2024
Stillbirth: we can do better
Silver R, Reddy U. Stillbirth: we can do better. American Journal Of Obstetrics And Gynecology 2024, 231: 152-165. PMID: 38789073, DOI: 10.1016/j.ajog.2024.05.042.Peer-Reviewed Original ResearchResource countriesNon-Hispanic blacksPrevention of stillbirthNon-Hispanic whitesOther Pacific IslanderRate of stillbirthLow-income countriesStillbirth rateStillbirthRisk factorsPacific IslandersGenetic etiologyPlacental assessmentEmotion managementRisk stratificationPreventionUnited StatesPregnancyRiskDisparitiesEpidemiologyCountriesU.S.WhitePostpartum readmission risk: a comparison between stillbirths and live births
Sweeney L, Reddy U, Campbell K, Xu X. Postpartum readmission risk: a comparison between stillbirths and live births. American Journal Of Obstetrics And Gynecology 2024, 231: 463.e1-463.e14. PMID: 38367754, DOI: 10.1016/j.ajog.2024.02.017.Peer-Reviewed Original ResearchRisk of readmissionMental health/substance use disordersPostpartum readmissionHigher risk of readmissionLive birthsRisk of postpartum readmissionSecondary outcomesDelivery characteristicsNationally representative estimatesComplex sampling designRisk factorsIncreased maternal morbidityHigher household incomeTime of readmissionWeeks of dischargeHypertensive disorders of pregnancyUse disorderHigh riskVenous thromboembolismChildbirth hospitalizationPrimary cesareanSingleton stillbirthsDisorders of pregnancyMultivariate regression modelMaternal morbidity
2023
Risk Factors, Trends, and Outcomes Associated With Postpartum Sepsis Readmissions
Liu L, Wen T, Reddy U, Mourad M, Goffman D, Nathan L, Sheen J, D'Alton M, Friedman A. Risk Factors, Trends, and Outcomes Associated With Postpartum Sepsis Readmissions. Obstetrics And Gynecology 2023, 143: 346-354. PMID: 37944152, DOI: 10.1097/aog.0000000000005437.Peer-Reviewed Original ResearchPostpartum readmissionDelivery hospitalizationsSepsis readmissionsJoinpoint Regression ProgramAdverse outcomesSepsis diagnosisSevere morbidityAssociated diagnosisRisk factorsNational Cancer Institute's Joinpoint Regression ProgramAverage annual percent changeRetrospective cohort studyClinical risk factorsNationwide Readmissions DatabaseMedian ZIP code incomeAdjusted odds ratioChronic medical conditionsIntra-amniotic infectionAnnual percent changeZip code incomeLogistic regression modelsChronic hypertensionMaternal sepsisPregestational diabetesCohort studyRisk Factors for Perinatal Transmission of Hepatitis C Virus
Prasad M, Saade G, Clifton R, Sandoval G, Hughes B, Reddy U, Bartholomew A, Salazar A, Chien E, Tita A, Thorp J, Metz T, Wapner R, Sabharwal V, Simhan H, Swamy G, Heyborne K, Sibai B, Grobman W, El-Sayed Y, Casey B, Parry S, Rathore M, Diaz-Velasco R, Puga A, Wiznia A, Kovacs A, Garry D, Macones G. Risk Factors for Perinatal Transmission of Hepatitis C Virus. Obstetrics And Gynecology 2023, 142: 449-456. PMID: 37590978, PMCID: PMC10437102, DOI: 10.1097/aog.0000000000005306.Peer-Reviewed Original ResearchConceptsPerinatal transmissionHCV infectionRisk factorsPrimary outcomeHuman Development Maternal-Fetal Medicine Units NetworkMaternal-Fetal Medicine Units NetworkHepatitis C virus infectionEunice Kennedy Shriver National InstituteC virus infectionPerinatal transmission rateWeeks of gestationHigh viral loadHepatitis C virusMonths of lifePositive test resultsAntepartum bleedingViremic participantsVaginal bleedingHCV RNAViremic individualsViral loadC virusObservational studyVirus infectionDemonstrable viremiaSearching and visualizing genetic associations of pregnancy traits by using GnuMoM2b
