2023
Comparing population-based fetal growth standards in a US cohort
Gleason J, Reddy U, Chen Z, Grobman W, Wapner R, Steller J, Simhan H, Scifres C, Blue N, Parry S, Grantz K. Comparing population-based fetal growth standards in a US cohort. American Journal Of Obstetrics And Gynecology 2023, 231: 338.e1-338.e18. PMID: 38151220, PMCID: PMC11196385, DOI: 10.1016/j.ajog.2023.12.034.Peer-Reviewed Original ResearchComposite perinatal morbidityFetal growth standardsPerinatal morbidityNeonatal morbidityWorld Health OrganizationGrowth standardsEunice Kennedy Shriver National InstituteNulliparous Pregnancy Outcomes StudyHighest AUCComposite neonatal morbiditySubsequent neonatal morbidityU.S. clinical centersFetal growth restrictionRisk of morbidityRace/Management of pregnancyPregnancy Outcomes StudyAntenatal monitoringNulliparous womenFetal weightFirst trimesterVisit 2Visit 3US cohortClinical centersAssociation between Sleep Disordered Breathing and Neonatal Outcomes in Nulliparous Individuals
Delgado A, Kendle A, Randis T, Donda K, Salemi J, Facco F, Parker C, Reddy U, Silver R, Basner R, Chung J, Schubert F, Pien G, Redline S, Parry S, Grobman W, Zee P, Louis J. Association between Sleep Disordered Breathing and Neonatal Outcomes in Nulliparous Individuals. American Journal Of Perinatology 2023, 41: e2418-e2426. PMID: 37380034, DOI: 10.1055/a-2115-0147.Peer-Reviewed Original ResearchSleep-disordered breathingAdverse neonatal outcomesNeonatal outcomesPrimary outcomeRisk ratioApnea-hypopnea indexRespiratory distress syndromeBody mass indexEvents/hConfidence intervalsSleep Disordered BreathingLog-binomial regressionNulliparous individualsHome sleep studiesChronic hypertensionNeonatal morbidityNew onsetPregestational diabetesComposite outcomeRespiratory supportTransient tachypneaDistress syndromeGestational ageMass indexMaternal riskPROMPT: Prospective Meta-analysis for Pessary Trials Study Protocol
Thom E, Saade G, Askie L, Ugwu L, Mol B, Vayssiere C, Norman J, Pajkrt E, Clifton R, Biggio J, Arnaud C, Berghella V, Canino M, Carreras E, Dugoff L, Hoffman M, Pacagnella R, Reddy U, Saccone G, van 't Hooft J, Dang V, Collaboration F. PROMPT: Prospective Meta-analysis for Pessary Trials Study Protocol. American Journal Of Perinatology 2023, 41: e2230-e2237. PMID: 37429323, PMCID: PMC10776795, DOI: 10.1055/s-0043-1771018.Peer-Reviewed Original ResearchShort cervical lengthPreterm birthIndividual patient dataShort cervixRandomized trialsPessary trialCervical lengthTwin gestationsSubsequent spontaneous preterm birthLong-term neurological disabilityOngoing randomized trialsSpontaneous preterm birthTrial study protocolWeeks of gestationProspective Meta-AnalysisSignificant health issueCervical supportNeonatal morbidityPreterm deliverySingleton gestationsSecondary outcomesFetal deathNeurological disabilityPrimary outcomeWeeks' gestationAssociation of maternal body mass index with success and outcomes of attempted operative vaginal delivery
Grasch J, Venkatesh K, Grobman W, Silver R, Saade G, Mercer B, Yee L, Scifres C, Parry S, Simhan H, Reddy U, Frey H. Association of maternal body mass index with success and outcomes of attempted operative vaginal delivery. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101081. PMID: 37422004, DOI: 10.1016/j.ajogmf.2023.101081.Peer-Reviewed Original ResearchConceptsMaternal body mass indexBody mass indexOperative vaginal deliveryVaginal delivery attemptComposite maternal morbidityComposite neonatal morbidityVaginal deliveryMass indexNeonatal morbidityCesarean deliveryMaternal morbidityAdverse outcomesSecond-stage cesarean deliveryBody mass index groupsBody mass index categoriesNulliparous Pregnancy Outcomes StudyNonanomalous singleton pregnanciesNeonatal adverse outcomesMultivariable logistic regressionPregnancy Outcomes StudyNulliparous individualsDose-dependent mannerSecondary outcomesSingleton pregnanciesPrimary outcomeFetal growth restriction and small for gestational age as predictors of neonatal morbidity: which growth nomogram to use?
