2019
Synaptic Connectivity and Cortical Maturation Are Promoted by the ω-3 Fatty Acid Docosahexaenoic Acid
Carbone BE, Abouleish M, Watters KE, Vogel S, Ribic A, Schroeder OH, Bader BM, Biederer T. Synaptic Connectivity and Cortical Maturation Are Promoted by the ω-3 Fatty Acid Docosahexaenoic Acid. Cerebral Cortex 2019, 30: 226-240. PMID: 31034037, DOI: 10.1093/cercor/bhz083.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedDendritesDocosahexaenoic AcidsMice, Inbred C57BLNeural PathwaysNeuronsSynapsesVisual AcuityVisual CortexConceptsVisual acuityDietary DHASynaptic connectivityFatty Acid Docosahexaenoic AcidVivo electrophysiological recordingsSize of synapsesEarly neuronal differentiationDose-dependent mannerFatty acid DHACortical maturationYoung miceAwake miceDendritic arborsCultured neuronsDHA's roleVisual cortexFunctional maturationPostsynaptic specializationsElectrophysiological recordingsCortical processingBrain developmentDocosahexaenoic acidAcid DHAPostnatal stagesNeuronal differentiationSynapse-Selective Control of Cortical Maturation and Plasticity by Parvalbumin-Autonomous Action of SynCAM 1
Ribic A, Crair MC, Biederer T. Synapse-Selective Control of Cortical Maturation and Plasticity by Parvalbumin-Autonomous Action of SynCAM 1. Cell Reports 2019, 26: 381-393.e6. PMID: 30625321, PMCID: PMC6345548, DOI: 10.1016/j.celrep.2018.12.069.Peer-Reviewed Original ResearchConceptsCortical plasticityCell adhesion molecule-1Critical periodJuvenile-like plasticityAdhesion molecule-1Primary visual cortexVisual critical periodThalamocortical inputsCortical maturationCircuit maturationV1 plasticityParvalbumin interneuronsFeedforward inhibitionSynaptic cell adhesion molecule 1Cell-autonomous mechanismsBrief lossCortical responsesSynaptic lociMolecule-1Visual cortexSynaptic factorsInterneuronsSpecific knockdownAdulthoodEyes
2016
Excitatory Synaptic Drive and Feedforward Inhibition in the Hippocampal CA3 Circuit Are Regulated by SynCAM 1
Park KA, Ribic A, Gaupp F, Coman D, Huang Y, Dulla CG, Hyder F, Biederer T. Excitatory Synaptic Drive and Feedforward Inhibition in the Hippocampal CA3 Circuit Are Regulated by SynCAM 1. Journal Of Neuroscience 2016, 36: 7464-7475. PMID: 27413156, PMCID: PMC4945666, DOI: 10.1523/jneurosci.0189-16.2016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCA3 Region, HippocampalCell Adhesion Molecule-1Cell Adhesion MoleculesConditioning, ClassicalFearFemaleGABA AntagonistsGene Expression RegulationImmunoglobulinsIn Vitro TechniquesMaleMemory DisordersMiceMice, Inbred C57BLMice, KnockoutNeural InhibitionNeural PathwaysParvalbuminsPyridazinesSynapsesSynaptic PotentialsTime FactorsConceptsDiffusion tensor imagingHippocampal CA3 areaKO miceMagnetic resonance imagingExcitatory inputsFeedforward inhibitionSynCAM 1Pyramidal neuronsNetwork excitabilityCA3 areaMossy fibersExcitatory mossy fiber inputBrain regionsTensor imagingHippocampal CA3 circuitsParvalbumin-positive interneuronsCA3 pyramidal neuronsPV-positive interneuronsExcitatory synaptic driveKnock-out (KO) miceDevelopment of synapsesDifferent neuronal populationsMossy fiber inputsDistinct brain regionsSynaptic imbalance
2015
Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains
