateStem cellsEmbryonic stem cellsES-like cellsHuman ES cellsCell Stem CellTranscription factorsEmbryonic cellsAdult bodyPluripotent potentialHuman diseasesTypes of cellsEmbryonic stateAbility of scientistsRegenerative medicineEmbryosCellsRegenerative therapyFatePluripotencyLineagesMechanismExpression
2006
Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland
Horsley V, O'Carroll D, Tooze R, Ohinata Y, Saitou M, Obukhanych T, Nussenzweig M, Tarakhovsky A, Fuchs E. Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland. Cell 2006, 126: 597-609. PMID: 16901790, PMCID: PMC2424190, DOI: 10.1016/j.cell.2006.06.048.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBromodeoxyuridineCell CountCell DifferentiationCell LineageCell MovementCell ProliferationCells, CulturedEpithelial CellsGene Expression Regulation, DevelopmentalHair FollicleHyperplasiaMiceMice, KnockoutMice, TransgenicMultipotent Stem CellsPositive Regulatory Domain I-Binding Factor 1Proto-Oncogene Proteins c-mycRepressor ProteinsSebaceous GlandsStem CellsTranscription FactorsConceptsMultipotent stem cellsCellular inputsGenetic lineage tracingStem cellsUnipotent progenitor cellsTranscriptional repressor Blimp1Stem cell activityElevated c-myc expressionLineage commitmentC-myc expressionBrdU-labeling experimentsLineage tracingProgenitor populationsLineagesBlimp1Progenitor cellsCell proliferationLabeling experimentsSebaceous glandsCellsCell culture studiesSG homeostasisHair folliclesHomeostasisGland