Leon-Martinez D, Lundsberg L, Culhane J, Zhang J, Son M, Reddy U. Fetal growth restriction and small for gestational age as predictors of neonatal morbidity: which growth nomogram to use? American Journal Of Obstetrics And Gynecology 2023, 229: 678.e1-678.e16. PMID: 37348779, DOI: 10.1016/j.ajog.2023.06.035.Peer-Reviewed Original ResearchConceptsNeonatal composite outcomeComposite outcomeFetal growth restrictionGestational ageFetal weightWeeks of gestationPositive likelihood ratioGrowth restrictionNonanomalous singleton pregnanciesPoor neonatal outcomeRetrospective cohort studySingle academic centerWeeks of deliveryDays of deliveryFetal growth referencesElectronic medical recordsProportion of fetusesLikelihood ratioNeonatal morbidityNeonatal outcomesPerinatal outcomesCohort studySingleton pregnanciesNeonatal dataMedical recordsOutcomes of induction vs prelabor cesarean delivery at <33 weeks for hypertensive disorders of pregnancy
Bushman E, Grobman W, Bailit J, Reddy U, Wapner R, Varner M, Thorp J, Caritis S, Prasad M, Saade G, Sorokin Y, Rouse D, Blackwell S, Tolosa J, Network E. Outcomes of induction vs prelabor cesarean delivery at <33 weeks for hypertensive disorders of pregnancy. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101032. PMID: 37244639, PMCID: PMC10521213, DOI: 10.1016/j.ajogmf.2023.101032.Peer-Reviewed Original ResearchConceptsPrelabor cesarean deliveryHypertensive disordersInduction of laborCesarean deliveryLabor inductionNeonatal morbidityInduction groupMedian durationVaginal deliveryWeeks' gestationSecondary analysisAdverse composite outcomeComposite maternal morbidityOutcome of inductionPreterm hypertensive disordersHalf of patientsCesarean delivery groupLength of inductionOptimal delivery approachMaternal morbidityComposite outcomeFetal malpresentationMultiple gestationsPreterm birthSecondary outcomesShort-term neonatal outcomes of pregnancies complicated by maternal obesity
Dinsmoor M, Ugwu L, Bailit J, Reddy U, Wapner R, Varner M, Thorp J, Caritis S, Prasad M, Tita A, Saade G, Sorokin Y, Rouse D, Blackwell S, Tolosa J, Network E. Short-term neonatal outcomes of pregnancies complicated by maternal obesity. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 100874. PMID: 36690180, PMCID: PMC10065915, DOI: 10.1016/j.ajogmf.2023.100874.Peer-Reviewed Original ResearchConceptsComposite neonatal morbidityNeonatal outcomesBody mass indexWeeks of gestationMaternal obesityNeonatal morbidityMorbid obesityMass indexReference groupIntraventricular hemorrhage grade 3Short-term neonatal outcomesCohort of deliveriesComposite neonatal outcomeSuper morbid obesityHypoxic-ischemic encephalopathyPrevious cesarean deliveryRespiratory distress syndromeChronic hypertensionPreterm deliveryBaseline characteristicsCesarean deliveryComposite outcomeMaternal heightMaternal preeclampsiaObese patients
2021
Outcomes in Twins Compared With Singletons Subsequent to Preterm Prelabor Rupture of Membranes
