2020
SGLT2 inhibitors in patients with cirrhosis and diabetes mellitus: A tertiary center cohort study and insights about a potential therapeutic target for portal hypertension
Saffo S, Garcia‐Tsao G, Taddei T. SGLT2 inhibitors in patients with cirrhosis and diabetes mellitus: A tertiary center cohort study and insights about a potential therapeutic target for portal hypertension. Journal Of Diabetes 2020, 13: 265-269. PMID: 33210815, DOI: 10.1111/1753-0407.13136.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBenzhydryl CompoundsCohort StudiesDiabetes Mellitus, Type 2FemaleGlucosidesGlycated HemoglobinHumansHypertension, PortalLiver CirrhosisMaleMiddle AgedOutcome Assessment, Health CarePolyuriaSodium-Glucose Transporter 2 InhibitorsTertiary Care CentersUrinary Tract InfectionsYoung AdultConceptsSGLT2 inhibitorsPortal hypertensionDiabetes mellitusSodium-glucose cotransporter 2 inhibitorsGlucose cotransporter 2 inhibitorsCenter cohort studyCotransporter 2 inhibitorsCohort of patientsPotential therapeutic targetFavorable pleiotropic effectsCohort studyRenal diseaseClinical trialsClinical dataTherapeutic targetPatientsCirrhosisHypertensionMellitusOngoing evaluationInhibitorsPleiotropic effectsCohortDiseaseTrials
2012
HCC Is promoted by bacterial translocation and TLR‐4 signaling: A new paradigm for chemoprevention and management
Toffanin S, Cornella H, Harrington A, Llovet J, Groszmann R, Iwakiri Y, Taddei T. HCC Is promoted by bacterial translocation and TLR‐4 signaling: A new paradigm for chemoprevention and management. Hepatology 2012, 56: 1998-2000. PMID: 23115011, DOI: 10.1002/hep.26080.Peer-Reviewed Original ResearchHepatocellular carcinomaToll-like receptorsIntestinal microbiotaLiver diseaseTranslocation of intestinal bacteriaResident liver cellsAdvanced liver diseaseChronically injured liverHepatocellular carcinoma preventionConsequence of chronic liver injuryTLR-4 signalingChronic liver diseaseChronic liver injuryHepatocellular carcinoma initiationHCC promotionPrevention of apoptosisBacterial translocationTLR-4Liver injuryHepatic inflammationTLR4 activationIncreased proliferationLong-term consequencesTherapeutic targetTLR4