Yan Q, Guerrero R, Khan R, Surujnarine A, Wapner R, Hahn M, Raja A, Salleb-Aouissi A, Grobman W, Simhan H, Blue N, Silver R, Chung J, Reddy U, Radivojac P, Pe’er I, Haas D. Searching and visualizing genetic associations of pregnancy traits by using GnuMoM2b. Genetics 2023, 225: iyad151. PMID: 37602697, PMCID: PMC10691790, DOI: 10.1093/genetics/iyad151.Peer-Reviewed Original ResearchConceptsAdverse pregnancy outcomesNulliparous Pregnancy Outcomes StudyPregnancy Outcomes StudyMajor risk factorGenome-wide association studiesPregnancy outcomesGenetic associationMonitoring MothersRisk factorsOutcome studiesWomen's healthPhenome-wide association studySingle nucleotide polymorphismsAssociation studiesGenetic resultsPregnancyNucleotide polymorphismsRisk factors and perinatal outcomes for persistent placenta previa in nulliparas
Post R, Chang J, Ziogas A, Crosland B, Silver R, Haas D, Grobman W, Saade G, Reddy U, Simhan H, Chung J. Risk factors and perinatal outcomes for persistent placenta previa in nulliparas. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101136. PMID: 37598887, DOI: 10.1016/j.ajogmf.2023.101136.Peer-Reviewed Original ResearchPersistent placenta previaPlacenta previaMidtrimester ultrasoundRisk factorsPrevious pregnancyCesarean deliveryMaternal ageNulliparous Pregnancy Outcomes StudyLower neonatal birthweightOlder maternal agePrevious cesarean deliveryProspective cohort studyPregnancy Outcomes StudySignificant risk factorsMultivariate logistic regressionNulliparous individualsPrevious dilationNeonatal birthweightNeonatal outcomesPerinatal outcomesPreterm deliveryBaseline characteristicsCohort studyThird trimesterAntepartum admissionsResearching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design
Horwitz L, Thaweethai T, Brosnahan S, Cicek M, Fitzgerald M, Goldman J, Hess R, Hodder S, Jacoby V, Jordan M, Krishnan J, Laiyemo A, Metz T, Nichols L, Patzer R, Sekar A, Singer N, Stiles L, Taylor B, Ahmed S, Algren H, Anglin K, Aponte-Soto L, Ashktorab H, Bassett I, Bedi B, Bhadelia N, Bime C, Bind M, Black L, Blomkalns A, Brim H, Castro M, Chan J, Charney A, Chen B, Chen L, Chen P, Chestek D, Chibnik L, Chow D, Chu H, Clifton R, Collins S, Costantine M, Cribbs S, Deeks S, Dickinson J, Donohue S, Durstenfeld M, Emery I, Erlandson K, Facelli J, Farah-Abraham R, Finn A, Fischer M, Flaherman V, Fleurimont J, Fonseca V, Gallagher E, Gander J, Gennaro M, Gibson K, Go M, Goodman S, Granger J, Greenway F, Hafner J, Han J, Harkins M, Hauser K, Heath J, Hernandez C, Ho O, Hoffman M, Hoover S, Horowitz C, Hsu H, Hsue P, Hughes B, Jagannathan P, James J, John J, Jolley S, Judd S, Juskowich J, Kanjilal D, Karlson E, Katz S, Kelly J, Kelly S, Kim A, Kirwan J, Knox K, Kumar A, Lamendola-Essel M, Lanca M, Lee-Lannotti J, Lefebvre R, Levy B, Lin J, Logarbo B, Logue J, Longo M, Luciano C, Lutrick K, Malakooti S, Mallett G, Maranga G, Marathe J, Marconi V, Marshall G, Martin C, Martin J, May H, McComsey G, McDonald D, Mendez-Figueroa H, Miele L, Mittleman M, Mohandas S, Mouchati C, Mullington J, Nadkarni G, Nahin E, Neuman R, Newman L, Nguyen A, Nikolich J, Ofotokun I, Ogbogu P, Palatnik A, Palomares K, Parimon T, Parry S, Parthasarathy S, Patterson T, Pearman A, Peluso M, Pemu P, Pettker C, Plunkett B, Pogreba-Brown K, Poppas A, Porterfield J, Quigley J, Quinn D, Raissy H, Rebello