2018
Semiquantitative Analysis of Dopamine Transporter Scans in Patients With Parkinson Disease
Tinaz S, Chow C, Kuo PH, Krupinski EA, Blumenfeld H, Louis ED, Zubal G. Semiquantitative Analysis of Dopamine Transporter Scans in Patients With Parkinson Disease. Clinical Nuclear Medicine 2018, 43: e1-e7. PMID: 29112012, PMCID: PMC7257254, DOI: 10.1097/rlu.0000000000001885.Peer-Reviewed Original ResearchMeSH KeywordsAdultCase-Control StudiesCohort StudiesDopamine Plasma Membrane Transport ProteinsFemaleHumansImage Processing, Computer-AssistedMaleParkinson DiseaseROC CurveTomography, Emission-Computed, Single-PhotonConceptsStriatal binding ratiosDAT scanParkinson's diseaseParkinson's Progression Markers Initiative (PPMI) databaseDopamine transporter imagingDopamine transporter scanAdjunct diagnostic toolBinding ratioOutpatient cohortPPMI cohortTransporter imagingParkinsonian disordersMotor severityHealthy controlsClinical measuresStriatal regionsVisual readsTest cohortTest patientsSignificant negative correlationPatientsPPMI databaseDiagnostic aidCohortTraining group
2015
Role of the right dorsal anterior insula in the urge to tic in tourette syndrome
Tinaz S, Malone P, Hallett M, Horovitz SG. Role of the right dorsal anterior insula in the urge to tic in tourette syndrome. Movement Disorders 2015, 30: 1190-1197. PMID: 25855089, PMCID: PMC5088605, DOI: 10.1002/mds.26230.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCerebral CortexDominance, CerebralFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedOxygenRestTicsTourette SyndromeYoung AdultConceptsRight dorsal anterior insulaDorsal anterior insulaTourette syndromeAnterior insulaFunctional connectivityBilateral supplementary motor areaResting-state functional magnetic resonance imagingAdult Tourette patientsSupplementary motor areaDorsal-anterior partFunctional magnetic resonance imagingMagnetic resonance imagingCortico-striatoTourette patientsUrge suppressionHealthy subjectsMotor areaThalamic regionsTic severityPremonitory urgesPatientsSyndromeUrge severityResonance imagingTic generation
2010
Focal cortical and subcortical atrophy in early Parkinson's disease
Tinaz S, Courtney MG, Stern CE. Focal cortical and subcortical atrophy in early Parkinson's disease. Movement Disorders 2010, 26: 436-441. PMID: 21462259, PMCID: PMC4502575, DOI: 10.1002/mds.23453.Peer-Reviewed Original ResearchConceptsParkinson's disease patientsDisease patientsParkinson's diseaseDisease groupEarly-stage Parkinson's disease patientsSubstantia nigra pars compactaAnxiety state scoresFocal cortical thinningEarly Parkinson's diseaseParkinson's disease groupCortical thickness changesManifest Parkinson's diseaseStriatal volume lossSubcortical structural changesOccipito-parietal areasHealthy control participantsLimbic cortexPars compactaSubcortical atrophyCortical thinningVentrolateral prefrontal cortexCortical thicknessSubcortical volumesControl groupAlzheimer's disease