2000
Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk
Holford T, Zheng T, Mayne S, Zahm S, Tessari J, Boyle P. Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk. International Journal Of Epidemiology 2000, 29: 975-982. PMID: 11101537, DOI: 10.1093/ije/29.6.975.Peer-Reviewed Original ResearchConceptsBreast cancer riskCancer riskProtective effectBreast adipose tissue samplesYale-New Haven HospitalBreast-related surgeryAdipose tissue samplesStandardized questionnaireHealth concernCYP2B inducersAdverse effectsLogistic ridge regressionTissue samplesExposure levelsSignificant differencesMajor environmental health concernRiskEnvironmental health concernsPCB congenersDioxin-like congenersJoint effectsPatientsStatistical analysisSurgeryRegression
1978
Fibrocystic Breast Disease in Oral-Contraceptive Users — A Histopathological Evaluation of Epithelial Atypia
Livolsi V, Stadel B, Kelsey J, Holford T, White C. Fibrocystic Breast Disease in Oral-Contraceptive Users — A Histopathological Evaluation of Epithelial Atypia. New England Journal Of Medicine 1978, 299: 381-385. PMID: 566853, DOI: 10.1056/nejm197808242990803.Peer-Reviewed Original ResearchConceptsFibrocystic breast diseaseOral contraceptivesLong-term usersBreast cancerEpithelial atypiaFibrocystic diseaseBreast diseaseOral contraceptive usersLong-term usePremenopausal womenHistopathological evaluationHistologic standpointCystic diseasePremalignant formsEpidemiological studiesDiseaseContraceptivesAtypiaCancerWomenSignificant differencesNontakersIncidence