2024
Is yearly interferon gamma release assay latent tuberculosis infection screening warranted among patients with rheumatological diseases on disease-modifying drugs in non-endemic settings?
Palacios C, Chowdhary V, Hao R, Danve A, Malinis M. Is yearly interferon gamma release assay latent tuberculosis infection screening warranted among patients with rheumatological diseases on disease-modifying drugs in non-endemic settings? PLOS ONE 2024, 19: e0306337. PMID: 38959249, PMCID: PMC11221665, DOI: 10.1371/journal.pone.0306337.Peer-Reviewed Original ResearchConceptsInterferon-gamma release assayDisease-modifying antirheumatic drugsInterferon-gamma release assay testLatent tuberculosis infectionNon-endemic settingsRheumatologic diseasesRisk factorsPositive interferon-gamma release assayLatent tuberculosis infection screeningLatent tuberculosis infection diagnosisPositive IGRA testMonths of rifampinLow-risk patientsRetrospective chart reviewTNF-alpha inhibitorsTB risk factorsTargeted LTBI screeningOutpatient rheumatology clinicDisease-modifying drugsIGRA testPatient demographicsAdult patientsChart reviewAntirheumatic drugsNon-endemic areas
2016
Incidence of systemic lupus erythematosus in a population-based cohort using revised 1997 American College of Rheumatology and the 2012 Systemic Lupus International Collaborating Clinics classification criteria
Ungprasert P, Sagar V, Crowson C, Amin S, Makol A, Ernste F, Osborn T, Moder K, Niewold T, Maradit-Kremers H, Ramsey-Goldman R, Chowdhary V. Incidence of systemic lupus erythematosus in a population-based cohort using revised 1997 American College of Rheumatology and the 2012 Systemic Lupus International Collaborating Clinics classification criteria. Lupus 2016, 26: 240-247. PMID: 27365370, PMCID: PMC5201452, DOI: 10.1177/0961203316657434.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusACR-97SLICC-12Lupus erythematosusSystemic Lupus International Collaborating Clinics classification criteriaSystemic Lupus International Collaborating Clinics (SLICC) groupClassification criteriaIncidence of lupusIncident SLE patientsRenal-limited diseaseSLICC-12 criteriaRochester Epidemiology ProjectACR classification criteriaPopulation-based cohortOlmsted CountyMedian durationSLE patientsAdjusted incidenceAmerican CollegeClinic groupHigh incidenceImmunologic criteriaNeurologic criteriaPatientsIncidence
2015
Autoimmune myelofibrosis with pancytopenia as a presenting manifestation of systemic lupus erythematosus responsive to mycophenolate mofetil
Ungprasert P, Chowdhary V, Davis M, Makol A. Autoimmune myelofibrosis with pancytopenia as a presenting manifestation of systemic lupus erythematosus responsive to mycophenolate mofetil. Lupus 2015, 25: 427-430. PMID: 26537421, DOI: 10.1177/0961203315615221.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusAutoimmune myelofibrosisLupus erythematosusBullous skin lesionsPresenting manifestationPeripheral destructionHematological abnormalitiesSkin lesionsMofetilErythematosusPancytopeniaMyelofibrosisManifestationsLeucopeniaThrombocytopeniaAnemiaGlucocorticoidsLesionsAbnormalitiesEpidemiology of Systemic Lupus Erythematosus and Cutaneous Lupus Erythematosus in a Predominantly White Population in the United States
Jarukitsopa S, Hoganson DD, Crowson CS, Sokumbi O, Davis MD, Michet CJ, Matteson EL, Maradit Kremers H, Chowdhary VR. Epidemiology of Systemic Lupus Erythematosus and Cutaneous Lupus Erythematosus in a Predominantly White Population in the United States. Arthritis Care & Research 2015, 67: 817-828. PMID: 25369985, PMCID: PMC4418944, DOI: 10.1002/acr.22502.Peer-Reviewed Original ResearchConceptsCutaneous lupus erythematosusSystemic lupus erythematosusSex-adjusted incidenceLupus erythematosusPrevalence of SLEClassic discoid lupus erythematosusBullous lupus erythematosusRochester Epidemiology ProjectSex-adjusted prevalenceDiscoid lupus erythematosusRheumatology classification criteriaWhite populationUS white populationCLE casesOlmsted CountyLupus panniculitisSLE casesMedical recordsErythematosusEpidemiologic studiesAmerican CollegePrevalenceIncidenceOlder adultsAgeSuperantigens produced by catheter-associated Staphylococcus aureus elicit systemic inflammatory disease in the absence of bacteremia
