2024
Patient and Community Centered Approaches to Sepsis Among Birthing People
Richardson B, Cepin A, Grilo S, Moss R, Moller M, Brown S, Goffman D, Friedman A, Reddy U, Hall K. Patient and Community Centered Approaches to Sepsis Among Birthing People. Seminars In Perinatology 2024, 151974. PMID: 39341761, DOI: 10.1016/j.semperi.2024.151974.Peer-Reviewed Original ResearchMaternal health equityHealth equityAcademic-community research partnershipsSevere maternal morbidityCo-designed interventionsBirthing peopleMaternal deathsUnderserved communitiesMaternal morbidityMoms studyResearch partnershipsSepsis-related morbidityCommunity centered approachRisk periodResearch principalsResearch processCentered approachCommunityMorbidityPeoplePostpartumInterventionEquityPartnershipBirth
2021
Maternal serum fructosamine levels and stillbirth: a case–control study of the Stillbirth Collaborative Research Network
Arslan E, Allshouse A, Page J, Varner M, Thorsten V, Parker C, Dudley D, Saade G, Goldenberg R, Stoll B, Hogue C, Bukowski R, Conway D, Pinar H, Reddy U, Silver R. Maternal serum fructosamine levels and stillbirth: a case–control study of the Stillbirth Collaborative Research Network. BJOG An International Journal Of Obstetrics & Gynaecology 2021, 129: 619-626. PMID: 34529344, DOI: 10.1111/1471-0528.16922.Peer-Reviewed Original ResearchConceptsSerum fructosamine levelsFructosamine levelsCase-control studyTime of deliveryLive birthsStillbirth Collaborative Research NetworkLive birth controlsCases of stillbirthPotential confounding factorsGeographic catchment areaSingleton stillbirthsGlycaemic controlDiabetes statusMulticentre studyRoutine screeningFructosamine measurementsDiabetesStillbirthConfounding factorsSecondary analysisWomenBirthCollaborative research networksBirth controlResearch Network
2019
Neonatal Outcomes of Elective Early-term Births After Demonstrated Fetal Lung Maturity
Tita A, Jablonski K, Bailit J, Grobman W, Wapner R, Reddy U, Varner M, Thorp J, Leveno K, Caritis S, Iams J, Saade G, Sorokin Y, Rouse D, Blackwell S, Tolosa J. Neonatal Outcomes of Elective Early-term Births After Demonstrated Fetal Lung Maturity. Obstetric Anesthesia Digest 2019, 39: 93-93. DOI: 10.1097/01.aoa.0000557681.76214.2f.Peer-Reviewed Original ResearchFetal lung maturity testingLung maturity testingEarly term birthEarly-term neonatesFetal lung maturityNeonatal outcomesMaturity testingLung maturityAdverse neonatal outcomesFull-term birthFull-term neonatesNeonatal morbidityRespiratory outcomesEarly deliveryAbsence of indicationsNeonatesBirthOutcomesRiskPretermMorbidityTestingNeonatal Outcomes of Elective Early-term Births After Demonstrated Fetal Lung Maturity
Tita A, Jablonski K, Bailit J, Grobman W, Wapner R, Reddy U, Varner M, Thorp J, Leveno K, Caritis S, Iams J, Saade G, Sorokin Y, Rouse D, Blackwell S, Tolosa J. Neonatal Outcomes of Elective Early-term Births After Demonstrated Fetal Lung Maturity. Obstetrical & Gynecological Survey 2019, 74: 66-67. DOI: 10.1097/01.ogx.0000553099.70846.e7.Peer-Reviewed Original Research
2018
Reassessing the Duration of the Second Stage of Labor in Relation to Maternal and Neonatal Morbidity
Grantz K, Sundaram R, Ma L, Hinkle S, Berghella V, Hoffman M, Reddy U. Reassessing the Duration of the Second Stage of Labor in Relation to Maternal and Neonatal Morbidity. Obstetric Anesthesia Digest 2018, 38: 71. DOI: 10.1097/01.aoa.0000532263.77010.0d.Peer-Reviewed Original ResearchNeonatal morbidityInitial cesarean sectionMaternal febrile morbiditySecond-stage arrestMaternal-fetal medicineFebrile morbidityEpidural analgesiaCesarean sectionMultiparous womenNulliparous womenPostpartum hemorrhageVaginal birthAmerican CollegeMorbidityMortalityWomenPresent studyBirthHoursAnalgesiaEpiduralHemorrhagePatientsGynecologistsObstetriciansSmith–Lemli–Opitz Mutations in Unexplained Stillbirths
