2024
Physics of bacterial chemotaxis
Moore J, Emonet T. Physics of bacterial chemotaxis. Current Biology 2024, 34: r972-r977. PMID: 39437738, DOI: 10.1016/j.cub.2024.05.054.Peer-Reviewed Original ResearchSignal integration and adaptive sensory diversity tuning in Escherichia coli chemotaxis
Moore J, Kamino K, Kottou R, Shimizu T, Emonet T. Signal integration and adaptive sensory diversity tuning in Escherichia coli chemotaxis. Cell Systems 2024, 15: 628-638.e8. PMID: 38981486, PMCID: PMC11307269, DOI: 10.1016/j.cels.2024.06.003.Peer-Reviewed Original ResearchEscherichia coli chemotaxisPopulation of E. coliMeasure kinase activityPhenotypic diversitySensory diversityDecreased diversityKinase activityDiverse phenotypesChemical signalsDiversitySingle cellsResponse to changesCellsSignalPhenotypePopulationChemotaxisSignal integrityLigandCompetitive ligandChemoattractantOlfactory cues and memories in animal navigation
Emonet T, Vergassola M. Olfactory cues and memories in animal navigation. Nature Reviews Physics 2024, 6: 215-216. PMID: 39166103, PMCID: PMC11331761, DOI: 10.1038/s42254-024-00710-7.Peer-Reviewed Original ResearchDirect measurement of dynamic attractant gradients reveals breakdown of the Patlak–Keller–Segel chemotaxis model
Phan T, Mattingly H, Vo L, Marvin J, Looger L, Emonet T. Direct measurement of dynamic attractant gradients reveals breakdown of the Patlak–Keller–Segel chemotaxis model. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2309251121. PMID: 38194458, PMCID: PMC10801886, DOI: 10.1073/pnas.2309251121.Peer-Reviewed Original Research
2023
Temporal novelty detection and multiple timescale integration drive Drosophila orientation dynamics in temporally diverse olfactory environments
Jayaram V, Sehdev A, Kadakia N, Brown E, Emonet T. Temporal novelty detection and multiple timescale integration drive Drosophila orientation dynamics in temporally diverse olfactory environments. PLOS Computational Biology 2023, 19: e1010606. PMID: 37167321, PMCID: PMC10205008, DOI: 10.1371/journal.pcbi.1010606.Peer-Reviewed Original ResearchOptimal inference of molecular interaction dynamics in FRET microscopy
Kamino K, Kadakia N, Avgidis F, Liu Z, Aoki K, Shimizu T, Emonet T. Optimal inference of molecular interaction dynamics in FRET microscopy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2211807120. PMID: 37014867, PMCID: PMC10104582, DOI: 10.1073/pnas.2211807120.Peer-Reviewed Original Research
2022
Odour motion sensing enhances navigation of complex plumes
Kadakia N, Demir M, Michaelis B, DeAngelis B, Reidenbach M, Clark D, Emonet T. Odour motion sensing enhances navigation of complex plumes. Nature 2022, 611: 754-761. PMID: 36352224, PMCID: PMC10039482, DOI: 10.1038/s41586-022-05423-4.Peer-Reviewed Original ResearchConceptsRobot navigationVirtual agentsEffective navigationMultiple featuresMultiple streamsNavigationUncertain environmentMotion sensingVirtual reality paradigmTemporal correlationDirectional informationNavigational decisionsInformationComplex plumesSensingAlgorithmSensory inputInputParadigmSearchEnvironmentStreamsGeneralityWhere is that smell coming from?
Brudner S, Emonet T. Where is that smell coming from? ELife 2022, 11: e82635. PMID: 36125436, PMCID: PMC9489204, DOI: 10.7554/elife.82635.Commentaries, Editorials and LettersCollective behavior and nongenetic inheritance allow bacterial populations to adapt to changing environments
Mattingly H, Emonet T. Collective behavior and nongenetic inheritance allow bacterial populations to adapt to changing environments. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2117377119. PMID: 35727978, PMCID: PMC9245662, DOI: 10.1073/pnas.2117377119.Peer-Reviewed Original ResearchConceptsNongenetic inheritanceCollective migrationPhenotype compositionIsogenic populationsDifferential lossSwimming phenotypeCell divisionBacterial populationsCell growthMultiple environmentsPhenotypePhenotypic compositionDifferent phenotypesInheritanceChemotactic bacteriaModel systemHigh inheritanceMigration speedDifferent environmentsNew environmentCollective behaviorMigrationPopulationGrowthDiversitySensing complementary temporal features of odor signals enhances navigation of diverse turbulent plumes
Jayaram V, Kadakia N, Emonet T. Sensing complementary temporal features of odor signals enhances navigation of diverse turbulent plumes. ELife 2022, 11: e72415. PMID: 35072625, PMCID: PMC8871351, DOI: 10.7554/elife.72415.Peer-Reviewed Original Research
2021
Escherichia coli chemotaxis is information limited
