2015
Superantigens produced by catheter-associated Staphylococcus aureus elicit systemic inflammatory disease in the absence of bacteremia
Chung J, Greenwood-Quaintance K, Karau MJ, Tilahun A, Khaleghi SR, Chowdhary VR, David CS, Patel R, Rajagopalan G. Superantigens produced by catheter-associated Staphylococcus aureus elicit systemic inflammatory disease in the absence of bacteremia. Journal Of Leukocyte Biology 2015, 98: 271-281. PMID: 25979434, PMCID: PMC4501677, DOI: 10.1189/jlb.4a1214-577rr.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCatheter-Related InfectionsCatheters, IndwellingCD4-Positive T-LymphocytesEnterotoxinsGene DeletionHistocompatibility AntigensHumansKidneyLiverLungLymphocyte ActivationMiceMice, TransgenicReceptors, Antigen, T-Cell, alpha-betaSpleenStaphylococcal InfectionsStaphylococcus aureusSuperantigensConceptsS. aureusHLA-DR3 transgenic miceLong intravenous catheterSystemic immune activationSerum cytokine levelsSystemic inflammatory diseaseAbsence of bacteremiaMHC class II moleculesInvasive staphylococcal diseaseToxigenic S. aureusClinical S. aureus isolatesS. aureus isolatesClass II moleculesIsogenic S. aureusCytokine levelsHLA-DR3Immune activationInflammatory diseasesIntravenous cathetersStaphylococcal diseaseRole of SAgsDevice-associated infectionsT cellsClinical consequencesForeign body
2013
An unusual cause of diffuse pulmonary infiltrates
Krause ML, Boland JM, Maleszewski JJ, Gilbertson JR, Chowdhary VR. An unusual cause of diffuse pulmonary infiltrates. Arthritis Care & Research 2013, 65: 487-490. PMID: 23002027, DOI: 10.1002/acr.21860.Peer-Reviewed Original Research
2007
Characterization of haemorrhagic pulmonary capillaritis: another manifestation of Pristane-induced lupus
Chowdhary V, Grande J, Luthra H, David C. Characterization of haemorrhagic pulmonary capillaritis: another manifestation of Pristane-induced lupus. Rheumatology 2007, 46: 1405-1410. PMID: 17576695, DOI: 10.1093/rheumatology/kem117.Peer-Reviewed Original ResearchConceptsAnti-neutrophil cytoplasm antibodiesBronchoalveolar lavagePulmonary capillaritisAntinuclear antibodiesIL-10IL-6IL-4IL-2TNF-alphaIFN-gammaPhosphate-buffered saline injectionEvidence of vasculitisLupus-specific autoantibodiesPristane-induced lupusPristane-injected miceImmune complex depositionSingle intraperitoneal injectionDifferential cell countsPristane injectionAlveolar inflammationCytokine levelsCytoplasm antibodiesLupus lesionsNeutrophil infiltrationEndothelial injury
2005
HLA-DQ8 is a predisposing molecule for detergent enzyme subtilisin BPN′-induced hypersensitivity
Xue A, Chapoval SP, Finn ES, Chowdhary VR, Marietta EV, Gaffey TA, Pursifull AC, David CS. HLA-DQ8 is a predisposing molecule for detergent enzyme subtilisin BPN′-induced hypersensitivity. Clinical Immunology 2005, 117: 302-315. PMID: 16185928, DOI: 10.1016/j.clim.2005.08.003.Peer-Reviewed Original ResearchConceptsT cell responsesDQ8 miceCell responsesDR4 transgenic miceStrong susceptibility markerEosinophilic inflammatory reactionHLA-DQ8Intranasal instillationIgE productionInflammatory componentHLA-DQ6Tg miceInflammatory reactionSignificant IgG1Transgenic miceInduced hypersensitivityImmunogenic propertiesSusceptibility markersGenetic susceptibilityImmunodominant regionMiceVivo studiesAllergic propertiesHypersensitivityDetergent enzymes