2015
Obstructive Sleep Apnea: A New Preventive and Therapeutic Target for Stroke A New Kid on the Block
Mohsenin V. Obstructive Sleep Apnea: A New Preventive and Therapeutic Target for Stroke A New Kid on the Block. The American Journal Of Medicine 2015, 128: 811-816. PMID: 25731137, DOI: 10.1016/j.amjmed.2015.01.037.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesComorbidityDiabetes ComplicationsFemaleHumansMalePrevalenceRisk FactorsSleep Apnea, ObstructiveSmokingStrokeStroke RehabilitationUnited StatesConceptsObstructive sleep apneaSleep apneaRisk factorsPersistent neurologic impairmentStroke-related outcomesGood neurologic outcomePresence of hypertensionMajority of patientsRisk of strokeTraditional risk factorsCommon comorbid conditionsCause of deathNeurologic outcomeNeurologic recoverySecondary preventionComorbid conditionsNeurologic impairmentAtrial fibrillationDiagnostic workupEarly recognitionStroke rateApneaTherapeutic targetHealthcare providersStroke
2014
Increased Plasma YKL-40/Chitinase-3-Like-Protein-1 Is Associated with Endothelial Dysfunction in Obstructive Sleep Apnea
Jafari B, Elias JA, Mohsenin V. Increased Plasma YKL-40/Chitinase-3-Like-Protein-1 Is Associated with Endothelial Dysfunction in Obstructive Sleep Apnea. PLOS ONE 2014, 9: e98629. PMID: 24878721, PMCID: PMC4039537, DOI: 10.1371/journal.pone.0098629.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaFlow-mediated vasodilationVascular endothelial growth factorYKL-40/chitinaseApnea-hypopnea indexPlasma YKL-40YKL-40Endothelial dysfunctionVasodilatory capacitySleep apneaEndothelial-dependent vasodilatory capacityHypertensive OSANormotensive OSAApparent cardiovascular diseaseRisk of hypertensionProtein 1Events/hrEndothelial growth factorN-OSAVEGF receptor 1Oxygen desaturationSFlt-1Cardiovascular diseaseCommon disorderPositive correlation
2000
Sleep-related breathing disorders and cardiovascular disease
Roux F, D’Ambrosio C, Mohsenin V. Sleep-related breathing disorders and cardiovascular disease. The American Journal Of Medicine 2000, 108: 396-402. PMID: 10759096, DOI: 10.1016/s0002-9343(00)00302-8.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesCerebrovascular DisordersDeath, SuddenHeart FailureHumansHypertensionMyocardial InfarctionMyocardial IschemiaSleep Apnea SyndromesStrokeConceptsSleep-related breathing disordersBreathing disordersRisk factorsUpper airway resistance syndromeIndependent risk factorMajority of patientsMajor health problemPulmonary hypertensionSympathetic toneBaroreflex controlIntermittent hypoxiaExcessive daytimeSleep apneaCerebrovascular diseaseResistance syndromeEarly recognitionCardiovascular functionCardiovascular diseaseEpidemiologic studiesNeuropsychological dysfunctionHealth problemsMemory impairmentPoor work performanceDisordersHypertension