2005
HLA-DQ8 is a predisposing molecule for detergent enzyme subtilisin BPN′-induced hypersensitivity
Xue A, Chapoval SP, Finn ES, Chowdhary VR, Marietta EV, Gaffey TA, Pursifull AC, David CS. HLA-DQ8 is a predisposing molecule for detergent enzyme subtilisin BPN′-induced hypersensitivity. Clinical Immunology 2005, 117: 302-315. PMID: 16185928, DOI: 10.1016/j.clim.2005.08.003.Peer-Reviewed Original ResearchConceptsT cell responsesDQ8 miceCell responsesDR4 transgenic miceStrong susceptibility markerEosinophilic inflammatory reactionHLA-DQ8Intranasal instillationIgE productionInflammatory componentHLA-DQ6Tg miceInflammatory reactionSignificant IgG1Transgenic miceInduced hypersensitivityImmunogenic propertiesSusceptibility markersGenetic susceptibilityImmunodominant regionMiceVivo studiesAllergic propertiesHypersensitivityDetergent enzymes
2002
HLA Class II Influences the Immune Response and Antibody Diversification to Ro60/Sjögren’s Syndrome-A: Heightened Antibody Responses and Epitope Spreading in Mice Expressing HLA-DR molecules
Paisansinsup T, Deshmukh US, Chowdhary VR, Luthra HS, Fu SM, David CS. HLA Class II Influences the Immune Response and Antibody Diversification to Ro60/Sjögren’s Syndrome-A: Heightened Antibody Responses and Epitope Spreading in Mice Expressing HLA-DR molecules. The Journal Of Immunology 2002, 168: 5876-5884. PMID: 12023392, DOI: 10.4049/jimmunol.168.11.5876.Peer-Reviewed Original ResearchConceptsHLA class II genesImmune responseCell epitopesB-cell epitopesDQ6 miceDQ8 miceSjögren's syndromeClass II genesDominant T cell epitopesMurine class II moleculesSystemic lupus erythematosusHLA class IISera of patientsB cell responsesDominant B-cell epitopesHLA-DR moleculesT cell epitopesClass II moleculesLupus erythematosusAntibody responseDR3 miceCell responsesHigh titersClass IISyndrome