2021
Altered hippocampal astroglial metabolism is associated with aging and preserved spatial learning and memory
Ebersole J, Rose G, Eid T, Behar K, Patrylo P. Altered hippocampal astroglial metabolism is associated with aging and preserved spatial learning and memory. Neurobiology Of Aging 2021, 102: 188-199. PMID: 33774381, DOI: 10.1016/j.neurobiolaging.2021.02.015.Peer-Reviewed Original ResearchConceptsArtificial cerebrospinal fluidAstroglial metabolismNeural metabolismHippocampus-dependent cognitive functionGlutamate-glutamine cyclingFischer 344 ratsHippocampus-dependent learningAge-related decreaseAU ratsCognitive functionLiquid chromatography-tandem mass spectroscopyGlutamatergic neurotransmissionCognitive declineHippocampal slicesSpatial learningCognitive statusHippocampal subregionsCerebrospinal fluidImpaired ratsMetabolism correlateYoung adultsCompensatory changesRatsC-glucoseMemory
2020
Gene expression in the epileptic (EL) mouse hippocampus
Lee TS, Li AY, Rapuano A, Mantis J, Eid T, Seyfried TN, de Lanerolle NC. Gene expression in the epileptic (EL) mouse hippocampus. Neurobiology Of Disease 2020, 147: 105152. PMID: 33153970, DOI: 10.1016/j.nbd.2020.105152.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyHuman temporal lobe epilepsySeizure focusHippocampal seizure focusRole of neurogliaExtensive neuronal lossMolecular changesEpileptic miceMicroglial activationNeuronal lossNeuron lossEl miceLobe epilepsySeizure modelHippocampal fieldsSeizure generationPathological changesPaucity of studiesMouse hippocampusAnimal modelsHeat shock proteinsNormal populationPathological processesExpression levelsEpilepsy
2000
Neurons in Layer III of the Entorhinal Cortex: A Role in Epileptogenesis and Epilepsy?
SCHWARCZ R, EID T, DU F. Neurons in Layer III of the Entorhinal Cortex: A Role in Epileptogenesis and Epilepsy? Annals Of The New York Academy Of Sciences 2000, 911: 328-342. PMID: 10911883, DOI: 10.1111/j.1749-6632.2000.tb06735.x.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyEntorhinal cortexLayer IIILobe epilepsySeizure-induced cell deathProminent excitatory inputSeizure-induced deathLayer III neuronsAminooxyacetic acidAOAA injectionPreferential lesionGABAergic neuronsNeuron lossLimbic structuresExcitatory inputsPathological changesParahippocampal structuresAnimal modelsEpilepsyNeuronsLesionsCell deathCortexDeathInjection
1997
Neuronal damage after the injection of amino-oxyacetic acid into the rat entorhinal cortex: a silver impregnation study
Du F, Eid T, Schwarcz R. Neuronal damage after the injection of amino-oxyacetic acid into the rat entorhinal cortex: a silver impregnation study. Neuroscience 1997, 82: 1165-1178. PMID: 9466438, DOI: 10.1016/s0306-4522(97)00354-0.Peer-Reviewed Original ResearchConceptsSilver-stained neuronsTemporal lobe epilepsyEntorhinal cortexAcid injectionNeuronal damageLobe epilepsyLayer IIIProlonged seizure activitySilver impregnation studyReactive glial cellsPattern of neurodegenerationHippocampal CA1 fieldLateral amygdaloid nucleusRat entorhinal cortexAminooxyacetic acidAmino-oxyacetic acidMedial entorhinal cortexDegenerated neuronsNeuropathological consequencesDamaged neuronsSeizure activityAmygdaloid nucleusMost neuronsNeuronal deathCA1 field
1995
Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy
Du F, Eid T, Lothman E, Kohler C, Schwarcz R. Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy. Journal Of Neuroscience 1995, 15: 6301-6313. PMID: 7472396, PMCID: PMC6577998, DOI: 10.1523/jneurosci.15-10-06301.1995.Peer-Reviewed Original ResearchConceptsPreferential neuronal lossTemporal lobe epilepsyNeuronal lossMedial entorhinal cortexEntorhinal cortexLayer IIILobe epilepsyRat modelIntractable temporal lobe epilepsyAcute status epilepticusLithium/pilocarpineParvalbumin-positive neuronsIntracellular calcium ion concentrationKainic acid administrationNerve cell lossAdult male ratsInjection of diazepamSurviving neuronsProlonged seizuresStatus epilepticusAcid administrationNissl stainingVentral hippocampusKainic acidPathological elevationDifferential neuronal vulnerability to amino-oxyacetate and quinolinate in the rat parahippocampal region
Eid T, Du F, Schwarcz R. Differential neuronal vulnerability to amino-oxyacetate and quinolinate in the rat parahippocampal region. Neuroscience 1995, 68: 645-656. PMID: 8577365, DOI: 10.1016/0306-4522(95)00183-j.Peer-Reviewed Original ResearchConceptsAcute behavioral seizuresBehavioral seizuresDizocilpine maleateNeuronal lossEntorhinal cortexEndogenous N-methyl-D-aspartate receptor agonistN-methyl-D-aspartate receptor antagonist dizocilpine maleateLayer IIIN-methyl-D-aspartate receptor agonistParahippocampal regionN-methyl-D-aspartate (NMDA) receptor subtypeDifferential neuronal vulnerabilityDorsal perirhinal cortexPreferential neuronal lossTemporal lobe epilepsyChloral hydrate anesthesiaLower anesthetic doseNeuropathological sequelaeLobe epilepsyNeuropathological changesLayer VNeuronal vulnerabilityPreferential degenerationAnesthetic doseReceptor agonist