2023
Nucleolar structure connects with global nuclear organization.
Wang C, Ma H, Baserga S, Pederson T, Huang S. Nucleolar structure connects with global nuclear organization. Molecular Biology Of The Cell 2023, 34: ar114. PMID: 37610836, PMCID: PMC10846622, DOI: 10.1091/mbc.e23-02-0062.Peer-Reviewed Original ResearchConceptsNucleolar structureGenomic lociNuclear domainsSpecific genomic lociGlobal nuclear organizationRNA processing factorsRNA polymerase ICajal bodiesNuclear organizationRibosome synthesisNuclear bodiesKnockdown cellsPerinucleolar compartmentPolymerase IIntranuclear locationHeLa cellsNucleolar segregationSpatial organizationNucleoliLociUtp4CellsRPA194SegregationCompositional changes
2015
Determinants of mammalian nucleolar architecture
Farley KI, Surovtseva Y, Merkel J, Baserga SJ. Determinants of mammalian nucleolar architecture. Chromosoma 2015, 124: 323-331. PMID: 25670395, PMCID: PMC4534358, DOI: 10.1007/s00412-015-0507-z.Peer-Reviewed Original ResearchConceptsNucleolar formationNucleolar architectureNucleolar structureNucleolar organizer regionsProduction of ribosomesRibosome biogenesisFunctional nucleoliHuman nucleoliCell divisionOrganizer regionsNucleoliEssential machineFunction manifestBiogenesisIntricate relationshipMinimal requirementsCellsRibosomesOrganellesProteinFunctionFormationDivisionDeterminants