C, Reddy U, Reece R, Reeder H, Rischard F, Rosas J, Rosen C, Rouphael N, Rouse D, Ruff A, Saint Jean C, Sandoval G, Santana J, Schlater S, Sciurba F, Selvaggi C, Seshadri S, Sesso H, Shah D, Shemesh E, Sherif Z, Shinnick D, Simhan H, Singh U, Sowles A, Subbian V, Sun J, Suthar M, Teunis L, Thorp J, Ticotsky A, Tita A, Tragus R, Tuttle K, Urdaneta A, Utz P, VanWagoner T, Vasey A, Vernon S, Vidal C, Walker T, Ward H, Warren D, Weeks R, Weiner S, Weyer J, Wheeler J, Whiteheart S, Wiley Z, Williams N, Wisnivesky J, Wood J, Yee L, Young N, Zisis S, Foulkes A. Researching COVID to Enhance Recovery (RECOVER) adult study protocol: Rationale, objectives, and design. PLOS ONE 2023, 18: e0286297. PMID: 37352211, PMCID: PMC10289397, DOI: 10.1371/journal.pone.0286297.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionRisk factorsClinical risk factorsPost-acute sequelaePrimary study outcomeProportional hazards regressionCommunity-based outreachMulti-site observational studyPASC symptomsQuarterly questionnairesRetrospective cohortVaccination statusOrgan dysfunctionAcute phaseLong COVIDHazards regressionEligible participantsTreatment optionsPrior infectionStudy protocolClinical trialsNew symptomsLongitudinal cohortLaboratory examinationsObservational studyMaternal Morbidity Risk Factors in Nulliparas
Merriam A, Metz T, Allshouse A, Silver R, Haas D, Grobman W, Simhan H, Wapner R, Wing D, Mercer B, Parry S, Reddy U, Investigators +. Maternal Morbidity Risk Factors in Nulliparas. American Journal Of Perinatology 2023, 41: e1878-e1884. PMID: 37150178, DOI: 10.1055/a-2088-2586.Peer-Reviewed Original ResearchVenous thromboembolic eventsSelf-identified black raceComposite maternal morbidityPrimary maternal outcomeSevere maternal morbidityMaternal morbidityChronic kidney diseaseBlack raceRisk factorsChronic hypertensionHypertensive disordersMaternal outcomesPregestational diabetesKidney diseaseMedical conditionsMulticenter prospective observational cohortPrepregnancy body mass indexPreexisting medical comorbiditiesPrior obstetric historyProspective observational cohortMorbidity risk factorsBody mass indexMultiple risk factorsDays of deliveryLog-binomial regression
2022
Copy number variants and fetal growth in stillbirths
Dalton S, Workalemahu T, Allshouse A, Page J, Reddy U, Saade G, Pinar H, Goldenberg R, Dudley D, Silver R. Copy number variants and fetal growth in stillbirths. American Journal Of Obstetrics And Gynecology 2022, 228: 579.e1-579.e11. PMID: 36356697, PMCID: PMC10149588, DOI: 10.1016/j.ajog.2022.11.1274.Peer-Reviewed Original ResearchConceptsAbnormal copy number variantsFetal growth abnormalitiesGestational ageOdds ratioStillbirth Collaborative Research NetworkGenetic abnormalitiesChromosomal microarrayGestational age outcomesGestational age infantsGrowth abnormalitiesClinical risk factorsCohort study designAdjusted odds ratioCopy number variantsUnknown clinical significancePathogenic copy number variantsPlacental insufficiencyAge infantsNumber variantsFetal growthMaternal ageRisk factorsClinical significanceHigh incidenceStillbirth
2021
Chronic hypertension, perinatal mortality and the impact of preterm delivery: a population‐based study
