2023
Development of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis
Gunasekera K, Marcy O, Muñoz J, Lopez-Varela E, Sekadde M, Franke M, Bonnet M, Ahmed S, Amanullah F, Anwar A, Augusto O, Aurilio R, Banu S, Batool I, Brands A, Cain K, Carratalá-Castro L, Caws M, Click E, Cranmer L, García-Basteiro A, Hesseling A, Huynh J, Kabir S, Lecca L, Mandalakas A, Mavhunga F, Myint A, Myo K, Nampijja D, Nicol M, Orikiriza P, Palmer M, Sant'Anna C, Siddiqui S, Smith J, Song R, Thuong Thuong N, Ung V, van der Zalm M, Verkuijl S, Viney K, Walters E, Warren J, Zar H, Marais B, Graham S, Debray T, Cohen T, Seddon J. Development of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis. The Lancet Child & Adolescent Health 2023, 7: 336-346. PMID: 36924781, PMCID: PMC10127218, DOI: 10.1016/s2352-4642(23)00004-4.Peer-Reviewed Original ResearchConceptsTreatment decision algorithmsPrimary health care settingsIndividual participant dataHigh tuberculosis incidencePulmonary tuberculosisManagement of tuberculosisHealth care centersComposite reference standardHealth care settingsClinical featuresTuberculosis incidenceClinical evaluationParticipant dataTreatment decisionsChest X-ray featuresPrimary health care centersFuture prospective evaluationTuberculosis-related mortalityEvidence-based algorithmChest X-rayVariable diagnostic performanceMultivariable prediction modelReference standardEvidence-based approachTuberculosis experts
2020
The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis
Martinez L, Cords O, Horsburgh C, Andrews J, Consortium P, Acuna-Villaorduna C, Ahuja S, Altet N, Augusto O, Baliashvili D, Basu S, Becerra M, Bonnet M, Boom W, Borgdorff M, Boulahbal F, Carvalho A, Cayla J, Chakhaia T, Chan P, Cohen T, Croda J, Datta S, del Corral H, Denholm J, Dietze R, Dobler C, Donkor S, Egere U, Ellner J, Espinal M, Evans C, Fang C, Fielding K, Fox G, García L, García-Basteiro A, Geis S, Graham S, Grandjean L, Hannoun D, Hatherill M, Hauri A, Hesseling A, Hill P, Huang L, Huerga H, Hussain R, Jarlsberg L, Jones-López E, Kato S, Kato-Maeda M, Kampmann B, Kirchner H, Kritski A, Lange C, Lee C, Lee L, Lee M, Lemos A, Lienhardt C, Ling D, Liu Q, Lo N, Long R, Lopez-Varela E, Lu P, Magee M, Malone L, Mandalakas A, Martinson N, Mazahir R, Murray M, Netto E, Otero L, Parsonnet J, Reingold A, Schaaf H, Seddon J, Sharma S, Singh J, Singh S, Sloot R, Sotgiu G, Stein C, Iqbal N, Triasih R, Trieu L, van der Loeff M, Van der Stuyft P, van Schalkwyk C, Vashishtha R, Verhagen L, Villalba J, Wang J, Whalen C, Yoshiyama T, Zar H, Zellweger J, Zhu L. The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis. The Lancet 2020, 395: 973-984. PMID: 32199484, PMCID: PMC7289654, DOI: 10.1016/s0140-6736(20)30166-5.Peer-Reviewed Original ResearchConceptsYears of agePreventive therapyIncident tuberculosisTuberculosis infectionHazard ratioTuberculosis casesMixed-effects Poisson regression modelsSystematic reviewFinal analysisClose exposureIncident tuberculosis casesRisk of tuberculosisDevelopment of tuberculosisEMBASE electronic databasesIndividual participant dataPositive resultsPoisson regression modelsWeb of ScienceMixed-effects logistic modelBCG vaccinationCohort studyBaseline visitPrevalent tuberculosisContact investigationProspective study