Chung J, Greenwood-Quaintance K, Karau MJ, Tilahun A, Khaleghi SR, Chowdhary VR, David CS, Patel R, Rajagopalan G. Superantigens produced by catheter-associated Staphylococcus aureus elicit systemic inflammatory disease in the absence of bacteremia. Journal Of Leukocyte Biology 2015, 98: 271-281. PMID: 25979434, PMCID: PMC4501677, DOI: 10.1189/jlb.4a1214-577rr.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCatheter-Related InfectionsCatheters, IndwellingCD4-Positive T-LymphocytesEnterotoxinsGene DeletionHistocompatibility AntigensHumansKidneyLiverLungLymphocyte ActivationMiceMice, TransgenicReceptors, Antigen, T-Cell, alpha-betaSpleenStaphylococcal InfectionsStaphylococcus aureusSuperantigensConceptsS. aureusHLA-DR3 transgenic miceLong intravenous catheterSystemic immune activationSerum cytokine levelsSystemic inflammatory diseaseAbsence of bacteremiaMHC class II moleculesInvasive staphylococcal diseaseToxigenic S. aureusClinical S. aureus isolatesS. aureus isolatesClass II moleculesIsogenic S. aureusCytokine levelsHLA-DR3Immune activationInflammatory diseasesIntravenous cathetersStaphylococcal diseaseRole of SAgsDevice-associated infectionsT cellsClinical consequencesForeign bodySynovial Infiltration in Human T Lymphotropic Virus Type I–Associated Adult T Cell Leukemia/Lymphoma
Koster MJ, McPhail ED, Chowdhary VR. Synovial Infiltration in Human T Lymphotropic Virus Type I–Associated Adult T Cell Leukemia/Lymphoma. Arthritis & Rheumatology 2015, 67: 945-945. PMID: 25604902, DOI: 10.1002/art.39038.Peer-Reviewed Original Research
2014
Pregnancy‐related issues in women with systemic lupus erythematosus
Singh AG, Chowdhary VR. Pregnancy‐related issues in women with systemic lupus erythematosus. International Journal Of Rheumatic Diseases 2014, 18: 172-181. PMID: 25545844, DOI: 10.1111/1756-185x.12524.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusActive diseaseLupus erythematosusPregnancy lossHigh-risk obstetric clinicRisk of flareAdverse pregnancy outcomesCongenital heart blockPregnancy-related issuesRecurrent pregnancy lossIntrauterine growth retardationPersonalized treatment strategiesTime of conceptionMaternal hypertensionActive nephritisAntiphospholipid antibodiesFetal outcomesNeonatal lupusPregnant patientsPreterm deliveryPregnancy outcomesPreterm birthHeart blockNeonatal mortalityAdverse outcomesIgG4‐related (neurologic) disease: diagnostic challenges, clinical clues and expanding spectrum
Flanagan EP, Chowdhary VR, McCarthy JT, Smyrk TC, Chari ST, Kumar N. IgG4‐related (neurologic) disease: diagnostic challenges, clinical clues and expanding spectrum. International Journal Of Rheumatic Diseases 2014, 18: 807-809. PMID: 25307728, DOI: 10.1111/1756-185x.12465.Peer-Reviewed Original Research
2013
CT angiographic imaging characteristics of thoracic idiopathic aortitis
Chowdhary VR, Crowson CS, Bhagra AS, Warrington KJ, Vrtiska TJ. CT angiographic imaging characteristics of thoracic idiopathic aortitis. Journal Of Cardiovascular Computed Tomography 2013, 7: 297-302. PMID: 24268116, DOI: 10.1016/j.jcct.2013.08.009.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAorta, ThoracicAortic Aneurysm, ThoracicAortitisAortographyAtherosclerosisDiabetes MellitusFemaleHumansHyperlipidemiasHypertensionMaleMiddle AgedPredictive Value of TestsPrevalenceRetrospective StudiesRisk FactorsSmokingTomography, X-Ray ComputedVascular CalcificationConceptsAtherosclerotic risk factorsControl group IIdiopathic aortitisControl group IIRisk factorsThoracic aortaGroup IIGroup IAortic diameterTraditional atherosclerotic risk factorsRetrospective case-control studyPrevalence of hypertensionCT angiographic findingsCase-control studyCT angiographic imagesLymphoplasmacytic inflammationAngiographic findingsCalcification scoreCurrent smokingDiffuse dilatationPathology databaseSecondary causesIA casesPatientsCase recordsDr. Ludvigsson, et al reply