Grover S, Brandt J, Reddy U, Ananth C. Chronic hypertension, perinatal mortality and the impact of preterm delivery: a population‐based study. BJOG An International Journal Of Obstetrics & Gynaecology 2021, 129: 572-579. PMID: 34536318, PMCID: PMC9214277, DOI: 10.1111/1471-0528.16932.Peer-Reviewed Original ResearchConceptsPerinatal mortality rateChronic hypertensionEarly term deliveryPreterm deliveryPerinatal mortalityMortality rateTerm deliverySingleton birthsCausal mediation analysisMaternal chronic hypertensionElevated blood pressureModifiable risk factorsPopulation-based studyWeeks of gestationLate-term gestationCross-sectional analysisNormotensive pregnanciesPreterm birthBlood pressureTerm gestationPerinatal deathRisk factorsHypertensionMAIN OUTCOMEMortalityMaternal outcomes and risk factors for COVID-19 severity among pregnant women
Vouga M, Favre G, Martinez-Perez O, Pomar L, Acebal LF, Abascal-Saiz A, Hernandez MRV, Hcini N, Lambert V, Carles G, Sichitiu J, Salomon L, Stirnemann J, Ville Y, de Tejada BM, Goncé A, Hawkins-Villarreal A, Castillo K, Solsona EG, Trigo L, Cleary B, Geary M, Bartels H, Al-Kharouf F, Malone F, Higgins M, Keating N, Knowles S, Poncelet C, Ribeiro-do-Valle CC, Surita F, Dantas-Silva A, Borrelli C, Luz AG, Fuenzalida J, Carvajal J, Canales MG, Hernandez O, Grechukhina O, Ko AI, Reddy U, Figueiredo R, Moucho M, Pinto PV, De Luca C, De Santis M, de Campos DA, Martins I, Garabedian C, Subtil D, Bohrer B, Da Rocha Oppermann ML, Wender MCO, Schuler-Faccini L, Sanseverino MTV, Giugliani C, Friedrich L, Scherer MH, Mottet N, Ducarme G, Pelerin H, Moreau C, Breton B, Quibel T, Rozenberg P, Giannoni E, Granado C, Monod C, Mueller D, Hoesli I, Bassler D, Heldstab S, Kölble NO, Sentilhes L, Charvet M, Deprest J, Richter J, Van der Veeken L, Eggel-Hort B, Plantefeve G, Derouich M, Calvache AJN, Lopez-Giron MC, Burgos-Luna JM, Escobar-Vidarte MF, Hecher K, Tallarek AC, Hadar E, Haratz KK, Amikam U, Malinger G, Maymon R, Yogev Y, Schäffer L, Toussaint A, Rossier MC, De Sa RAM, Grawe C, Aebi-Popp K, Radan AP, Raio L, Surbek D, Böckenhoff P, Strizek B, Kaufmann M, Bloch A, Boulvain M, Johann S, Heldstab SA, Bernasconi MT, Grant G, Feki A, Brochut AM, Giral M, Sedille L, Papadia A, Brugger RC, Weber B, Fischer T, Kahlert C, Saines KN, Cambou M, Kanellos P, Chen X, Yin M, Haessig A, Ackermann S, Baud D, Panchaud A. Maternal outcomes and risk factors for COVID-19 severity among pregnant women. Scientific Reports 2021, 11: 13898. PMID: 34230507, PMCID: PMC8260739, DOI: 10.1038/s41598-021-92357-y.Peer-Reviewed Original ResearchConceptsSevere maternal outcomesPregnant womenRisk factorsMaternal outcomesPulmonary comorbiditiesHypertensive disordersNeonatal outcomesSevere complicationsHigh riskSevere acute respiratory syndrome coronavirus 2Severe coronavirus disease-19Severe COVID-19 diseaseAcute respiratory syndrome coronavirus 2Neonatal intensive care unitSARS-CoV-2 infectionRespiratory syndrome coronavirus 2Immediate neonatal outcomeIntensive care unitSyndrome coronavirus 2COVID-19 severityCase-control studyCoronavirus disease-19SARS-CoV-2COVID-19 diseaseMaternal disease
2020
Severe Maternal Morbidity During Delivery Hospitalization in a Large International Administrative Database, 2008-2013: A Retrospective Cohort
Lipkind H, Zuckerwise L, Turner E, Collins J, Campbell K, Reddy U, Illuzi J, Merriam A. Severe Maternal Morbidity During Delivery Hospitalization in a Large International Administrative Database, 2008-2013: A Retrospective Cohort. Obstetric Anesthesia Digest 2020, 40: 90-90. DOI: 10.1097/01.aoa.0000661440.79132.dd.Peer-Reviewed Original ResearchObstetric Care Consensus #10: Management of Stillbirth (Replaces Practice Bulletin Number 102, March 2009)
