2023
Assessing Intrauterine Retention according to Microscopic Stillbirth Features: A Cluster Analysis Approach
Cersonsky T, Saade G, Silver R, Reddy U, Dudley D, Pinar H. Assessing Intrauterine Retention according to Microscopic Stillbirth Features: A Cluster Analysis Approach. Fetal And Pediatric Pathology 2023, 42: 860-869. PMID: 37571967, PMCID: PMC10843727, DOI: 10.1080/15513815.2023.2246571.Peer-Reviewed Original ResearchCervical Pessary for Prevention of Preterm Birth in Individuals With a Short Cervix
Hoffman M, Clifton R, Biggio J, Saade G, Ugwu L, Longo M, Bousleiman S, Clark K, Grobman W, Frey H, Chauhan S, Dugoff L, Manuck T, Chien E, Rouse D, Simhan H, Esplin M, Macones G, Bickus M, Facco F, Tita A, Grant J, Casey B, Harris S, Harper L, Dunn D, Longo S, Hendricks M, Lata-Arias K, Costantine M, Bartholomew A, Cline D, Harper S, Ward C, Gardner N, Brindle S, Weigand S, McKenna D, Snow E, Fennig K, Habli M, Lambers D, McClellan M, Metz T, Sowles A, Varner M, Hill K, Morby V, Meadows C, Allard D, Werner E, Rousseau J, Milano J, Pettker C, Leventhal J, Gyamfi-Bannerman C, Wapner R, Carmona V, Firman B, Vanneman A, Palomares K, Beche I, Skupski D, Chan-Akeley R, Salazar A, Pacheco L, McCoy L, Saad A, Jain S, Omere C, Clifford C, McDonnold M, Chien E, Dalton W, Polito L, Milluzi C, Kushner K, Maile A, Bell J, Hackney D, Ortiz F, Timlin S, Goodnight W, Manuck T, Beamon C, Nun H, Eichelberger K, Moore A, Hughes B, Ferrara J, Grobman W, Mallett G, Stein L, Miller E, Plunkett B, Kearns K, Palatnik A, Malone T, Parry S, Pizzi C, Craig J, Filipczak A, Thom E, Doherty L, Hubbard A, Erikson P, Pinto T, Marcharchand P, Reddy U, Miodovnik M, Archer S. Cervical Pessary for Prevention of Preterm Birth in Individuals With a Short Cervix. JAMA 2023, 330: 340-348. PMID: 37490086, PMCID: PMC10369212, DOI: 10.1001/jama.2023.10812.Peer-Reviewed Original ResearchConceptsCervical pessaryUsual carePreterm birthShort cervixVaginal progesteroneCervical lengthSingleton pregnanciesFetal deathPrimary outcomeInfant deathPrior spontaneous preterm birthTransvaginal ultrasound cervical lengthCervical pessary placementWeeks 0 daysSpontaneous preterm birthUltrasound cervical lengthWeeks 6 daysThird interim analysisNeonatal/infant mortalityPreterm deliverySingleton gestationsBaseline characteristicsUltrasound evidencePessary placementTransvaginal ultrasound
2017
Diagnostic Tests for Evaluation of Stillbirth
Page JM, Christiansen-Lindquist L, Thorsten V, Parker CB, Reddy UM, Dudley DJ, Saade GR, Coustan D, Hogue C, Conway D, Bukowski R, Pinar H, Heuser CC, Gibbins KJ, Goldenberg RL, Silver RM. Diagnostic Tests for Evaluation of Stillbirth. Obstetrics And Gynecology 2017, 129: 699-706. PMID: 28333795, DOI: 10.1097/aog.0000000000001937.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkCause of deathAntiphospholipid antibodiesPlacental pathologyDiagnostic testsEvaluation of stillbirthMedical record abstractionPopulation-based studyCollaborative research networksDeath classification systemResearch NetworkRecord abstractionSyphilis serologyClinical presentationToxicology screenAntibody screenClinical historyMaternal interviewsStillbirthSecondary analysisGenetic testingUseful testBiospecimen collectionStandardized evaluationMost participants
2016
Stillbirth, hypertensive disorders of pregnancy, and placental pathology