Mattingly H, Kamino K, Machta B, Emonet T. Escherichia coli chemotaxis is information limited. Nature Physics 2021, 17: 1426-1431. PMID: 35035514, PMCID: PMC8758097, DOI: 10.1038/s41567-021-01380-3.Peer-Reviewed Original ResearchNon-Genetic Diversity in Chemosensing and Chemotactic Behavior
Moore JP, Kamino K, Emonet T. Non-Genetic Diversity in Chemosensing and Chemotactic Behavior. International Journal Of Molecular Sciences 2021, 22: 6960. PMID: 34203411, PMCID: PMC8268644, DOI: 10.3390/ijms22136960.Peer-Reviewed Original ResearchA Primed Subpopulation of Bacteria Enables Rapid Expression of the Type 3 Secretion System in Pseudomonas aeruginosa
Lin CK, Lee DSW, McKeithen-Mead S, Emonet T, Kazmierczak B. A Primed Subpopulation of Bacteria Enables Rapid Expression of the Type 3 Secretion System in Pseudomonas aeruginosa. MBio 2021, 12: 10.1128/mbio.00831-21. PMID: 34154400, PMCID: PMC8262847, DOI: 10.1128/mbio.00831-21.Peer-Reviewed Original ResearchConceptsType 3 secretion systemSecretion systemT3SS expressionVirulence traitsSpecific virulence traitsHuman disease severityComplex nanomachinesT3SS genesP. aeruginosa cellsReproductive fitnessIsogenic cellsHeterogeneous expressionCell envelopeT3SS effectorsMotility organellesReservoir of cellsCritical virulence traitsGene expressionRegulatory mechanismsSubpopulation of cellsGram-negative pathogensFluorescent reportersDivision timeP. aeruginosaPseudomonas aeruginosa
2020
Adaptive tuning of cell sensory diversity without changes in gene expression
Kamino K, Keegstra JM, Long J, Emonet T, Shimizu TS. Adaptive tuning of cell sensory diversity without changes in gene expression. Science Advances 2020, 6: eabc1087. PMID: 33188019, PMCID: PMC7673753, DOI: 10.1126/sciadv.abc1087.Peer-Reviewed Original ResearchConceptsPhenotypic diversityGene expressionCell variationDiversity of phenotypesChemoreceptor TarPosttranslational modificationsAllosteric couplingEnvironmental cuesChemotaxis networkCovalent modificationEnvironmental changesDiversitySensory diversityCell populationsCellsExpressionSuch betsPhenotypeEscherichiaPopulationPrevious studiesModificationVariationSignalsChemoreceptorsWalking Drosophila navigate complex plumes using stochastic decisions biased by the timing of odor encounters
Demir M, Kadakia N, Anderson HD, Clark DA, Emonet T. Walking Drosophila navigate complex plumes using stochastic decisions biased by the timing of odor encounters. ELife 2020, 9: e57524. PMID: 33140723, PMCID: PMC7609052, DOI: 10.7554/elife.57524.Peer-Reviewed Original Research
2019
A rule from bacteria to balance growth and expansion
Mattingly H, Emonet T. A rule from bacteria to balance growth and expansion. Nature 2019, 575: 602-603. PMID: 31768038, DOI: 10.1038/d41586-019-03348-z.Peer-Reviewed Original ResearchFront-end Weber-Fechner gain control enhances the fidelity of combinatorial odor coding
Kadakia N, Emonet T. Front-end Weber-Fechner gain control enhances the fidelity of combinatorial odor coding. ELife 2019, 8: e45293. PMID: 31251174, PMCID: PMC6609331, DOI: 10.7554/elife.45293.Peer-Reviewed Original Research
2018
Erratum To: Non‐genetic diversity modulates population performance
Waite AJ, Frankel NW, Dufour YS, Johnston JF, Long J, Emonet T. Erratum To: Non‐genetic diversity modulates population performance. Molecular Systems Biology 2018, 14: msb178149. PMID: 29321185, PMCID: PMC5787705, DOI: 10.15252/msb.20178149.Peer-Reviewed Original Research
2017
Olfactory receptor neurons use gain control and complementary kinetics to encode intermittent odorant stimuli
Gorur-Shandilya S, Demir M, Long J, Clark DA, Emonet T. Olfactory receptor neurons use gain control and complementary kinetics to encode intermittent odorant stimuli. ELife 2017, 6: e27670. PMID: 28653907, PMCID: PMC5524537, DOI: 10.7554/elife.27670.Peer-Reviewed Original ResearchFeedback between motion and sensation provides nonlinear boost in run-and-tumble navigation
Long J, Zucker SW, Emonet T. Feedback between motion and sensation provides nonlinear boost in run-and-tumble navigation. PLOS Computational Biology 2017, 13: e1005429. PMID: 28264023, PMCID: PMC5358899, DOI: 10.1371/journal.pcbi.1005429.Peer-Reviewed Original ResearchConceptsNon-normal dynamicsRelevant parameter spaceFundamental nonlinearityParameter spaceInternal statesRandom reorientationDrift speedClassical drawbacksDynamics implicitStraight motionLarge transientsMotionAnalytical approachLarge fluctuationsDynamicsProbabilityNonlinearitySignal levelGradientFeedbackSpaceSpeedFluctuationsDirection