College of Obstetricians and Gynecologists A, with S, Metz TD, Berry RS, Fretts RC, Reddy UM, Turrentine MA. Obstetric Care Consensus #10: Management of Stillbirth (Replaces Practice Bulletin Number 102, March 2009). American Journal Of Obstetrics And Gynecology 2020, 222: b2-b20. PMID: 32004519, DOI: 10.1016/j.ajog.2020.01.017.Peer-Reviewed Original ResearchObstetric historyCommon adverse pregnancy outcomesNon-Hispanic black raceMaternal obstetric historyObstetric Care ConsensusAdverse pregnancy outcomesPast obstetric historyPrevalent risk factorsMale fetal sexAdvanced maternal ageTiming of deliveryHealth care providersPeer support groupsMental health professionalsChronic hypertensionMultiple gestationsPregnancy outcomesGestational ageBlack raceMaternal ageRisk factorsDefinite causeUnmarried statusHistologic examinationUmbilical cord161: Risk factors for Recurrent Stillbirth (SB): Results from the Stillbirth Collaborative Research Network (SCRN)
Whitham M, Gammon E, Chronister B, Urban A, Silver R, Reddy U, Dudley D. 161: Risk factors for Recurrent Stillbirth (SB): Results from the Stillbirth Collaborative Research Network (SCRN). American Journal Of Obstetrics And Gynecology 2020, 222: s116-s117. DOI: 10.1016/j.ajog.2019.11.177.Peer-Reviewed Original Research
2019
Severe maternal morbidity during delivery hospitalisation in a large international administrative database, 2008–2013: a retrospective cohort
Lipkind H, Zuckerwise L, Turner E, Collins J, Campbell K, Reddy U, Illuzi J, Merriam A. Severe maternal morbidity during delivery hospitalisation in a large international administrative database, 2008–2013: a retrospective cohort. BJOG An International Journal Of Obstetrics & Gynaecology 2019, 126: 1223-1230. PMID: 31100201, DOI: 10.1111/1471-0528.15818.Peer-Reviewed Original ResearchMeSH KeywordsAdultAustraliaCenters for Disease Control and Prevention, U.S.ComorbidityDatabases, FactualEnglandFemaleHospitalizationHumansMaternal AgeMaternal DeathMiddle AgedObstetric Labor ComplicationsPregnancyPregnancy ComplicationsPregnancy OutcomeRetrospective StudiesRisk FactorsUnited StatesYoung AdultConceptsSevere maternal morbidityMaternal morbidityDelivery hospitalisationRetrospective cohortRisk factorsSevere maternal morbidity ratesMaternal morbidity ratesAcute renal failureLife-threatening diagnosisAdvanced maternal ageLife-saving procedureLarge university hospitalChi-square testMorbidity variesPregnancy complicationsClinical characteristicsIntravascular coagulationRenal failureSevere morbidityMultivariable analysisMorbidity rateAdverse outcomesClinical differencesMaternal ageUniversity Hospital
2018
Nonmedically Indicated Induction in Morbidly Obese Women is Not Associated With an Increased Risk of Cesarean Delivery
Kawakita T, Iqbal S, Huang C, Reddy U. Nonmedically Indicated Induction in Morbidly Obese Women is Not Associated With an Increased Risk of Cesarean Delivery. Obstetric Anesthesia Digest 2018, 38: 125-126. DOI: 10.1097/01.aoa.0000542343.43890.b0.Peer-Reviewed Original ResearchInduction of laborMorbidly obese womenCesarean deliveryObese womenExpectant managementClass III obesityRetrospective cohort studyNormal-weight womenIndicated inductionMaternal comorbiditiesMorbid obesityNeonatal outcomesCohort studySecondary outcomesWeeks' gestationRisk factorsHigh prevalenceClass IIObesityWomenComorbiditiesInductionOutcomesDeliveryRisk
2017
Altered fetal growth, placental abnormalities, and stillbirth
