2023
Interaction Between Frailty and Dementia—Reply
Gill T, Vander Wyk B, Becher R. Interaction Between Frailty and Dementia—Reply. JAMA Surgery 2023, 158: 889-889. PMID: 37017979, DOI: 10.1001/jamasurg.2023.0381.Commentaries, Editorials and LettersAssociation of frailty with the incidence risk of cardiovascular disease and type 2 diabetes mellitus in long-term cancer survivors: a prospective cohort study
Cao X, Yang Z, Li X, Chen C, Hoogendijk E, Zhang J, Yao N, Ma L, Zhang Y, Zhu Y, Zhang X, Du Y, Wang X, Wu X, Gill T, Liu Z. Association of frailty with the incidence risk of cardiovascular disease and type 2 diabetes mellitus in long-term cancer survivors: a prospective cohort study. BMC Medicine 2023, 21: 74. PMID: 36829175, PMCID: PMC9951842, DOI: 10.1186/s12916-023-02774-1.Peer-Reviewed Original ResearchConceptsLong-term cancer survivorsType 2 diabetes mellitusCancer survivorsCardiovascular diseaseIncidence riskDiabetes mellitusFrailty IndicatorCox proportional hazards regression modelRisk of CVDProportional hazards regression modelsNon-frail participantsSerious healthcare burdenIncident cardiovascular diseaseMultivariable-adjusted modelsProspective cohort studyAssociation of frailtyPrimary care dataHazards regression modelsTime of recruitmentQuality of lifeLater comorbidityIncident T2DMCohort studyFrailty phenotypeFrailty indexPlatelet response to influenza vaccination reflects effects of aging
Konstorum A, Mohanty S, Zhao Y, Melillo A, Vander Wyk B, Nelson A, Tsang S, Blevins T, Belshe R, Chawla D, Rondina M, Gill T, Montgomery R, Allore H, Kleinstein S, Shaw A. Platelet response to influenza vaccination reflects effects of aging. Aging Cell 2023, 22: e13749. PMID: 36656789, PMCID: PMC9924941, DOI: 10.1111/acel.13749.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAgingBlood PlateletsFrail ElderlyFrailtyHumansInfant, NewbornInfluenza, HumanVaccinationYoung AdultConceptsCommunity-dwelling older adultsPlatelet activationOlder adultsInfluenza vaccinationAge-associated chronic inflammationInfluence platelet functionRNA expressionPro-inflammatory diseasesAge-associated increasePlatelet activation pathwaysAge-associated differencesActivation pathwayPlatelet transcriptomeGeriatric conditionsChronic inflammationImmune responsePlatelet functionPlatelet responseSNF residentsVaccinationActivation responseYoung individualsProtein levelsAdultsYounger participants
2019
Short-Term Disability Fluctuations in Late Life
Stolz E, Gill T, Mayerl H, Freidl W. Short-Term Disability Fluctuations in Late Life. The Journals Of Gerontology Series B 2019, 74: e135-e140. PMID: 31298701, PMCID: PMC6777769, DOI: 10.1093/geronb/gbz089.Peer-Reviewed Original Research
2015
The role of intervening hospital admissions on trajectories of disability in the last year of life: prospective cohort study of older people
Gill TM, Gahbauer EA, Han L, Allore HG. The role of intervening hospital admissions on trajectories of disability in the last year of life: prospective cohort study of older people. The BMJ 2015, 350: h2361. PMID: 25995357, PMCID: PMC4443433, DOI: 10.1136/bmj.h2361.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedCohort StudiesConnecticutDementiaDisability EvaluationDisabled PersonsDisease ProgressionFemaleFrail ElderlyGeriatric AssessmentHospitalizationHumansMaleMultiple Organ FailureNeoplasmsPrognosisProspective StudiesSeverity of Illness IndexTerminal CareUnited StatesConceptsCourse of disabilityProspective cohort studyHospital admissionTrajectories of disabilitySeverity of disabilityCatastrophic disabilitySevere disabilityCohort studyAcute hospital admissionPalliative care approachMultiple hospital admissionsAdvance care planningPersonal care needsEnd of lifeDisability scoresOlder patientsPotential confoundersOccurrence of admissionMultivariable modelCare planningMAIN OUTCOMECare approachDaily livingCare needsAdmission
2014
Disentangling the Disabling Process: Insights From the Precipitating Events Project
Gill TM. Disentangling the Disabling Process: Insights From the Precipitating Events Project. The Gerontologist 2014, 54: 533-549. PMID: 25035454, PMCID: PMC4155452, DOI: 10.1093/geront/gnu067.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsActivities of Daily LivingAgedDisability EvaluationDisabled PersonsFrail ElderlyHumansProblem SolvingConceptsHealth care utilizationPrecipitating Events ProjectPEP studyOlder personsCare utilizationEpidemiology of disabilityCommunity-living personsHome-based assessmentFrequency of assessmentDisability episodeEnd of lifeFunctional statusDaily livingOngoing longitudinal studyMedicare dataDisabling processEffective interventionsLonger durationLongitudinal studyDisabilityRecent linkageEvents ProjectPersonsSymptomsMorbid
2010
Change in Disability After Hospitalization or Restricted Activity in Older Persons
