Naproxen or estradiol for bleeding and spotting with the levonorgestrel intrauterine system: a randomized controlled trial
Madden T, Proehl S, Allsworth J, Secura G, Peipert J. Naproxen or estradiol for bleeding and spotting with the levonorgestrel intrauterine system: a randomized controlled trial. American Journal Of Obstetrics And Gynecology 2011, 206: 129.e1-129.e8. PMID: 22055339, PMCID: PMC3268863, DOI: 10.1016/j.ajog.2011.09.021.Peer-Reviewed Original ResearchConceptsNaproxen groupIntrauterine systemLevonorgestrel-releasing intrauterine system useLevonorgestrel-releasing intrauterine systemAdministration of naproxenLevonorgestrel intrauterine systemIntrauterine system useOral naproxenEstradiol groupTreat analysisMultivariable analysisLowest quartileFrequent bleedingPlaceboEstradiol decreaseEstradiolTrialsWomenNaproxenDaysGroupBleedingQuartileAdministrationWeeks