2024
In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization
Kaushik R, McAvay G, Murphy T, Acampora D, Araujo K, Charpentier P, Chattopadhyay S, Geda M, Gill T, Kaminski T, Lee S, Li J, Cohen A, Hajduk A, Ferrante L. In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization. JAMA Network Open 2024, 7: e2419640. PMID: 38954414, PMCID: PMC11220565, DOI: 10.1001/jamanetworkopen.2024.19640.Peer-Reviewed Original ResearchConceptsIn-hospital deliriumChart-Based Delirium Identification InstrumentOlder adultsFunctional disabilityCOVID-19 hospitalizationCognitive impairmentCohort studyAssociated with increased functional disabilityHospitalized older adultsIncreased functional disabilityAssociation of deliriumPostdischarge follow-upRisk of deliriumTertiary care systemFollow-upPresence of cognitive impairmentProspective cohort studyLogistic regression modelsOlder survivorsCare systemIncreasing cognitive impairmentMain OutcomesCOVID-19Hospital dischargePrimary outcome
2023
Assessment of Regional Nursing Home Preparedness for and Regulatory Responsiveness to Wildfire Risk in the Western US
Festa N, Throgmorton K, Davis-Plourde K, Dosa D, Chen K, Zang E, Kelly J, Gill T. Assessment of Regional Nursing Home Preparedness for and Regulatory Responsiveness to Wildfire Risk in the Western US. JAMA Network Open 2023, 6: e2320207. PMID: 37358851, PMCID: PMC10293909, DOI: 10.1001/jamanetworkopen.2023.20207.Peer-Reviewed Original ResearchConceptsCross-sectional studyNursing homesNursing home characteristicsMean survival timeUS nursing homesGreater mean numberPrimary outcomeUS CentersExposure statusMAIN OUTCOMEElevated riskSurvival timeSurvival analysisPresence of deficienciesMore deficienciesRisk statusEmergency preparednessHome characteristicsMean numberRiskPreparedness standardsDeficiencyResponsivenessHigh percentageOutcomesPragmatic evaluation of events and benefits of lipid lowering in older adults (PREVENTABLE): Trial design and rationale
Joseph J, Pajewski N, Dolor R, Sellers M, Perdue L, Peeples S, Henrie A, Woolard N, Jones W, Benziger C, Orkaby A, Mixon A, VanWormer J, Shapiro M, Kistler C, Polonsky T, Chatterjee R, Chamberlain A, Forman D, Knowlton K, Gill T, Newby L, Hammill B, Cicek M, Williams N, Decker J, Ou J, Rubinstein J, Choudhary G, Gazmuri R, Schmader K, Roumie C, Vaughan C, Effron M, Cooper‐DeHoff R, Supiano M, Shah R, Whittle J, Hernandez A, Ambrosius W, Williamson J, Alexander K, Group P. Pragmatic evaluation of events and benefits of lipid lowering in older adults (PREVENTABLE): Trial design and rationale. Journal Of The American Geriatrics Society 2023, 71: 1701-1713. PMID: 37082807, PMCID: PMC10258159, DOI: 10.1111/jgs.18312.Peer-Reviewed Original ResearchConceptsOlder adultsHigh-intensity statin therapyRandomized pragmatic clinical trialCognitive testingBenefits of lipidInitiation of statinsBenefits of statinsNational Death Index searchEffect of statinsPragmatic clinical trialsCommunity-dwelling adultsMild cognitive impairmentLow participant burdenBaseline cognitive testingElectronic health recordsCardiovascular deathCardiovascular eventsCoronary revascularizationLipid panelStatin therapyStatin useUnstable anginaHeart failurePrimary outcomeMyocardial infarction
2022
Effect of Structured, Moderate Exercise on Kidney Function Decline in Sedentary Older Adults
