Heat Shock Factor 1 Directly Regulates Postsynaptic Scaffolding PSD-95 in Aging and Huntington’s Disease and Influences Striatal Synaptic Density
Zarate N, Intihar T, Yu D, Sawyer J, Tsai W, Syed M, Carlson L, Gomez-Pastor R. Heat Shock Factor 1 Directly Regulates Postsynaptic Scaffolding PSD-95 in Aging and Huntington’s Disease and Influences Striatal Synaptic Density. International Journal Of Molecular Sciences 2021, 22: 13113. PMID: 34884918, PMCID: PMC8657899, DOI: 10.3390/ijms222313113.Peer-Reviewed Original ResearchConceptsHeat shock transcription factor 1PSD-95 levelsPSD-95 expressionPSD-95Huntington's diseaseShock transcription factor 1Synaptic protein levelsFactor 1Heat shock factor 1Direct regulatory relationshipIonotropic glutamate receptorsAge-dependent mannerShock factor 1Protein homeostasisWT miceAcute reductionSynaptic dysfunctionGene regulationTranscription factor 1Synaptic densityProtein essentialSynaptic punctaGlutamate receptorsBehavioral deficitsExcitatory synapses