de Arce K, Schrod N, Metzbower SWR, Allgeyer E, Kong G, Tang AH, Krupp AJ, Stein V, Liu X, Bewersdorf J, Blanpied TA, Lucić V, Biederer T. Topographic Mapping of the Synaptic Cleft into Adhesive Nanodomains. Neuron 2015, 88: 1165-1172. PMID: 26687224, PMCID: PMC4687029, DOI: 10.1016/j.neuron.2015.11.011.Peer-Reviewed Original ResearchConceptsSynaptic cell adhesion molecule 1Trans-synaptic complexesEphB2 receptor tyrosine kinaseReceptor tyrosine kinasesCryo-ETSynaptic cleftCryoelectron tomographyTyrosine kinaseMolecular insightsSynCAM 1Macromolecular organizationImmunoglobulin proteinCell adhesion molecule-1Immunoelectron microscopyAdhesion molecule-1Super-resolution imagingPostsynaptic densityDistinct density profilesDepression paradigmExcitatory synapsesPostsynaptic areaMolecule-1Cleft edgesSynapsesCleft
2014
Structural organization and function of mouse photoreceptor ribbon synapses involve the immunoglobulin protein synaptic cell adhesion molecule 1
Ribic A, Liu X, Crair MC, Biederer T. Structural organization and function of mouse photoreceptor ribbon synapses involve the immunoglobulin protein synaptic cell adhesion molecule 1. The Journal Of Comparative Neurology 2014, 522: 900-920. PMID: 23982969, PMCID: PMC3947154, DOI: 10.1002/cne.23452.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol OxidoreductasesAnalysis of VarianceAnimalsAnimals, NewbornCell Adhesion Molecule-1Cell Adhesion MoleculesCo-Repressor ProteinsDNA-Binding ProteinsElectroretinographyFemaleGene Expression Regulation, DevelopmentalImmunoglobulinsMaleMiceMice, Inbred C57BLMice, KnockoutMicroscopy, ImmunoelectronNerve Tissue ProteinsPhosphoproteinsReceptors, Metabotropic GlutamateRetinaRetinal Rod Photoreceptor CellsSynapsesVesicular Glutamate Transport Protein 1ConceptsCell adhesion molecule-1Adhesion molecule-1Ribbon synapsesKO retinasSynaptic cell adhesion molecule 1Molecule-1Mouse photoreceptor ribbon synapsesInner retinal layersPhotoreceptor ribbon synapsesRod visual pathwayEarly postnatal stagesPlexiform layerKO micePhotoreceptor synapsesSynaptic organizationExcitatory synapsesQuantitative ultrastructural analysisRetinal layersKnockout miceOuter nuclearVisual pathwaySynapse developmentElectroretinogram recordingsPostnatal stagesAdhesion molecules
2012
The Synaptic Adhesion Molecule SynCAM 1 Contributes to Cocaine Effects on Synapse Structure and Psychostimulant Behavior
Giza JI, Jung Y, Jeffrey RA, Neugebauer NM, Picciotto MR, Biederer T. The Synaptic Adhesion Molecule SynCAM 1 Contributes to Cocaine Effects on Synapse Structure and Psychostimulant Behavior. Neuropsychopharmacology 2012, 38: 628-638. PMID: 23169347, PMCID: PMC3572459, DOI: 10.1038/npp.2012.226.Peer-Reviewed Original ResearchConceptsNucleus accumbensDrugs of abuseSynCAM 1Cocaine effectsSynapse structureMushroom-type spinesExcitatory synapse numberMedium spiny neuronsAddiction-related behaviorsKO miceSpiny neuronsStubby spinesSynapse numberAdhesion molecule proteinsExcitatory synapsesCocaine administrationTrans-synaptic interactionsKnockout micePsychostimulant effectsNAc synapsesStructural remodelingTherapeutic interventionsSynaptic cleftPsychostimulant cocaineSynapse development