α,β‐Dehydrogenation Adjacent to Sulfur‐ and Phosphorus‐ Containing Compounds
Sun Y, Newhouse T. α,β‐Dehydrogenation Adjacent to Sulfur‐ and Phosphorus‐ Containing Compounds. Angewandte Chemie 2024 DOI: 10.1002/ange.202411859.Peer-Reviewed Original ResearchAllyl methyl carbonateDeuterium incorporation studiesOrganozinc intermediatesMethyl carbonateReaction sequencePhosphorus-containing compoundsSide productsPhosphorus groupsReaction optimizationReactionSulfurDiverse array of substratesArray of substratesDiastereoselectivitiesSubstrateDeuteriumFormationIntermediateCompoundsα,β‐Dehydrogenation Adjacent to Sulfur‐ and Phosphorus‐ Containing Compounds
Sun Y, Newhouse T. α,β‐Dehydrogenation Adjacent to Sulfur‐ and Phosphorus‐ Containing Compounds. Angewandte Chemie International Edition 2024, e202411859. PMID: 39264684, DOI: 10.1002/anie.202411859.Peer-Reviewed Original ResearchAllyl methyl carbonateDeuterium incorporation studiesOrganozinc intermediatesMethyl carbonateReaction sequencePhosphorus-containing compoundsSide productsPhosphorus groupsReaction optimizationReactionSulfurDiverse array of substratesArray of substratesDiastereoselectivitiesSubstrateDeuteriumFormationIntermediateCompoundsComprehensive Mechanistic Analysis of Palladium- and Nickel-Catalyzed α,β-Dehydrogenation of Carbonyls via Organozinc Intermediates
Bodnar A, Szewczyk S, Sun Y, Chen Y, Huang A, Newhouse T. Comprehensive Mechanistic Analysis of Palladium- and Nickel-Catalyzed α,β-Dehydrogenation of Carbonyls via Organozinc Intermediates. The Journal Of Organic Chemistry 2024, 89: 3123-3132. PMID: 38377547, PMCID: PMC11000628, DOI: 10.1021/acs.joc.3c02572.Peer-Reviewed Original ResearchOrganozinc intermediatesOrganic synthesisC-C bond formationElectron-withdrawing groupsReactivity of PdAdjacent electron‐withdrawing groupConversion of alkanesAnalysis of palladiumNickel catalysisDFT calculationsKIE experimentsStoichiometric reactionBond formationReaction typesSmall moleculesComprehensive mechanistic analysisPalladiumDegree of unsaturationCentral transformationEfficient strategyIntermediateRate studiesReactionSynthesisPd