Bukowski R, Hansen NI, Pinar H, Willinger M, Reddy UM, Parker CB, Silver RM, Dudley DJ, Stoll BJ, Saade GR, Koch MA, Hogue C, Varner MW, Conway DL, Coustan D, Goldenberg RL, . Altered fetal growth, placental abnormalities, and stillbirth. PLOS ONE 2017, 12: e0182874. PMID: 28820889, PMCID: PMC5562325, DOI: 10.1371/journal.pone.0182874.Peer-Reviewed Original ResearchConceptsFetal growth abnormalitiesAltered fetal growthFetal growthLive birthsPlacental abnormalitiesPlacental findingsGrowth abnormalitiesImpaired placental functionSingleton live birthsCase-control studyCause of deathPatterns of associationSingleton stillbirthsPlacental examinationTerm stillbirthGestational ageRisk factorsPerinatal pathologistsPlacental functionClinical careStillbirthAbnormalitiesStandardized protocolBirthDeath
2016
Stillbirth, hypertensive disorders of pregnancy, and placental pathology
Gibbins KJ, Silver RM, Pinar H, Reddy UM, Parker CB, Thorsten V, Willinger M, Dudley DJ, Bukowski R, Saade GR, Koch MA, Conway D, Hogue CJ, Stoll BJ, Goldenberg RL. Stillbirth, hypertensive disorders of pregnancy, and placental pathology. Placenta 2016, 43: 61-68. PMID: 27324101, PMCID: PMC5893308, DOI: 10.1016/j.placenta.2016.04.020.Peer-Reviewed Original ResearchConceptsPlacental pathologyParenchymal infarctionLive birthsPreterm stillbirthSimilar clinical risk factorsStillbirth Collaborative Research NetworkPopulation-based cohort studyFetal vascular lesionsClinical risk factorsFeto-placental ratioGestational hypertensionRetroplacental hematomaHypertensive disordersCohort studyPlacental lesionsVascular lesionsAvascular villiFibrin depositionRisk factorsVascular thrombiStillbirthPregnancySecondary analysisInfarctionGH
2013
Bile acids in a multicenter, population-based case-control study of stillbirth
Silver RM, Parker CB, Goldenberg R, Reddy UM, Dudley DJ, Saade GR, Hogue CJ, Coustan D, Varner MW, Koch MA, Conway D, Bukowski R, Pinar H, Stoll B, Moore J, Willinger M. Bile acids in a multicenter, population-based case-control study of stillbirth. American Journal Of Obstetrics And Gynecology 2013, 210: 460.e1-460.e9. PMID: 24215860, PMCID: PMC4413928, DOI: 10.1016/j.ajog.2013.11.017.Peer-Reviewed Original ResearchConceptsPopulation-based case-control studyBile acid levelsCase-control studyLive birthsBile acidsStillbirth Collaborative Research NetworkAcid levelsBaseline risk factorsTerm live birthsPopulation-based studyCases of stillbirthTime of enrollmentProportion of womenMaternal serumClinical evidenceIntrahepatic cholestasisRisk factorsFetal anomaliesStillbirthElevated levelsWomenBirthSimilar proportionsCollaborative research networksResearch NetworkStillbirth: Knowledge and Practice among U.S. Obstetrician-Gynecologists
Farrow V, McClure E, Reddy U, Fretts R, Schulkin J, Goldenberg R. Stillbirth: Knowledge and Practice among U.S. Obstetrician-Gynecologists. American Journal Of Perinatology 2013, 30: 813-820. PMID: 23329563, DOI: 10.1055/s-0032-1333407.Peer-Reviewed Original ResearchConceptsRisk factorsStandardized order sheetsU.S. Obstetrician-GynecologistsCauses of stillbirthElevated α-fetoproteinAdvanced maternal ageCause of deathIllicit drug useOBGYN departmentsStillbirth causesStillbirth evaluationStillbirth managementPercent of respondentsMultiple gestationsCigarette smokingMaternal ageObstetrician-GynecologistsAmerican CollegeStillbirthDrug useOrder sheetEffective interventionsMost hospitalsΑ-fetoproteinGrand rounds