2013
Cornichons Control ER Export of AMPA Receptors to Regulate Synaptic Excitability
Brockie PJ, Jensen M, Mellem JE, Jensen E, Yamasaki T, Wang R, Maxfield D, Thacker C, Hoerndli F, Dunn PJ, Tomita S, Madsen DM, Maricq AV. Cornichons Control ER Export of AMPA Receptors to Regulate Synaptic Excitability. Neuron 2013, 80: 129-142. PMID: 24094107, PMCID: PMC3795439, DOI: 10.1016/j.neuron.2013.07.028.Peer-Reviewed Original ResearchConceptsGlutamatergic synaptic transmissionGlutamate-gated currentsNervous system functionIonotropic glutamate receptorsC. elegansER exportSynaptic excitabilityCargo adaptorsTransgenic wormsGenetic approachesOpposite phenotypeCornichon ProteinsGlutamate receptorsSynaptic transmissionAgonist AMPAHeterologous cellsAMPA receptorsCentral synapsesAMPAR numberSynaptic communicationReconstitution studies
2011
PDZ binding of TARPγ-8 controls synaptic transmission but not synaptic plasticity
Sumioka A, Brown TE, Kato AS, Bredt DS, Kauer JA, Tomita S. PDZ binding of TARPγ-8 controls synaptic transmission but not synaptic plasticity. Nature Neuroscience 2011, 14: 1410-1412. PMID: 22002768, PMCID: PMC3206644, DOI: 10.1038/nn.2952.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnimalsAnimals, NewbornBiophysicsCalcium ChannelsDisks Large Homolog 4 ProteinElectric StimulationGene Expression Regulation, DevelopmentalGuanylate KinasesHippocampusIn Vitro TechniquesLong-Term PotentiationMembrane ProteinsMiceMice, TransgenicModels, BiologicalMutationNeuronal PlasticityPatch-Clamp TechniquesPDZ DomainsSynaptic TransmissionSynaptophysinSynaptosomesDistinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1
Straub C, Hunt DL, Yamasaki M, Kim KS, Watanabe M, Castillo PE, Tomita S. Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1. Nature Neuroscience 2011, 14: 866-873. PMID: 21623363, PMCID: PMC3125417, DOI: 10.1038/nn.2837.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBiophysical PhenomenaBiophysicsCA1 Region, HippocampalCell Line, TransformedCerebellumDisks Large Homolog 4 ProteinDizocilpine MaleateDose-Response Relationship, DrugDrug InteractionsElectric StimulationExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsGene Expression RegulationGreen Fluorescent ProteinsGuanylate KinasesHumansImmunoprecipitationIn Vitro TechniquesIntracellular Signaling Peptides and ProteinsKainic AcidLDL-Receptor Related ProteinsLipoproteins, LDLMembrane PotentialsMembrane ProteinsMiceMice, KnockoutNeuronsPatch-Clamp TechniquesPresynaptic TerminalsProtein BindingProtein SubunitsReceptors, Kainic AcidReceptors, N-Methyl-D-AspartateSynaptophysinTransfectionTritium
2010
Hippocampal AMPA Receptor Gating Controlled by Both TARP and Cornichon Proteins
Kato AS, Gill MB, Ho MT, Yu H, Tu Y, Siuda ER, Wang H, Qian YW, Nisenbaum ES, Tomita S, Bredt DS. Hippocampal AMPA Receptor Gating Controlled by Both TARP and Cornichon Proteins. Neuron 2010, 68: 1082-1096. PMID: 21172611, PMCID: PMC3034222, DOI: 10.1016/j.neuron.2010.11.026.Peer-Reviewed Original ResearchConceptsTransmembrane AMPA receptor regulatory proteinsAMPA receptor complexesHippocampal neuronsAMPA receptorsCornichon ProteinsReceptor complexAMPA receptor traffickingReceptor regulatory proteinsGlutamate applicationKnockout miceTARP γReceptor pharmacologyCNIH-2Electrophysiological propertiesPostsynaptic densityAMPA receptor gatingSubunit combinationsProtein levelsResensitizationReceptor traffickingNeuronsPharmacologyReceptorsReceptor gatingRecombinant systemsTARP Phosphorylation Regulates Synaptic AMPA Receptors through Lipid Bilayers
Sumioka A, Yan D, Tomita S. TARP Phosphorylation Regulates Synaptic AMPA Receptors through Lipid Bilayers. Neuron 2010, 66: 755-767. PMID: 20547132, PMCID: PMC2887694, DOI: 10.1016/j.neuron.2010.04.035.Peer-Reviewed Original ResearchConceptsAMPA receptor activityTransmembrane AMPA receptor regulatory proteinsReceptor activityGlutamate receptorsSynaptic transmissionAMPA receptorsAMPA receptor-mediated synaptic transmissionPredominant excitatory neurotransmitter receptorsReceptor-mediated synaptic transmissionAMPA-type glutamate receptorsSynaptic AMPA receptorsFast synaptic transmissionIonotropic glutamate receptorsExcitatory neurotransmitter receptorsReceptor regulatory proteinsNeuronal activityNeurotransmitter receptorsPSD-95Synaptic strengthNeural circuitsReceptorsPhosphorylation-dependent mannerStargazinSynapsesTarp phosphorylation
2009
A Transmembrane Accessory Subunit that Modulates Kainate-Type Glutamate Receptors
Zhang W, St-Gelais F, Grabner CP, Trinidad JC, Sumioka A, Morimoto-Tomita M, Kim KS, Straub C, Burlingame AL, Howe JR, Tomita S. A Transmembrane Accessory Subunit that Modulates Kainate-Type Glutamate Receptors. Neuron 2009, 61: 385-396. PMID: 19217376, PMCID: PMC2803770, DOI: 10.1016/j.neuron.2008.12.014.Peer-Reviewed Original ResearchConceptsKainate-type glutamate receptorsGlutamate receptorsIonotropic glutamate receptorsKainate receptorsSynaptic transmissionSurface expressionNative kainate receptorsFast synaptic transmissionKainate receptor subunitsBrain-specific proteinsExcitatory transmissionNMDA receptorsAMPA receptorsReceptor subunitsReceptorsProtein levelsNETO2Auxiliary subunitsTARP auxiliary subunitsBrainVertebrate brainKainate receptor GluR6Proteomic screenMajor roleMEPSCs
2001
PDZ Protein Interactions Regulating Glutamate Receptor Function and Plasticity
Tomita S, Nicoll R, Bredt D. PDZ Protein Interactions Regulating Glutamate Receptor Function and Plasticity. Journal Of Cell Biology 2001, 153: f19-f24. PMID: 11381098, PMCID: PMC2174328, DOI: 10.1083/jcb.153.5.f19.Peer-Reviewed Original Research