LUDVIGSSON JF, RUBIO-TAPIA A, CHOWDHARY V, MURRAY JA, SIMARD JF. Dr. Ludvigsson, et al reply. The Journal Of Rheumatology 2013, 40: 1619-1619. PMID: 24137770, DOI: 10.3899/jrheum.130623.Peer-Reviewed Original ResearchAn unusual cause of diffuse pulmonary infiltrates
Krause ML, Boland JM, Maleszewski JJ, Gilbertson JR, Chowdhary VR. An unusual cause of diffuse pulmonary infiltrates. Arthritis Care & Research 2013, 65: 487-490. PMID: 23002027, DOI: 10.1002/acr.21860.Peer-Reviewed Original Research
2012
Chronic Exposure to Staphylococcal Superantigen Elicits a Systemic Inflammatory Disease Mimicking Lupus
Chowdhary VR, Tilahun AY, Clark CR, Grande JP, Rajagopalan G. Chronic Exposure to Staphylococcal Superantigen Elicits a Systemic Inflammatory Disease Mimicking Lupus. The Journal Of Immunology 2012, 189: 2054-2062. PMID: 22798666, PMCID: PMC3462343, DOI: 10.4049/jimmunol.1201097.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantibodiesAutoantigensAutoimmune DiseasesCD28 AntigensCD4-Positive T-LymphocytesEnzyme-Linked Immunosorbent AssayFlow CytometryFluorescent Antibody TechniqueHLA-DQ AntigensHumansInfusions, SubcutaneousLupus Erythematosus, SystemicMiceMice, TransgenicStaphylococcus aureusSuperantigensConceptsSystemic lupus erythematosusT cellsChronic exposureStaphylococcal enterotoxin BLupus erythematosusMouse MHC class II moleculesHLA-DQ8 transgenic miceMultisystem autoimmune inflammatory diseaseEnterotoxin BHLA-DQ8 miceAutoimmune inflammatory diseaseMHC class II moleculesTh1-type cytokinesMini-osmotic pumpsMononuclear cell infiltrationAnti-nuclear AbsClass II moleculesAbsence of diseaseChronic nasalIL-12Inflammatory infiltrateAutoimmune diseasesCell infiltrationInflammatory diseasesPathogenic roleIncreased Risk of Systemic Lupus Erythematosus in 29,000 Patients with Biopsy-verified Celiac Disease
Ludvigsson JF, Rubio-Tapia A, Chowdhary V, Murray JA, Simard JF. Increased Risk of Systemic Lupus Erythematosus in 29,000 Patients with Biopsy-verified Celiac Disease. The Journal Of Rheumatology 2012, 39: 1964-1970. PMID: 22859356, PMCID: PMC3463642, DOI: 10.3899/jrheum.120493.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusRisk of SLEHazard ratioCeliac diseaseLupus erythematosusAbsolute riskExcess riskGeneral populationPossible associationBiopsy-verified celiac diseaseIncident systemic lupus erythematosusSweden's 28 pathology departmentsSwedish Total Population RegisterDepartment of RheumatologySwedish Patient RegisterYears of followupPopulation-based studyTotal Population RegisterSimilar risk estimatesSLE diagnosisPatient RegisterCase seriesCox regressionCD diagnosisPathology department
2009
Noninfectious Ascending Aortitis: A Case Series of 64 Patients
Liang KP, Chowdhary VR, Michet CJ, Miller DV, Sundt TM, Connolly HM, Crowson CS, Matteson EL, Warrington KJ. Noninfectious Ascending Aortitis: A Case Series of 64 Patients. The Journal Of Rheumatology 2009, 36: 2290-2297. PMID: 19648309, DOI: 10.3899/jrheum.090081.Peer-Reviewed Original ResearchConceptsGiant cell arteritisAscending aortitisClinical presentationPreoperative erythrocyte sedimentation rateAortic aneurysm resectionMedian followup timePolymyalgia rheumatica symptomsRetrospective medical recordsErythrocyte sedimentation rateMajor aortic branchesAbsence of historyAdditional vascular abnormalitiesAneurysm resectionNoninfectious aortitisRheumatologic historyConstitutional symptomsCell arteritisImaging abnormalitiesInitial presentationSuch patientsCase seriesClinicopathologic featuresFollowup timeAbdominal aneurysmClinical entityCardiovascular risk factors and acute-phase response in idiopathic ascending aortitis: a case control study
