2012
Modeling the Dynamic Relationship Between HIV and the Risk of Drug-Resistant Tuberculosis
Sergeev R, Colijn C, Murray M, Cohen T. Modeling the Dynamic Relationship Between HIV and the Risk of Drug-Resistant Tuberculosis. Science Translational Medicine 2012, 4: 135ra67. PMID: 22623743, PMCID: PMC3387814, DOI: 10.1126/scitranslmed.3003815.Peer-Reviewed Original ResearchConceptsMultidrug-resistant TBDrug-resistant tuberculosisDrug-resistant TBHIV-seropositive individualsHIV statusTB patientsLatent Mycobacterium tuberculosis infectionIndividual HIV statusIncident HIV infectionMultidrug-resistant tuberculosisMycobacterium tuberculosis infectionEffects of HIVCross-sectional studyDrug-resistant formsRise of HIVIndividual-level associationsAcquisition of resistanceAverage CD4HIV infectionResistance-conferring mutationsTB controlTuberculosis infectionResistant tuberculosisTB drugsHIV epidemicOutcomes among tuberculosis patients with isoniazid resistance in Georgia, 2007-2009.
Gegia M, Cohen T, Kalandadze I, Vashakidze L, Furin J. Outcomes among tuberculosis patients with isoniazid resistance in Georgia, 2007-2009. The International Journal Of Tuberculosis And Lung Disease 2012, 16: 812-6. PMID: 22507372, PMCID: PMC3786434, DOI: 10.5588/ijtld.11.0637.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntitubercular AgentsChi-Square DistributionDrug Resistance, BacterialDrug Therapy, CombinationEthambutolFemaleGeorgia (Republic)HumansIsoniazidLogistic ModelsMaleMicrobial Sensitivity TestsMiddle AgedMultivariate AnalysisMycobacterium tuberculosisPredictive Value of TestsPyrazinamideRetrospective StudiesRifampinRisk AssessmentRisk FactorsSputumTime FactorsTreatment OutcomeTuberculosisConceptsPulmonary tuberculosisPrevious treatmentOutcomes of patientsPulmonary TB patientsSubset of patientsRetrospective record reviewForms of tuberculosisFirst-line drugsHigh TB ratesDrug-resistant formsLower ratesLow tuberculosisTB patientsTuberculosis patientsOptimal management strategyTreatment regimenRecord reviewTB ratesTreatment successTreatment outcomesCountry of GeorgiaPatientsIsoniazid resistanceTuberculosisDrug resistance
2011
Spontaneous Emergence of Multiple Drug Resistance in Tuberculosis before and during Therapy
Colijn C, Cohen T, Ganesh A, Murray M. Spontaneous Emergence of Multiple Drug Resistance in Tuberculosis before and during Therapy. PLOS ONE 2011, 6: e18327. PMID: 21479171, PMCID: PMC3068161, DOI: 10.1371/journal.pone.0018327.Peer-Reviewed Original ResearchConceptsMultiple drug resistanceDrug resistanceInitial treatment regimensTB control programsAnti-TB drugsDrug-resistant formsEmergence of resistanceFunctional monotherapyTreatment regimensCombination therapyTB strainsTuberculosis treatmentTherapy rangeM. tbTB bacilliMultidrug resistanceM. tuberculosisDifferent antibioticsTherapyTuberculosisInfected hostControl programsResistant formsTBMonotherapy