Comprehensive Mechanistic Analysis of Palladium- and Nickel-Catalyzed α,β-Dehydrogenation of Carbonyls via Organozinc Intermediates
Bodnar A, Szewczyk S, Sun Y, Chen Y, Huang A, Newhouse T. Comprehensive Mechanistic Analysis of Palladium- and Nickel-Catalyzed α,β-Dehydrogenation of Carbonyls via Organozinc Intermediates. The Journal Of Organic Chemistry 2024, 89: 3123-3132. PMID: 38377547, PMCID: PMC11000628, DOI: 10.1021/acs.joc.3c02572.Peer-Reviewed Original ResearchOrganozinc intermediatesOrganic synthesisC-C bond formationElectron-withdrawing groupsReactivity of PdAdjacent electron‐withdrawing groupConversion of alkanesAnalysis of palladiumNickel catalysisDFT calculationsKIE experimentsStoichiometric reactionBond formationReaction typesSmall moleculesComprehensive mechanistic analysisPalladiumDegree of unsaturationCentral transformationEfficient strategyIntermediateRate studiesReactionSynthesisPd