2024
Physics of bacterial chemotaxis
Moore J, Emonet T. Physics of bacterial chemotaxis. Current Biology 2024, 34: r972-r977. PMID: 39437738, DOI: 10.1016/j.cub.2024.05.054.Peer-Reviewed Original ResearchDirect measurement of dynamic attractant gradients reveals breakdown of the Patlak–Keller–Segel chemotaxis model
Phan T, Mattingly H, Vo L, Marvin J, Looger L, Emonet T. Direct measurement of dynamic attractant gradients reveals breakdown of the Patlak–Keller–Segel chemotaxis model. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2309251121. PMID: 38194458, PMCID: PMC10801886, DOI: 10.1073/pnas.2309251121.Peer-Reviewed Original Research
2022
Collective behavior and nongenetic inheritance allow bacterial populations to adapt to changing environments
Mattingly H, Emonet T. Collective behavior and nongenetic inheritance allow bacterial populations to adapt to changing environments. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2117377119. PMID: 35727978, PMCID: PMC9245662, DOI: 10.1073/pnas.2117377119.Peer-Reviewed Original ResearchConceptsNongenetic inheritanceCollective migrationPhenotype compositionIsogenic populationsDifferential lossSwimming phenotypeCell divisionBacterial populationsCell growthMultiple environmentsPhenotypePhenotypic compositionDifferent phenotypesInheritanceChemotactic bacteriaModel systemHigh inheritanceMigration speedDifferent environmentsNew environmentCollective behaviorMigrationPopulationGrowthDiversity
2021
Non-Genetic Diversity in Chemosensing and Chemotactic Behavior
Moore JP, Kamino K, Emonet T. Non-Genetic Diversity in Chemosensing and Chemotactic Behavior. International Journal Of Molecular Sciences 2021, 22: 6960. PMID: 34203411, PMCID: PMC8268644, DOI: 10.3390/ijms22136960.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBacteriaBacterial ProteinsChemotactic FactorsChemotaxisHumansSignal Transduction
2020
Adaptive tuning of cell sensory diversity without changes in gene expression
Kamino K, Keegstra JM, Long J, Emonet T, Shimizu TS. Adaptive tuning of cell sensory diversity without changes in gene expression. Science Advances 2020, 6: eabc1087. PMID: 33188019, PMCID: PMC7673753, DOI: 10.1126/sciadv.abc1087.Peer-Reviewed Original ResearchConceptsPhenotypic diversityGene expressionCell variationDiversity of phenotypesChemoreceptor TarPosttranslational modificationsAllosteric couplingEnvironmental cuesChemotaxis networkCovalent modificationEnvironmental changesDiversitySensory diversityCell populationsCellsExpressionSuch betsPhenotypeEscherichiaPopulationPrevious studiesModificationVariationSignalsChemoreceptors
2019
A rule from bacteria to balance growth and expansion
Mattingly H, Emonet T. A rule from bacteria to balance growth and expansion. Nature 2019, 575: 602-603. PMID: 31768038, DOI: 10.1038/d41586-019-03348-z.Peer-Reviewed Original Research
2014
Limits of Feedback Control in Bacterial Chemotaxis
Dufour YS, Fu X, Hernandez-Nunez L, Emonet T. Limits of Feedback Control in Bacterial Chemotaxis. PLOS Computational Biology 2014, 10: e1003694. PMID: 24967937, PMCID: PMC4072517, DOI: 10.1371/journal.pcbi.1003694.Peer-Reviewed Original ResearchConceptsFeedback controlIntegral feedback controlOperational regimesOptimal operational regimeComplex statisticsDrift velocityRobust performanceFuture inputsAdaptation rateProper information transferChemotactic driftAnalytical modelInput signalOptimal regimeActuatorsSteep gradientsProper couplingWide rangeChemotactic performanceRegimeBifurcationAdaptability of non-genetic diversity in bacterial chemotaxis
Frankel NW, Pontius W, Dufour YS, Long J, Hernandez-Nunez L, Emonet T. Adaptability of non-genetic diversity in bacterial chemotaxis. ELife 2014, 3: e03526. PMID: 25279698, PMCID: PMC4210811, DOI: 10.7554/elife.03526.Peer-Reviewed Original ResearchConceptsGene regulationNon-genetic diversityBacterial chemotaxis systemHeritable controlChemotaxis systemSelectable traitAdvantageous diversityEnvironmental variationBacterial chemotaxisEnvironmental variabilityClonal populationsDiverse environmentsDiversityE. coliProtein levelsMutationsDifferent environmentsRegulationForagingTraitsColiDiversificationBacteriaColonizationPopulation