Gibbins KJ, Silver RM, Pinar H, Reddy UM, Parker CB, Thorsten V, Willinger M, Dudley DJ, Bukowski R, Saade GR, Koch MA, Conway D, Hogue CJ, Stoll BJ, Goldenberg RL. Stillbirth, hypertensive disorders of pregnancy, and placental pathology. Placenta 2016, 43: 61-68. PMID: 27324101, PMCID: PMC5893308, DOI: 10.1016/j.placenta.2016.04.020.Peer-Reviewed Original ResearchConceptsPlacental pathologyParenchymal infarctionLive birthsPreterm stillbirthSimilar clinical risk factorsStillbirth Collaborative Research NetworkPopulation-based cohort studyFetal vascular lesionsClinical risk factorsFeto-placental ratioGestational hypertensionRetroplacental hematomaHypertensive disordersCohort studyPlacental lesionsVascular lesionsAvascular villiFibrin depositionRisk factorsVascular thrombiStillbirthPregnancySecondary analysisInfarctionGH
2014
Association Between Stillbirth and Illicit Drug Use and Smoking During Pregnancy
Varner MW, Silver RM, Hogue C, Willinger M, Parker CB, Thorsten VR, Goldenberg RL, Saade GR, Dudley DJ, Coustan D, Stoll B, Bukowski R, Koch MA, Conway D, Pinar H, Reddy UM. Association Between Stillbirth and Illicit Drug Use and Smoking During Pregnancy. Obstetrics And Gynecology 2014, 123: 113-125. PMID: 24463671, PMCID: PMC3931517, DOI: 10.1097/aog.0000000000000052.Peer-Reviewed Original ResearchConceptsIllicit drug useCotinine assaysDrug useMaternal serum cotinine levelStillbirth Collaborative Research NetworkCannabis useSelf-reported smoking historyRisk of stillbirthLive-birth deliveriesSerum cotinine levelsCase-control studySecond-hand smokeUmbilical cord samplesIllicit drugsDose-response relationshipStillbirth deliverySmoking historyCotinine levelsMaternal serumSerum cotinineBirth deliveryCord homogenateSmoking useCord samplesStillbirth
2013
Bile acids in a multicenter, population-based case-control study of stillbirth
Silver RM, Parker CB, Goldenberg R, Reddy UM, Dudley DJ, Saade GR, Hogue CJ, Coustan D, Varner MW, Koch MA, Conway D, Bukowski R, Pinar H, Stoll B, Moore J, Willinger M. Bile acids in a multicenter, population-based case-control study of stillbirth. American Journal Of Obstetrics And Gynecology 2013, 210: 460.e1-460.e9. PMID: 24215860, PMCID: PMC4413928, DOI: 10.1016/j.ajog.2013.11.017.Peer-Reviewed Original ResearchConceptsPopulation-based case-control studyBile acid levelsCase-control studyLive birthsBile acidsStillbirth Collaborative Research NetworkAcid levelsBaseline risk factorsTerm live birthsPopulation-based studyCases of stillbirthTime of enrollmentProportion of womenMaternal serumClinical evidenceIntrahepatic cholestasisRisk factorsFetal anomaliesStillbirthElevated levelsWomenBirthSimilar proportionsCollaborative research networksResearch NetworkAntiphospholipid Antibodies in Stillbirth
Silver RM, Parker CB, Reddy UM, Goldenberg R, Coustan D, Dudley DJ, Saade GR, Stoll B, Koch MA, Conway D, Bukowski R, Hogue CJ, Pinar H, Moore J, Willinger M, Branch DW. Antiphospholipid Antibodies in Stillbirth. Obstetrics And Gynecology 2013, 122: 641-657. PMID: 23921873, PMCID: PMC5684877, DOI: 10.1097/aog.0b013e3182a1060e.Peer-Reviewed Original ResearchConceptsI antibodiesPopulation-based case-control studyLive-birth deliveriesOdds of stillbirthCase-control studyIgM anticardiolipinStillbirth deliveryAntiphospholipid antibodiesMaternal serumBirth deliveryLive birthsStillbirthElevated levelsAntibodiesIgGDeliveryAnticardiolipinMulticenterImmunoglobulinSerumAn Algorithm for the Estimation of Gestational Age at the Time of Fetal Death