Bartal M, Ugwu LG, Grobman WA, Bailit JL, Reddy UM, Wapner RJ, Varner MW, Thorp JM, Caritis SN, Prasad M, Tita ATN, Saade GR, Rouse DJ. Outcomes in Twins Compared With Singletons Subsequent to Preterm Prelabor Rupture of Membranes. Obstetrics And Gynecology 2021, 138: 725-731. PMID: 34619719, PMCID: PMC8542618, DOI: 10.1097/aog.0000000000004561.Peer-Reviewed Original ResearchMeSH KeywordsAdultChorioamnionitisCohort StudiesEndometritisEnterocolitis, NecrotizingFemaleFetal Membranes, Premature RuptureGestational AgeHumansInfant, NewbornInfant, PrematureOutcome Assessment, Health CarePerinatal MortalityPregnancyPregnancy OutcomePregnancy, TwinPremature BirthSepsisVenous ThromboembolismWound InfectionYoung AdultConceptsComposite maternal morbidityPreterm prelabor ruptureWeeks of gestationNeonatal morbidityPreterm PROMSingleton gestationsMaternal morbidityPrelabor ruptureTwin gestationsOdds ratioComposite major neonatal morbidityComposite neonatal morbidityMajor neonatal morbidityMedian gestational ageMedian latency periodMajor fetal anomaliesAdjusted odds ratioCoprimary outcomesObstetric cohortNeonatal outcomesTwin neonatesGestational agePotential confoundersFetal anomaliesMorbidity
2019
Neonatal Outcomes of Elective Early-term Births After Demonstrated Fetal Lung Maturity
Tita A, Jablonski K, Bailit J, Grobman W, Wapner R, Reddy U, Varner M, Thorp J, Leveno K, Caritis S, Iams J, Saade G, Sorokin Y, Rouse D, Blackwell S, Tolosa J. Neonatal Outcomes of Elective Early-term Births After Demonstrated Fetal Lung Maturity. Obstetric Anesthesia Digest 2019, 39: 93-93. DOI: 10.1097/01.aoa.0000557681.76214.2f.Peer-Reviewed Original ResearchFetal lung maturity testingLung maturity testingEarly term birthEarly-term neonatesFetal lung maturityNeonatal outcomesMaturity testingLung maturityAdverse neonatal outcomesFull-term birthFull-term neonatesNeonatal morbidityRespiratory outcomesEarly deliveryAbsence of indicationsNeonatesBirthOutcomesRiskPretermMorbidityTesting
2018
Reassessing the Duration of the Second Stage of Labor in Relation to Maternal and Neonatal Morbidity
Grantz K, Sundaram R, Ma L, Hinkle S, Berghella V, Hoffman M, Reddy U. Reassessing the Duration of the Second Stage of Labor in Relation to Maternal and Neonatal Morbidity. Obstetric Anesthesia Digest 2018, 38: 71. DOI: 10.1097/01.aoa.0000532263.77010.0d.Peer-Reviewed Original ResearchNeonatal morbidityInitial cesarean sectionMaternal febrile morbiditySecond-stage arrestMaternal-fetal medicineFebrile morbidityEpidural analgesiaCesarean sectionMultiparous womenNulliparous womenPostpartum hemorrhageVaginal birthAmerican CollegeMorbidityMortalityWomenPresent studyBirthHoursAnalgesiaEpiduralHemorrhagePatientsGynecologistsObstetriciansReassessing the Duration of the Second Stage of Labor in Relation to Maternal and Neonatal Morbidity
Grantz KL, Sundaram R, Ma L, Hinkle S, Berghella V, Hoffman MK, Reddy UM. Reassessing the Duration of the Second Stage of Labor in Relation to Maternal and Neonatal Morbidity. Obstetrics And Gynecology 2018, 131: 345-353. PMID: 29324600, PMCID: PMC5785437, DOI: 10.1097/aog.0000000000002431.Peer-Reviewed Original ResearchConceptsSpontaneous vaginal birthSecond stage durationVaginal birthNulliparous womenNeonatal complicationsNeonatal morbidityCesarean deliveryFetal heart rate tracingsFirst half hourPrior cesarean deliverySpontaneous vaginal deliveryWeeks of gestationHeart rate tracingsVertex birthsRetrospective cohortMultiparous womenSerious complicationsSerious morbidityVaginal deliveryMorbidityHalf hourLikelihood of birthComplicationsWomenBirth
