2023
Association of Poor Oral Health With Neuroimaging Markers of White Matter Injury in Middle-Aged Participants in the UK Biobank.
Rivier C, Renedo D, de Havenon A, Sunmonu N, Gill T, Payabvash S, Sheth K, Falcone G. Association of Poor Oral Health With Neuroimaging Markers of White Matter Injury in Middle-Aged Participants in the UK Biobank. Neurology 2023, 102: e208010. PMID: 38165331, PMCID: PMC10870735, DOI: 10.1212/wnl.0000000000208010.Peer-Reviewed Original ResearchConceptsPoor oral healthOral healthBrain healthRisk factorsNeuroimaging markerWMH volumeHealth profileMD scoreSelf-reported poor oral healthCross-sectional neuroimaging studiesFractional anisotropyWhite matter hyperintensity volumeModifiable risk factorsWhite matter injuryPresence of denturesMendelian randomizationMiddle-aged personsFA scoreMiddle-aged participantsLoose teethCardiovascular diseaseHyperintensity volumeBrain MRIModifiable processEarly interventionAssociations Between Frailty and the Increased Risk of Adverse Outcomes Among 38,950 UK Biobank Participants With Prediabetes: Prospective Cohort Study
Cao X, Li X, Zhang J, Sun X, Yang G, Zhao Y, Li S, Hoogendijk E, Wang X, Zhu Y, Allore H, Gill T, Liu Z. Associations Between Frailty and the Increased Risk of Adverse Outcomes Among 38,950 UK Biobank Participants With Prediabetes: Prospective Cohort Study. JMIR Public Health And Surveillance 2023, 9: e45502. PMID: 37200070, PMCID: PMC10236284, DOI: 10.2196/45502.Peer-Reviewed Original ResearchConceptsMultiple adverse outcomesChronic kidney diseaseDiabetes-related microvascular diseaseAdverse outcomesCause mortalityCardiovascular diseaseMiddle-aged adultsUK Biobank participantsHigh riskMicrovascular diseaseEye diseaseIncident type 2 diabetes mellitusType 2 diabetes mellitusProportional hazards regression modelsBiobank participantsMultivariable-adjusted modelsProspective cohort studyHazards regression modelsNormal glucose metabolismDiabetes-related burdenDiabetes-related diseasesHealth care resourcesNonfrail counterpartsFrailty assessmentCohort studyAssociation of frailty with the incidence risk of cardiovascular disease and type 2 diabetes mellitus in long-term cancer survivors: a prospective cohort study
Cao X, Yang Z, Li X, Chen C, Hoogendijk E, Zhang J, Yao N, Ma L, Zhang Y, Zhu Y, Zhang X, Du Y, Wang X, Wu X, Gill T, Liu Z. Association of frailty with the incidence risk of cardiovascular disease and type 2 diabetes mellitus in long-term cancer survivors: a prospective cohort study. BMC Medicine 2023, 21: 74. PMID: 36829175, PMCID: PMC9951842, DOI: 10.1186/s12916-023-02774-1.Peer-Reviewed Original ResearchConceptsLong-term cancer survivorsType 2 diabetes mellitusCancer survivorsCardiovascular diseaseIncidence riskDiabetes mellitusFrailty IndicatorCox proportional hazards regression modelRisk of CVDProportional hazards regression modelsNon-frail participantsSerious healthcare burdenIncident cardiovascular diseaseMultivariable-adjusted modelsProspective cohort studyAssociation of frailtyPrimary care dataHazards regression modelsTime of recruitmentQuality of lifeLater comorbidityIncident T2DMCohort studyFrailty phenotypeFrailty index
2000
Role of Exercise Stress Testing and Safety Monitoring for Older Persons Starting an Exercise Program
Gill TM, DiPietro L, Krumholz HM. Role of Exercise Stress Testing and Safety Monitoring for Older Persons Starting an Exercise Program. JAMA 2000, 284: 342-349. PMID: 10891966, DOI: 10.1001/jama.284.3.342.Peer-Reviewed Original ResearchConceptsExercise stress testingAdverse cardiac eventsExercise programOlder personsCardiac eventsStress testingPhysical activityRoutine exercise stress testingSedentary older personsSymptomatic cardiovascular diseasePharmacological stress testingCurrent physician practiceRelative exercise intensityMajority of personsUnproven benefitPhysical functionCurrent guidelinesCardiovascular diseaseExercise intensityPhysician practicesSafety monitoringRiskExercisePersonsTesting