2021
Xenopus as a platform for discovery of genes relevant to human disease
Kostiuk V, Khokha MK. Xenopus as a platform for discovery of genes relevant to human disease. Current Topics In Developmental Biology 2021, 145: 277-312. PMID: 34074532, PMCID: PMC8734201, DOI: 10.1016/bs.ctdb.2021.03.005.Peer-Reviewed Original ResearchConceptsCandidate genesHuman diseasesDiscovery of genesScreen candidate genesMultiple candidate genesPatient genomic dataHuman genomePatient phenotypesDisease pathogenesisGenomic dataComplex phenotypesFate mapGene knockoutKnockdown strategyPatient mutationsBirth defectsXenopusFunctional studiesGenesPhenotypeCongenital birthAbnormal developmentCongenital heart diseaseCause of deathBetter diagnostic methods
2018
Genetic testing to modulate when to operate in thoracic aortic disease
Kostiuk V, Brownstein A, Ziganshin B, Elefteriades J. Genetic testing to modulate when to operate in thoracic aortic disease. Journal Of Visualized Surgery 2018, 4: 193-193. DOI: 10.21037/jovs.2018.07.14.Peer-Reviewed Original ResearchMolecular geneticsThoracic aortic aneurysmSurgical treatment optionsNon-syndromic thoracic aortic aneurysmsMolecular profilingSmooth muscle cell functionFamilial thoracic aortic aneurysmsMultiple genesSpecific genesMuscle cell functionTAA patientsTreatment optionsExtracellular matrixCell functionThoracic aortic diseaseGenesPositive family historyGeneticsProfilingTAA developmentAortic diseaseAortic aneurysmCurrent classificationDisease progressionFamily historyGenes Associated with Thoracic Aortic Aneurysm and Dissection: 2018 Update and Clinical Implications
Brownstein AJ, Kostiuk V, Ziganshin BA, Zafar MA, Kuivaniemi H, Body SC, Bale AE, Elefteriades JA. Genes Associated with Thoracic Aortic Aneurysm and Dissection: 2018 Update and Clinical Implications. Aorta 2018, 06: 013-020. PMID: 30079932, PMCID: PMC6136681, DOI: 10.1055/s-0038-1639612.Peer-Reviewed Original Research