Conway DL, Hansen NI, Dudley DJ, Parker CB, Reddy UM, Silver RM, Bukowski R, Pinar H, Stoll BJ, Varner MW, Saade GR, Hogue C, Willinger M, Coustan D, Koch MA, Goldenberg RL, Network E. An Algorithm for the Estimation of Gestational Age at the Time of Fetal Death. Paediatric And Perinatal Epidemiology 2013, 27: 145-157. PMID: 23374059, PMCID: PMC3564237, DOI: 10.1111/ppe.12037.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkFetal foot lengthFetal deathGestational agePopulation-based case-control studyFoot lengthWeeks of diagnosisCase-control studyGeographical catchment areasSingleton stillbirthsStillbirth casesPost-mortem dataStillbirthClinical practiceMore weeksDeathWeeksCollaborative research networksDiagnosisResearch NetworkShort intervalsLivebirthsWomen
2011
Stillbirth Collaborative Research Network: design, methods and recruitment experience
Parker CB, Hogue CJ, Koch MA, Willinger M, Reddy UM, Thorsten VR, Dudley DJ, Silver RM, Coustan D, Saade GR, Conway D, Varner MW, Stoll B, Pinar H, Bukowski R, Carpenter M, Goldenberg R, Network F. Stillbirth Collaborative Research Network: design, methods and recruitment experience. Paediatric And Perinatal Epidemiology 2011, 25: 425-435. PMID: 21819424, PMCID: PMC3665402, DOI: 10.1111/j.1365-3016.2011.01218.x.Peer-Reviewed Original ResearchConceptsStillbirth Collaborative Research NetworkPost-mortem examinationMaternal interviewsPlacental pathological examinationMedical record abstractionCase-control studyCase-control study participantsTime of deliveryHigher consent ratesGeographical catchment areasRecruitment experienceRecruitment hospitalChart abstractionProspective enrollmentPlacental pathologyRecord abstractionWeeks' gestationPathological examinationRisk factorsConsent ratesLivebirthsStillbirthClinical sitesStudy participantsAdditional surveillance
2010
A New System for Determining the Causes of Stillbirth
Dudley DJ, Goldenberg R, Conway D, Silver RM, Saade GR, Varner MW, Pinar H, Coustan D, Bukowski R, Stoll B, Koch MA, Parker CB, Reddy UM. A New System for Determining the Causes of Stillbirth. Obstetrics And Gynecology 2010, 116: 254-260. PMID: 20664383, PMCID: PMC3832680, DOI: 10.1097/aog.0b013e3181e7d975.Peer-Reviewed Original ResearchConceptsCause of deathStillbirth Collaborative Research NetworkFetal deathInitial causePlacental pathologic findingsPlacental pathology dataCauses of stillbirthMaternal medical conditionsMedical record abstractionStrict diagnostic criteriaHistologic chorioamnionitisObstetric complicationsPlacental infectionFetal infectionPlacental pathologyRecord abstractionGestational agePathologic findingsPathophysiologic sequencePrenatal careClinical evaluationHematologic conditionsMaternal interviewsPostmortem examinationMedical conditions
2007
Work-up of stillbirth: a review of the evidence
Silver RM, Varner MW, Reddy U, Goldenberg R, Pinar H, Conway D, Bukowski R, Carpenter M, Hogue C, Willinger M, Dudley D, Saade G, Stoll B. Work-up of stillbirth: a review of the evidence. American Journal Of Obstetrics And Gynecology 2007, 196: 433-444. PMID: 17466694, PMCID: PMC2699761, DOI: 10.1016/j.ajog.2006.11.041.Peer-Reviewed Original ResearchConceptsCauses of stillbirthStillbirth Collaborative Research NetworkFetal-maternal hemorrhageWeeks of gestationUtero fetal deathProportion of stillbirthsFetal deathIntrapartum carePrecise etiologyMedical conditionsChild healthStillbirthAcademic centersDiagnostic testsGenetic abnormalitiesNational InstituteCollaborative research networksResearch NetworkUnited StatesDiagnostic explanationCauseSystematic evaluationHemorrhageReviewGestation