Gibbins KJ, Reddy UM, Saade GR, Goldenberg RL, Dudley DJ, Parker CB, Thorsten V, Pinar H, Bukowski R, Hogue CJ, Silver RM. Smith–Lemli–Opitz Mutations in Unexplained Stillbirths. American Journal Of Perinatology 2018, 35: 936-939. PMID: 29433144, PMCID: PMC6060008, DOI: 10.1055/s-0038-1626705.Peer-Reviewed Original ResearchConceptsUnexplained stillbirthLive birthsPopulation-based case-control studyCase-control studySmith-LemliAutosomal recessive syndromeObstetric complicationsHistologic featuresExon 3Placental tissueStillbirthRecessive syndromeDeoxyribonucleic acidStrong associationBidirectional sequencingDHCR7 mutationsCompound heterozygotesSyndromeCholesterol biosynthesisOpitz syndromeHomozygote frequencyBirthRepresentative sampleSLOS mutationsDHCR7Reassessing the Duration of the Second Stage of Labor in Relation to Maternal and Neonatal Morbidity
Grantz KL, Sundaram R, Ma L, Hinkle S, Berghella V, Hoffman MK, Reddy UM. Reassessing the Duration of the Second Stage of Labor in Relation to Maternal and Neonatal Morbidity. Obstetrics And Gynecology 2018, 131: 345-353. PMID: 29324600, PMCID: PMC5785437, DOI: 10.1097/aog.0000000000002431.Peer-Reviewed Original ResearchConceptsSpontaneous vaginal birthSecond stage durationVaginal birthNulliparous womenNeonatal complicationsNeonatal morbidityCesarean deliveryFetal heart rate tracingsFirst half hourPrior cesarean deliverySpontaneous vaginal deliveryWeeks of gestationHeart rate tracingsVertex birthsRetrospective cohortMultiparous womenSerious complicationsSerious morbidityVaginal deliveryMorbidityHalf hourLikelihood of birthComplicationsWomenBirth
2017
Altered fetal growth, placental abnormalities, and stillbirth
Bukowski R, Hansen NI, Pinar H, Willinger M, Reddy UM, Parker CB, Silver RM, Dudley DJ, Stoll BJ, Saade GR, Koch MA, Hogue C, Varner MW, Conway DL, Coustan D, Goldenberg RL, . Altered fetal growth, placental abnormalities, and stillbirth. PLOS ONE 2017, 12: e0182874. PMID: 28820889, PMCID: PMC5562325, DOI: 10.1371/journal.pone.0182874.Peer-Reviewed Original ResearchConceptsFetal growth abnormalitiesAltered fetal growthFetal growthLive birthsPlacental abnormalitiesPlacental findingsGrowth abnormalitiesImpaired placental functionSingleton live birthsCase-control studyCause of deathPatterns of associationSingleton stillbirthsPlacental examinationTerm stillbirthGestational ageRisk factorsPerinatal pathologistsPlacental functionClinical careStillbirthAbnormalitiesStandardized protocolBirthDeathPredictive Accuracy of Serial Transvaginal Cervical Lengths and Quantitative Vaginal Fetal Fibronectin Levels for Spontaneous Preterm Birth Among Nulliparous Women
Esplin M, Elovitz M, Iams J, Parker C, Wapner R, Grobman W, Simhan H, Wing D, Haas D, Silver R, Hoffman M, Peaceman A, Caritis S, Parry S, Wadhwa P, Foroud T, Mercer B, Hunter S, Saade G, Reddy U. Predictive Accuracy of Serial Transvaginal Cervical Lengths and Quantitative Vaginal Fetal Fibronectin Levels for Spontaneous Preterm Birth Among Nulliparous Women. Obstetrical & Gynecological Survey 2017, 72: 397-399. DOI: 10.1097/ogx.0000000000000455.Peer-Reviewed Original ResearchPharmacogenomics of 17‐alpha hydroxyprogesterone caproate for recurrent preterm birth: a case–control study
