2017
Proteomics data on MAP Kinase Kinase 3 knock out bone marrow derived macrophages exposed to cigarette smoke extract
Srivastava R, Mannam P, Rauniyar N, Lam TT, Luo R, Lee PJ, Srivastava A. Proteomics data on MAP Kinase Kinase 3 knock out bone marrow derived macrophages exposed to cigarette smoke extract. Data In Brief 2017, 13: 320-325. PMID: 28653025, PMCID: PMC5476452, DOI: 10.1016/j.dib.2017.05.049.Peer-Reviewed Original ResearchMAP kinase kinase 3Yale Protein Expression DatabaseKinase 3Protein Expression DatabaseAbsolute quantitation (iTRAQ) reagentsIngenuity Pathway Analysis softwarePathway Analysis softwareTotal proteomeCellular proteinsIsobaric tagsProteomic dataMAP kinaseCanonical pathwaysMolecular networksCigarette smoke extractProteome DiscovererMass spectrometry dataBone marrowExpression databaseLC-MS/MSSpectrometry dataPathwaySmoke extractPhosphoproteomeProteome
2016
MKK3 influences mitophagy and is involved in cigarette smoke-induced inflammation
Mannam P, Rauniyar N, Lam TT, Luo R, Lee PJ, Srivastava A. MKK3 influences mitophagy and is involved in cigarette smoke-induced inflammation. Free Radical Biology And Medicine 2016, 101: 102-115. PMID: 27717867, DOI: 10.1016/j.freeradbiomed.2016.10.001.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsCigarette SmokingGene Expression ProfilingGene Expression RegulationHumansInflammationInterleukin-1betaInterleukin-6MacrophagesMAP Kinase Kinase 3MiceMice, Inbred C57BLMice, KnockoutMitochondriaMitophagyNF-kappa BOxidative PhosphorylationPlant ExtractsPrimary Cell CulturePulmonary Disease, Chronic ObstructiveReactive Oxygen SpeciesTobaccoTumor Necrosis Factor-alphaConceptsCigarette smoke extractCigarette smokeCSE treatmentInflammatory responseLung tissueCigarette smoke-induced inflammationWild typeSerum pro-inflammatory cytokinesSmoke-induced inflammationProgression of COPDMitochondrial dysfunctionReactive oxygen speciesPro-inflammatory cytokinesInflammatory cytokine productionPrimary risk factorAssociated inflammatory responsePatient's lung tissueMouse lung tissueMitochondrial functionDual-specificity protein kinaseRespiratory capacitySpare respiratory capacityAirflow obstructionProtein kinase kinase 3CSE exposure