2024
Quantifying gaps in the tuberculosis care cascade in Brazil: A mathematical model study using national program data
Emani S, Alves K, Alves L, da Silva D, Oliveira P, Castro M, Cohen T, de Macedo Couto R, Sanchez M, Menzies N. Quantifying gaps in the tuberculosis care cascade in Brazil: A mathematical model study using national program data. PLOS Medicine 2024, 21: e1004361. PMID: 38512968, PMCID: PMC10994550, DOI: 10.1371/journal.pmed.1004361.Peer-Reviewed Original ResearchDisability-adjusted life yearsLoss to follow-upTreatment loss to follow-upCare cascadeHealth lossDelay to diagnosisTB diseaseTB diagnosisReduce delays to diagnosisHuman immunodeficiency virusContribution of social factorsTotal health system costsCare cascade outcomesTB care cascadeMortality Information SystemBurden of TB diseaseHealth system costsLifetime health outcomesNotifiable Diseases Information SystemBurden of diseaseIncident TB casesState of residenceNational program dataFollow-upHealth outcomes
2021
Lifetime burden of disease due to incident tuberculosis: a global reappraisal including post-tuberculosis sequelae
Menzies NA, Quaife M, Allwood BW, Byrne AL, Coussens AK, Harries AD, Marx FM, Meghji J, Pedrazzoli D, Salomon JA, Sweeney S, van Kampen SC, Wallis RS, Houben RMGJ, Cohen T. Lifetime burden of disease due to incident tuberculosis: a global reappraisal including post-tuberculosis sequelae. The Lancet Global Health 2021, 9: e1679-e1687. PMID: 34798027, PMCID: PMC8609280, DOI: 10.1016/s2214-109x(21)00367-3.Peer-Reviewed Original ResearchConceptsPost-tuberculosis sequelaeBurden estimatesTuberculosis diseaseDisease episodesIncident tuberculosisIncident tuberculosis casesIncident tuberculosis diseaseNon-fatal health lossOverall disease burdenPulmonary tuberculosis diseaseLifetime health outcomesDisease burden estimatesElevated mortality riskHigh incidence rateExtrapulmonary diseaseLung functionCase fatalityHIV statusLifetime burdenTuberculosis casesTotal DALYsDisease burdenIncidence rateHypothetical cohortTuberculosis survivors