2013
Adaptation Dynamics in Densely Clustered Chemoreceptors
Pontius W, Sneddon MW, Emonet T. Adaptation Dynamics in Densely Clustered Chemoreceptors. PLOS Computational Biology 2013, 9: e1003230. PMID: 24068908, PMCID: PMC3777915, DOI: 10.1371/journal.pcbi.1003230.Peer-Reviewed Original ResearchConceptsOrganisms senseChemotaxis pathwayTransmembrane receptorsNutrient gradientsReceptor methylationProtein abundanceReceptor substrateBacterial chemotaxisReceptor activityModification systemPathway constituentsEscherichia coliIndividual cellsEnvironmental stimuliFunctional robustnessExpression levelsMechanistic relationshipEnzymeModel systemEnzyme kineticsChemotaxis systemPrecise adaptationAdaptation dynamicsReceptor modificationModification kinetics
2011
Stochastic coordination of multiple actuators reduces latency and improves chemotactic response in bacteria
Sneddon MW, Pontius W, Emonet T. Stochastic coordination of multiple actuators reduces latency and improves chemotactic response in bacteria. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 109: 805-810. PMID: 22203971, PMCID: PMC3271881, DOI: 10.1073/pnas.1113706109.Peer-Reviewed Original ResearchThermal Robustness: Lessons from Bacterial Chemotaxis
Dufour YS, Sneddon MW, Emonet T. Thermal Robustness: Lessons from Bacterial Chemotaxis. Current Biology 2011, 21: r465-r468. PMID: 21683899, DOI: 10.1016/j.cub.2011.05.014.Peer-Reviewed Original Research
2010
Interdependence of behavioural variability and response to small stimuli in bacteria
Park H, Pontius W, Guet CC, Marko JF, Emonet T, Cluzel P. Interdependence of behavioural variability and response to small stimuli in bacteria. Nature 2010, 468: 819-823. PMID: 21076396, PMCID: PMC3230254, DOI: 10.1038/nature09551.Peer-Reviewed Original ResearchFine-Tuning of Chemotactic Response in E. coli Determined by High-Throughput Capillary Assay
Park H, Guet CC, Emonet T, Cluzel P. Fine-Tuning of Chemotactic Response in E. coli Determined by High-Throughput Capillary Assay. Current Microbiology 2010, 62: 764-769. PMID: 20972792, PMCID: PMC3230253, DOI: 10.1007/s00284-010-9778-z.Peer-Reviewed Original ResearchConceptsChemotactic responseWild-type levelsCapillary assayRobust chemotactic responseE. coliWild-type behaviorE. coli cellsPerfect adaptationDepletion of nutrientsColi cellsFusion proteinCellular growthChemotactic behaviorProteinIntracellular concentrationChemotactic proteinColiAssaysChemotaxisAdaptationSwimming bacteriaCheB.Effects of growthCheRGrowth
2005
AgentCell: a digital single-cell assay for bacterial chemotaxis
Emonet T, Macal CM, North MJ, Wickersham CE, Cluzel P. AgentCell: a digital single-cell assay for bacterial chemotaxis. Bioinformatics 2005, 21: 2714-2721. PMID: 15774553, DOI: 10.1093/bioinformatics/bti391.Peer-Reviewed Original ResearchConceptsBacterial chemotaxisSingle-cell biologySingle-cell assaysSingle-cell levelChemotaxis networkCellular behaviorBacterial populationsIntracellular processesIndividual cellsSingle cellsSwimming cellsMolecular interactionsChemotaxis assaysBiological systemsNew computational approachCellsComputational approachChemotaxisAssaysFlagellaBiologyBacterium
2004
From molecular noise to behavioural variability in a single bacterium
Korobkova E, Emonet T, Vilar JM, Shimizu TS, Cluzel P. From molecular noise to behavioural variability in a single bacterium. Nature 2004, 428: 574-578. PMID: 15058306, DOI: 10.1038/nature02404.Peer-Reviewed Original ResearchConceptsChemotaxis networkSingle-cell levelSignal transductionPopulation measurementsIntracellular networksMolecular noiseBehavioral variationMolecular eventsBiological complexityIndividual bacteriaNon-stimulated cellsEscherichia coliBehavioral variabilitySingle bacteriumTemporal fluctuationsStatistical fluctuationsTransductionSuch variabilityTemporal variationBacteriumColiGeneral understandingCertain propertiesBacteriaPathway