2016
Antenatal Betamethasone for Women at Risk for Late Preterm Delivery
Gyamfi-Bannerman C, Thom E, Blackwell S, Tita A, Reddy U, Saade G, Rouse D, McKenna D, Clark E, Thorp J, Chien E, Peaceman A, Gibbs R, Swamy G, Norton M, Casey B, Caritis S, Tolosa J, Sorokin Y, VanDorsten J, Jain L. Antenatal Betamethasone for Women at Risk for Late Preterm Delivery. Obstetrical & Gynecological Survey 2016, 71: 453-455. DOI: 10.1097/01.ogx.0000489576.69844.54.Peer-Reviewed Original ResearchLate preterm periodPreterm periodMaternal-Fetal Medicine Units NetworkEunice Kennedy Shriver National InstituteLate preterm deliveryAdministration of betamethasoneAntenatal betamethasoneNeonatal morbidityPreterm deliveryMulticenter trialClinical centersChildhood complicationsChild healthNational InstituteBetamethasoneWomenRiskMorbidityComplicationsNewbornsInfantsAdministrationTrials
2015
Predictors of response to 17-alpha hydroxyprogesterone caproate for prevention of recurrent spontaneous preterm birth
Manuck TA, Esplin MS, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Varner MW, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J, Research E. Predictors of response to 17-alpha hydroxyprogesterone caproate for prevention of recurrent spontaneous preterm birth. American Journal Of Obstetrics And Gynecology 2015, 214: 376.e1-376.e8. PMID: 26692181, PMCID: PMC4803498, DOI: 10.1016/j.ajog.2015.12.010.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPrevious spontaneous preterm birthRecurrent spontaneous preterm birthDelivery gestational ageRecurrent preterm birthPreterm birthSimilar gestational ageGestational ageHydroxyprogesterone caproateSingleton spontaneous preterm birthEarly spontaneous preterm birthFirst-degree family historyPreterm birth preventionHigh-risk womenPlanned secondary analysisPredictors of responseChi-square testPenultimate pregnancyPregnancy characteristicsNeonatal morbidityPregnancy coursePreterm pregnanciesBirth preventionCurrent pregnancyRegression modelsNeonatal complications associated with use of fetal scalp electrode: a retrospective study
Kawakita T, Reddy U, Landy H, Iqbal, Huang C, Grantz K. Neonatal complications associated with use of fetal scalp electrode: a retrospective study. BJOG An International Journal Of Obstetrics & Gynaecology 2015, 123: 1797-1803. PMID: 26643181, PMCID: PMC4899296, DOI: 10.1111/1471-0528.13817.Peer-Reviewed Original ResearchConceptsFetal scalp electrodeVacuum-assisted vaginal deliveryVaginal deliveryOperative vaginal deliveryWeeks of gestationNeonatal complicationsScalp electrodesNeonatal morbidityForceps-assisted vaginal deliveryNon-operative vaginal deliveriesSecondary analysisPrelabour caesarean deliveryRetrospective cohort studyAssisted vaginal deliveryRisk of complicationsSafe Labor studyRisk of injuryCaesarean deliveryPregnancy complicationsCohort studySingleton deliveriesNeonatal risksRetrospective studyUnderlying indicationAbsolute risk