2023
Association between statin exposure and short-term mortality in patients with high-grade acute-on-chronic liver failure
Chapin S, Kaplan D, Taddei T, Mahmud N. Association between statin exposure and short-term mortality in patients with high-grade acute-on-chronic liver failure. JHEP Reports 2023, 5: 100740. PMID: 37215188, PMCID: PMC10193237, DOI: 10.1016/j.jhepr.2023.100740.Peer-Reviewed Original ResearchChronic liver failureShort-term mortalityRetrospective cohort studyStatin exposureLiver failureStatin useCohort studyLogistic regression modelsLower oddsHigh short-term mortalityVeterans Health Administration patientsDose exposureMultivariable logistic regression modelClasses of medicationsFuture prospective studiesVeterans Health AdministrationDose-dependent reductionPotential beneficial effectsStatin therapyTerm mortalityAnalytic cohortRegression modelsProspective studyReduced oddsACLF
2022
Type of Infection Is Associated with Prognosis in Acute-on-Chronic Liver Failure: A National Veterans Health Administration Study
Mahmud N, Reddy KR, Taddei TH, Kaplan DE. Type of Infection Is Associated with Prognosis in Acute-on-Chronic Liver Failure: A National Veterans Health Administration Study. Digestive Diseases And Sciences 2022, 68: 1632-1640. PMID: 36083379, PMCID: PMC9995592, DOI: 10.1007/s10620-022-07680-9.Peer-Reviewed Original ResearchConceptsSpontaneous bacterial peritonitisChronic liver failureShort-term mortalityLiver failureHigh short-term mortalityACLF grade 3Retrospective cohort studyUrinary tract infectionMultivariable logistic regressionVeterans Health AdministrationType of infectionInverse probability treatmentLarge national databaseSource of infectionACLF gradeMSK infectionsCohort studyTract infectionsBacterial peritonitisMusculoskeletal infectionsFrequent precipitantInfectious sourceGrade 3Relative oddsHealth Administration
2020
Grade 1 Acute on Chronic Liver Failure Is a Predictor for Subsequent Grade 3 Failure
Mahmud N, Sundaram V, Kaplan DE, Taddei TH, Goldberg DS. Grade 1 Acute on Chronic Liver Failure Is a Predictor for Subsequent Grade 3 Failure. Hepatology 2020, 72: 230-239. PMID: 31677284, PMCID: PMC7195222, DOI: 10.1002/hep.31012.Peer-Reviewed Original ResearchConceptsChronic liver failureAcute decompensationLiver failureOrgan failureVeterans Health Administration databaseHigh short-term mortalityGrade 1 ACLFGrade 3 ACLFRetrospective cohort studyShort-term mortalityHealth Administration databaseACLF severityTransplant evaluationGastrointestinal bleedCohort studyCirculatory failureHepatic encephalopathyCox regressionACLFStratified analysisHigh riskLower riskPatientsPropensity scoreEuropean AssociationModels for acute on chronic liver failure development and mortality in a veterans affairs cohort
Xiao KY, Hubbard RA, Kaplan DE, Taddei TH, Goldberg DS, Mahmud N. Models for acute on chronic liver failure development and mortality in a veterans affairs cohort. Hepatology International 2020, 14: 587-596. PMID: 32519219, PMCID: PMC7656856, DOI: 10.1007/s12072-020-10060-y.Peer-Reviewed Original ResearchConceptsACLF mortalityCompensated cirrhosisChronic liver failure developmentEnd-stage liver diseaseHigh short-term mortalityLarge North American cohortDevelopment of ACLFVeterans Affairs cohortAsian Pacific AssociationChronic liver failureEscalation of careNovel risk prediction modelShort-term mortalityMultivariable logistic regressionNorth American cohortRisk prediction modelGood discriminationACLF developmentACLF patientsACLF scoreLiver (APASL) definitionsMELD-sodiumTransplant evaluationRisk patientsCirrhosis patients
2019
Risk prediction scores for acute on chronic liver failure development and mortality
Mahmud N, Hubbard RA, Kaplan DE, Taddei TH, Goldberg DS. Risk prediction scores for acute on chronic liver failure development and mortality. Liver International 2019, 40: 1159-1167. PMID: 31840390, PMCID: PMC7371261, DOI: 10.1111/liv.14328.Peer-Reviewed Original ResearchConceptsShort-term mortalityRisk prediction scoreACLF mortalityACLF scoreLiver diseaseChronic Liver Failure Consortium ACLF scoreChronic liver failure developmentCLIF-C ACLF scoreStable chronic liver diseaseVeterans Health Administration databaseEnd-stage liver diseaseHigh short-term mortalityEarly transplant referralChronic liver failureRetrospective cohort studyEscalation of careChronic liver diseaseUnited States cohortMultivariable logistic regressionNovel risk prediction scorePrediction scoreHealth Administration databaseGood discriminationACLF criteriaIncident cirrhosisIncidence and Mortality of Acute‐on‐Chronic Liver Failure Using Two Definitions in Patients with Compensated Cirrhosis
Mahmud N, Kaplan DE, Taddei TH, Goldberg DS. Incidence and Mortality of Acute‐on‐Chronic Liver Failure Using Two Definitions in Patients with Compensated Cirrhosis. Hepatology 2019, 69: 2150-2163. PMID: 30615211, PMCID: PMC6461492, DOI: 10.1002/hep.30494.Peer-Reviewed Original ResearchConceptsHigh short-term mortalityChronic liver failureShort-term mortalityIncidence rateCompensated cirrhosisLiver failureLiver diseaseLiver functionNonalcoholic fatty liver diseaseMedian bilirubin levelRetrospective cohort studyChronic liver diseaseFatty liver diseaseMajority of patientsVeterans Health AdministrationACLF criteriaACLF incidenceAPASL criteriaHepatitis CCohort studyBilirubin levelsPatient groupAcute insultACLFCirrhosis