2019
Hair follicle regeneration suppresses Ras-driven oncogenic growth
Pineda CM, Gonzalez DG, Matte-Martone C, Boucher J, Lathrop E, Gallini S, Fons NR, Xin T, Tai K, Marsh E, Nguyen DX, Suozzi KC, Beronja S, Greco V. Hair follicle regeneration suppresses Ras-driven oncogenic growth. Journal Of Cell Biology 2019, 218: 3212-3222. PMID: 31488583, PMCID: PMC6781447, DOI: 10.1083/jcb.201907178.Peer-Reviewed Original ResearchConceptsHair folliclesHras mutationsOncogenic growthHair follicle stem cellsSkin hair folliclesTumor developmentFollicle stem cellsHair follicle regenerationSkin epitheliumSecondary mutationsBenign outgrowthFolliclesStem cellsTissueCertain tissuesFollicle regenerationCellsContinuous tissueWild-type neighborsDistinct mechanismsDifferent outcomesMutationsEnhanced capacityInjury
2016
Hardwiring Stem Cell Communication through Tissue Structure
Xin T, Greco V, Myung P. Hardwiring Stem Cell Communication through Tissue Structure. Cell 2016, 164: 1212-1225. PMID: 26967287, PMCID: PMC4805424, DOI: 10.1016/j.cell.2016.02.041.Peer-Reviewed Original Research
2015
The Dynamic Duo: Niche/Stem Cell Interdependency
Mesa KR, Rompolas P, Greco V. The Dynamic Duo: Niche/Stem Cell Interdependency. Stem Cell Reports 2015, 4: 961-966. PMID: 26028534, PMCID: PMC4471832, DOI: 10.1016/j.stemcr.2015.05.001.Peer-Reviewed Original ResearchConceptsNormal tissue homeostasisStem cell behaviorStem cell interactionsTissue homeostasisCellular turnoverPathological settingsCell behaviorStem cellsMost tissuesFundamental processesDynamic duoCell interactionsModel systemNew cellsCell productionTissue regenerationCellsTissueLive miceOrganismsHomeostasisTremendous advancesImaging approachNovel imaging approachBasic understanding
2013
Spatial organization within a niche as a determinant of stem-cell fate
Rompolas P, Mesa KR, Greco V. Spatial organization within a niche as a determinant of stem-cell fate. Nature 2013, 502: 513-518. PMID: 24097351, PMCID: PMC3895444, DOI: 10.1038/nature12602.Peer-Reviewed Original ResearchConceptsStem cell fateHair follicle nicheStem cell lineagesStem cellsStem cell nicheHair follicle stem cellsStem cell compartmentFollicle stem cellsFate determinationGenetic lineagesDifferentiated fateAdult tissuesNiche locationsMammalian tissuesNicheHair regenerationLineagesSpatial organizationEpithelial cellsFateCellsHair growthRegenerationLive miceTissue
2001
Argosomes A Potential Vehicle for the Spread of Morphogens through Epithelia
Greco V, Hannus M, Eaton S. Argosomes A Potential Vehicle for the Spread of Morphogens through Epithelia. Cell 2001, 106: 633-645. PMID: 11551510, DOI: 10.1016/s0092-8674(01)00484-6.Peer-Reviewed Original ResearchConceptsWingless proteinFormation of morphogen gradientsImaginal disc epitheliumCell biological mechanismsSpreading of morphogensDisc epitheliumMorphogen gradientsArgosomesTissue patterningMorphogenWinglessMembrane fragmentsCell membraneProteinBiological mechanismsCellsAdjacent tissuesMembraneEndosomesBasolateral membranePotential vehicleTissueFragments