Gill TM, Allore HG, Gahbauer EA, Murphy TE. Change in Disability After Hospitalization or Restricted Activity in Older Persons. JAMA 2010, 304: 1919-1928. PMID: 21045098, PMCID: PMC3124926, DOI: 10.1001/jama.2010.1568.Peer-Reviewed Original ResearchConceptsHazard ratioPhysical frailtySevere disabilityOlder personsMild disabilityMultivariable hazard ratiosProspective cohort studyCommunity-living personsFall-related injuriesGreater New HavenState of disabilityLikelihood of recoveryCohort studyAbsolute riskFrail individualsHospitalizationDaily livingNonfrail individualsRestricted activityInjuryTelephone interviewsFrailtyIllnessMonthsDisability
2009
Indications, Labeling, and Outcomes Assessment for Drugs Aimed at Improving Functional Status in Older Persons: A Conversation Between Aging Researchers and FDA Regulators
Bhasin S, Espeland M, Evans W, Ferrucci L, Fried L, Gill T, Pahor M, Studenski S, Guralnik J, Nayfield S, Romashkin S, Perlstein R, Burke L, Parks M. Indications, Labeling, and Outcomes Assessment for Drugs Aimed at Improving Functional Status in Older Persons: A Conversation Between Aging Researchers and FDA Regulators. The Journals Of Gerontology Series A 2009, 64A: 487-491. PMID: 19270182, PMCID: PMC2657175, DOI: 10.1093/gerona/gln042.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsActivities of Daily LivingAgedAged, 80 and overAgingCognition DisordersDose-Response Relationship, DrugFemaleFrail ElderlyGeriatric AssessmentHumansInterdisciplinary CommunicationMaleOutcome Assessment, Health CarePharmaceutical PreparationsPhysical FitnessPractice Guidelines as TopicResearchRisk AssessmentSensitivity and SpecificityUnited StatesUnited States Food and Drug Administration
2004
Hospitalization, Restricted Activity, and the Development of Disability Among Older Persons
Gill TM, Allore HG, Holford TR, Guo Z. Hospitalization, Restricted Activity, and the Development of Disability Among Older Persons. JAMA 2004, 292: 2115-2124. PMID: 15523072, DOI: 10.1001/jama.292.17.2115.Peer-Reviewed Original ResearchConceptsDevelopment of disabilityPhysical frailtyRestricted activityDaily livingOlder personsProspective cohort studyMonthly telephone interviewsMonths of hospitalizationPopulation attributable fractionGreater New HavenPrevention of disabilityOccurrence of disabilityCohort studyFrail participantsHospital admissionNonfrail participantsMultivariable hazardMAIN OUTCOMEDisabling processHospitalizationTelephone interviewsDisability onsetGeneral communityOlder adultsFrailty
2002
A Program to Prevent Functional Decline in Physically Frail, Elderly Persons Who Live at Home
Gill TM, Baker DI, Gottschalk M, Peduzzi PN, Allore H, Byers A. A Program to Prevent Functional Decline in Physically Frail, Elderly Persons Who Live at Home. New England Journal Of Medicine 2002, 347: 1068-1074. PMID: 12362007, DOI: 10.1056/nejmoa020423.Peer-Reviewed Original ResearchConceptsFunctional declineControl groupElderly personsDisability scoresIntervention groupLower-body dressingMore severe disabilityPrevent Functional DeclineHome-based intervention programFrequency of admissionHome-based programSuch functional declinePersons 75 yearsBase lineSevere frailtyPrimary outcomeSubstantial morbidityModerate frailtyMuscle strengthDisability ScalePhysical abilityPhysical therapyDaily livingNursing homesSix months
2001
Two Recruitment Strategies for a Clinical Trial of Physically Frail Community‐Living Older Persons
Gill T, McGloin J, Gahbauer E, Shepard D, Bianco L. Two Recruitment Strategies for a Clinical Trial of Physically Frail Community‐Living Older Persons. Journal Of The American Geriatrics Society 2001, 49: 1039-1045. PMID: 11555064, DOI: 10.1046/j.1532-5415.2001.49206.x.Peer-Reviewed Original ResearchConceptsOffice-based strategiesCommunity-living personsPrimary care physiciansPhysical frailtyNumber of personsCare physiciansClinical trialsAge 75Older personsRefusal rateRecruitment strategiesSlow gait speedLower extremity functionPotential participantsQuadriceps weaknessRandomized participantsOffice visitsGait speedMean ageFrail communityFrailtyPatient rosterGeneral communityPhysiciansTrials
1999
Mismatches Between the Home Environment and Physical Capabilities Among Community‐Living Older Persons
Gill T, Robison J, Williams C, Tinetti M. Mismatches Between the Home Environment and Physical Capabilities Among Community‐Living Older Persons. Journal Of The American Geriatrics Society 1999, 47: 88-92. PMID: 9920235, DOI: 10.1111/j.1532-5415.1999.tb01906.x.Peer-Reviewed Original ResearchConceptsOlder personsHomes of participantsCommunity-living older personsTub/showerAdverse functional outcomesPopulation-based cohortCross-sectional studySame deficitSpecific deficitsPhysical performance assessmentPhysical capabilitiesFunctional outcomeEpidemiologic linkGeneral communityPrevalenceComprehensive interviewObstructed pathwaysDeficitsEveryday functionGrab barsObserved deficitsParticipantsGaitPersonsNew Haven