Manuck T, Watkins W, Esplin, Biggio J, Bukowski R, Parry S, Zhan H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy U, Ilekis J, Yandell M, Varner M, Jorde L, Research T. Pharmacogenomics of 17‐alpha hydroxyprogesterone caproate for recurrent preterm birth: a case–control study. BJOG An International Journal Of Obstetrics & Gynaecology 2017, 125: 343-350. PMID: 28139890, DOI: 10.1111/1471-0528.14485.Peer-Reviewed Original ResearchConceptsRecurrent preterm birthPreterm birthSuccessful prolongationDefinition ADefinition BSingleton spontaneous preterm birthSpontaneous preterm birthTertiary care centerCase-control studyWhole-exome sequencingUntreated pregnanciesGestational ageHydroxyprogesterone caproateSignificant prolongationPregnancyExome sequencingProlongationWomenPharmacogenetic genesBirthGene ontology pathwaysIntegrated DiscoveryOntology pathwaysNovel analytic approach
2015
A Genome‐Wide Association Study of Early Spontaneous Preterm Delivery
Zhang H, Baldwin DA, Bukowski RK, Parry S, Xu Y, Song C, Andrews WW, Saade GR, Esplin MS, Sadovsky Y, Reddy UM, Ilekis J, Varner M, Biggio JR, Research F. A Genome‐Wide Association Study of Early Spontaneous Preterm Delivery. Genetic Epidemiology 2015, 39: 217-226. PMID: 25599974, PMCID: PMC4366311, DOI: 10.1002/gepi.21887.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthMaternal single nucleotide polymorphismsSPTB casesPreterm birthValidation cohortSingle nucleotide polymorphismsEarly spontaneous preterm deliveryP-valueTerm controlsTerm delivery controlsSpontaneous preterm deliveryMother-infant pairsCase-control studyIndependent validation cohortRace/ethnicityPreterm deliveryInfant morbidityMaternal ageControl groupMultiple testing adjustmentMultiple comparisonsCohortBirthNucleotide polymorphismsGenome-wide association studies
2013
Bile acids in a multicenter, population-based case-control study of stillbirth
Silver RM, Parker CB, Goldenberg R, Reddy UM, Dudley DJ, Saade GR, Hogue CJ, Coustan D, Varner MW, Koch MA, Conway D, Bukowski R, Pinar H, Stoll B, Moore J, Willinger M. Bile acids in a multicenter, population-based case-control study of stillbirth. American Journal Of Obstetrics And Gynecology 2013, 210: 460.e1-460.e9. PMID: 24215860, PMCID: PMC4413928, DOI: 10.1016/j.ajog.2013.11.017.Peer-Reviewed Original ResearchConceptsPopulation-based case-control studyBile acid levelsCase-control studyLive birthsBile acidsStillbirth Collaborative Research NetworkAcid levelsBaseline risk factorsTerm live birthsPopulation-based studyCases of stillbirthTime of enrollmentProportion of womenMaternal serumClinical evidenceIntrahepatic cholestasisRisk factorsFetal anomaliesStillbirthElevated levelsWomenBirthSimilar proportionsCollaborative research networksResearch Network
2000
Population adjustment of the definition of the vaginal birth after cesarean rate
Reddy U, DiVito M, Armstrong J, Hyslop T, Wapner R. Population adjustment of the definition of the vaginal birth after cesarean rate. American Journal Of Obstetrics And Gynecology 2000, 183: 1166-1169. PMID: 11084560, DOI: 10.1067/mob.2000.109050.Peer-Reviewed Original ResearchConceptsTrial of laborCesarean delivery rateMaternal-fetal medicine servicePrevious cesarean deliveryVaginal birthCesarean deliveryMedicine servicePatient's risk statusDelivery rateResident clinicCesarean rateNoncandidatesClinical servicesRisk statusTrialsBirthImpact of adjustmentWomenHigh percentagePrivate servicesDeliveryClinicPercentageRate