Shlipak M, Sheshadri A, Hsu F, Chen S, Jotwani V, Tranah G, Fielding R, Liu C, Ix J, Coca S, Pahor M, Guralnik J, Leeuwenburgh C, Caudle C, Crump L, Holmes L, Leeuwenburgh J, Lu C, Miller M, Espeland M, Ambrosius W, Applegate W, Beavers D, Byington R, Cook D, Furberg C, Harvin L, Henkin L, Hepler J, Hsu F, Lovato L, Roberson W, Rushing J, Rushing S, Stowe C, Walkup M, Hire D, Rejeski W, Katula J, Brubaker P, Mihalko S, Jennings J, Hadley E, Romashkan S, Patel K, Bonds D, McDermott M, Spring B, Hauser J, Kerwin D, Domanchuk K, Graff R, Rego A, Church T, Blair S, Myers V, Monce R, Britt N, Harris M, McGucken A, Rodarte R, Millet H, Tudor-Locke C, Butitta B, Donatto S, Cocreham S, King A, Castro C, Haskell W, Stafford R, Pruitt L, Berra K, Yank V, Fielding R, Nelson M, Folta S, Phillips E, Liu C, McDavitt E, Reid K, Kirn D, Pasha E, Kim W, Beard V, Tsiroyannis E, Hau C, Manini T, Anton S, Nayfield S, Buford T, Marsiske M, Sandesara B, Knaggs J, Lorow M, Marena W, Korytov I, Morris H, Fitch M, Singletary F, Causer J, Radcliff K, Newman A, Studenski S, Goodpaster B, Glynn N, Lopez O, Nadkarni N, Williams K, Newman M, Grove G, Bonk J, Rushing J, Kost P, Ives D, Kritchevsky S, Marsh A, Brinkley T, Demons J, Sink K, Kennedy K, Shertzer-Skinner R, Wrights A, Fries R, Barr D, Gill T, Axtell R, Kashaf S, de Rekeneire N, McGloin J, Wu K, Shepard D, Fennelly B, Iannone L, Mautner R, Sweeney Barnett T, Halpin S, Brennan M, Bugaj J, Zenoni M, Mignosa B, Williamson J, Hendrie H, Rapp S, Verghese J, Woolard N, Espeland M, Jennings J, Wilson V, Pepine C, Ariet M, Handberg E, Deluca D, Hill J, Szady A, Chupp G, Flynn G, Hankinson J, Vaz Fragoso C, Groessl E, Kaplan R. Effect of Structured, Moderate Exercise on Kidney Function Decline in Sedentary Older Adults. JAMA Internal Medicine 2022, 182: 650-659. PMID: 35499834, PMCID: PMC9062767, DOI: 10.1001/jamainternmed.2022.1449.Peer-Reviewed Original ResearchConceptsKidney function declineExercise interventionSedentary older adultsPhysical activityFunction declineOlder adultsClinical trialsHealth education control interventionModerate-intensity physical activityModerate-intensity exercise interventionAncillary analysisGlomerular filtration rateRandomized clinical trialsHigh physical activityModerate-intensity exerciseModerate-intensity activityCystatin C changesLifestyle interventionPrimary outcomeLarge trialsMean ageFiltration rateModerate exerciseOriginal trialMAIN OUTCOME
2020
A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries
Bhasin S, Gill TM, Reuben DB, Latham NK, Ganz DA, Greene EJ, Dziura J, Basaria S, Gurwitz JH, Dykes PC, McMahon S, Storer TW, Gazarian P, Miller ME, Travison TG, Esserman D, Carnie MB, Goehring L, Fagan M, Greenspan SL, Alexander N, Wiggins J, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace RB, Casteel C, Resnick NM, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Meng C, Allore H, Brawley BF, Eder R, McGloin JM, Skokos EA, Duncan PW, Baker D, Boult C, Correa-de-Araujo R, Peduzzi P. A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries. New England Journal Of Medicine 2020, 383: 129-140. PMID: 32640131, PMCID: PMC7421468, DOI: 10.1056/nejmoa2002183.Peer-Reviewed Original ResearchConceptsSerious fall injuriesFall injuriesIntervention groupControl groupUsual careMultifactorial interventionRate of hospitalizationPrimary care practicesCluster-randomized trialCommunity-dwelling adultsFirst-event analysisYears of ageHealth care systemRate of fallElectronic health recordsBaseline characteristicsPrimary outcomeRandomized trialsMean ageEfficacy trialsIndividualized planCare practicesInjuryMultifactorial strategyEvent rates
2017