Chowdhary VR, Crowson CS, Liang KP, Michet CJ, Miller DV, Warrington KJ, Matteson EL. Cardiovascular risk factors and acute-phase response in idiopathic ascending aortitis: a case control study. Arthritis Research & Therapy 2009, 11: r29. PMID: 19250534, PMCID: PMC2688264, DOI: 10.1186/ar2633.Peer-Reviewed Original ResearchConceptsErythrocyte sedimentation rateCase-control studyRisk factorsIdiopathic aortitisAortic aneurysmControl studyElevated acute phase reactantsC-reactive protein levelsCardiovascular risk factorsResultsThe mean ageAscending Aortic AneurysmAcute phase reactantsAcute phase responseActive smokingAscending aortitisInflammatory markersLymphoplasmacytic inflammationSystemic inflammationDiabetes mellitusMean ageControl subjectsRare conditionThoracic aortaFamily historyFemale gender
2008
Liver Involvement in Systemic Lupus Erythematosus: Case Review of 40 Patients
Chowdhary VR, Crowson CS, Poterucha JJ, Moder KG. Liver Involvement in Systemic Lupus Erythematosus: Case Review of 40 Patients. The Journal Of Rheumatology 2008, 35: 2159-2164. PMID: 18793002, DOI: 10.3899/jrheum.080336.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusEndstage liver diseaseLiver diseasePortal hypertensionLiver involvementViral hepatitisLupus erythematosusLiver disease-free survivalNonalcoholic fatty liver diseaseCoexistent liver diseaseSubclinical liver involvementDevelopment of cirrhosisLiver enzyme abnormalitiesAlanine aminotransferase levelsDisease-free survivalRetrospective chart reviewCohort of patientsFatty liver diseasePrimary biliary cirrhosisAlkaline phosphatase levelsClinical diagnostic groupsAutoimmune hepatitisCryptogenic cirrhosisHepatitis CAminotransferase levels
2007
Recurrent spells and bilateral internal carotid artery stenosis in a diabetic male: A test of patien‐ce(‐ts)
Chowdhary V, Kallmes DF, Fulgham J, Meyer F, Matteson EL. Recurrent spells and bilateral internal carotid artery stenosis in a diabetic male: A test of patien‐ce(‐ts). Arthritis & Rheumatism 2007, 57: 1098-1101. PMID: 17665478, DOI: 10.1002/art.22905.Peer-Reviewed Original Research
2002
Outcome in juvenile dermatomyositis.
Chowdhary V, Wakhlu A, Agarwal A, Misra R. Outcome in juvenile dermatomyositis. Indian Pediatrics 2002, 39: 931-5. PMID: 12428038.Peer-Reviewed Original ResearchConceptsJuvenile dermatomyositisComplete remissionMuscle involvementMuscle weaknessNeck muscle weaknessPharyngeal muscle involvementRespiratory muscle involvementTertiary care hospitalProximal muscle weaknessInterstitial lung diseaseGI bleedHeliotrope rashPartial remissionMedian durationCare hospitalMedian ageClinical featuresPyogenic infectionsLung diseaseRetrospective analysisPatientsCase recordsDermatomyositisRemissionComplications
2000
Sweet's syndrome and Pneumocystis carinii pneumonia: two sequelae of low‐dose cytosine arabinoside therapy in a patient with acute myeloid leukemia
Chowdhary V, Nityanand S, Prasad K, Pandey R, Dabadghao S. Sweet's syndrome and Pneumocystis carinii pneumonia: two sequelae of low‐dose cytosine arabinoside therapy in a patient with acute myeloid leukemia. European Journal Of Haematology 2000, 65: 72-73. PMID: 10914942, DOI: 10.1034/j.1600-0609.2000.9c177.x.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaPneumocystis carinii pneumoniaMyeloid leukemiaCarinii pneumoniaLow‐dose cytosine arabinoside therapyAcute febrile neutrophilic dermatosisAttainment of remissionFebrile neutrophilic dermatosisLow-dose cytosineNeutrophilic dermatosisSweet's syndromeImmunosuppressive potentialNeutrophil functionLow doseLow dosesLeukemiaPneumoniaSyndromeDirect effectRemissionSequelaePatientsDermatosesTherapyDose