STRIDE: ASCERTAINING SERIOUS FALL-RELATED INJURIES IN A PRAGMATIC TRIAL OF FALL PREVENTION
Ganz D, Siu A, Magaziner J, Travison T, Gill T, Latham N. STRIDE: ASCERTAINING SERIOUS FALL-RELATED INJURIES IN A PRAGMATIC TRIAL OF FALL PREVENTION. Innovation In Aging 2017, 1: 1008-1008. PMCID: PMC6184873, DOI: 10.1093/geroni/igx004.3659.Peer-Reviewed Original ResearchSerious fall injuriesFall injuriesMedical attentionFalls/injuriesMonthly fall calendarsType of injuryFall calendarsPrimary outcomeClinical featuresPragmatic trialMedical recordsFall preventionInjurySerious fallsTelephone interviewsParticipants' reportsAscertainment biasParticipantsPatientsTrialsFallMonthsPrevention
2016
Effects of Testosterone Treatment in Older Men
Snyder PJ, Bhasin S, Cunningham GR, Matsumoto AM, Stephens-Shields AJ, Cauley JA, Gill TM, Barrett-Connor E, Swerdloff RS, Wang C, Ensrud KE, Lewis CE, Farrar JT, Cella D, Rosen RC, Pahor M, Crandall JP, Molitch ME, Cifelli D, Dougar D, Fluharty L, Resnick SM, Storer TW, Anton S, Basaria S, Diem SJ, Hou X, Mohler ER, Parsons JK, Wenger NK, Zeldow B, Landis JR, Ellenberg SS. Effects of Testosterone Treatment in Older Men. New England Journal Of Medicine 2016, 374: 611-624. PMID: 26886521, PMCID: PMC5209754, DOI: 10.1056/nejmoa1506119.Peer-Reviewed Original ResearchConceptsMid-normal rangeMen 65 yearsSerum testosterone concentrationsYears of ageTestosterone treatmentTestosterone levelsTestosterone concentrationsMen 19Depressive symptomsOlder menChronic Illness Therapy-Fatigue ScalePsychosexual Daily QuestionnaireSerum testosterone levelsPercentage of menAdverse eventsErectile functionPrimary outcomePlacebo gelSexual functionStudy groupWalking distanceFunctional assessmentMen ageModerate benefitDaily questionnaires
2002
A Program to Prevent Functional Decline in Physically Frail, Elderly Persons Who Live at Home
Gill TM, Baker DI, Gottschalk M, Peduzzi PN, Allore H, Byers A. A Program to Prevent Functional Decline in Physically Frail, Elderly Persons Who Live at Home. New England Journal Of Medicine 2002, 347: 1068-1074. PMID: 12362007, DOI: 10.1056/nejmoa020423.Peer-Reviewed Original ResearchConceptsFunctional declineControl groupElderly personsDisability scoresIntervention groupLower-body dressingMore severe disabilityPrevent Functional DeclineHome-based intervention programFrequency of admissionHome-based programSuch functional declinePersons 75 yearsBase lineSevere frailtyPrimary outcomeSubstantial morbidityModerate frailtyMuscle strengthDisability ScalePhysical abilityPhysical therapyDaily livingNursing homesSix months
1999
The Combined Effects of Baseline Vulnerability and Acute Hospital Events on the Development of Functional Dependence Among Community-Living Older Persons
Gill T, Williams C, Tinetti M. The Combined Effects of Baseline Vulnerability and Acute Hospital Events on the Development of Functional Dependence Among Community-Living Older Persons. The Journals Of Gerontology Series A 1999, 54: m377-m383. PMID: 10462171, DOI: 10.1093/gerona/54.7.m377.Peer-Reviewed Original ResearchConceptsCommunity-living older personsValidation cohortDevelopment cohortOlder personsBaseline vulnerabilityHospital eventsPopulation-based cohort studyAcute care hospital admissionsCommunity-living personsHigh-risk groupSkilled nursing facilitiesYears of ageCohort studyHospital admissionPrimary outcomeComparable personsNew disabilityDaily livingNursing facilitiesCohortCognitive statusHigh-vulnerability groupPrecipitating eventsPhysical performanceAdmission