2018
Semiquantitative Analysis of Dopamine Transporter Scans in Patients With Parkinson Disease
Tinaz S, Chow C, Kuo PH, Krupinski EA, Blumenfeld H, Louis ED, Zubal G. Semiquantitative Analysis of Dopamine Transporter Scans in Patients With Parkinson Disease. Clinical Nuclear Medicine 2018, 43: e1-e7. PMID: 29112012, PMCID: PMC7257254, DOI: 10.1097/rlu.0000000000001885.Peer-Reviewed Original ResearchConceptsStriatal binding ratiosDAT scanParkinson's diseaseParkinson's Progression Markers Initiative (PPMI) databaseDopamine transporter imagingDopamine transporter scanAdjunct diagnostic toolBinding ratioOutpatient cohortPPMI cohortTransporter imagingParkinsonian disordersMotor severityHealthy controlsClinical measuresStriatal regionsVisual readsTest cohortTest patientsSignificant negative correlationPatientsPPMI databaseDiagnostic aidCohortTraining group
2016
Changes in functional organization and white matter integrity in the connectome in Parkinson's disease
Tinaz S, Lauro PM, Ghosh P, Lungu C, Horovitz SG. Changes in functional organization and white matter integrity in the connectome in Parkinson's disease. NeuroImage Clinical 2016, 13: 395-404. PMID: 28116232, PMCID: PMC5226806, DOI: 10.1016/j.nicl.2016.12.019.Peer-Reviewed Original ResearchConceptsParkinson's diseaseWhite matter integrityPD patientsPD groupWhite matter connectivity changesResting-state functional MRINon-demented PD patientsEarly disease stagesCortico-striatal circuitsWhite matter connectivityDopaminergic medicationDorsal attention networkDisease stageFunctional organizationSensorimotor networkWhole-brain connectomeFunctional modular organizationWhite matterFunctional MRIConnectivity changesDiseasePatientsDiffusion tensorDefault modeBrain connectome
2015
Role of the right dorsal anterior insula in the urge to tic in tourette syndrome
Tinaz S, Malone P, Hallett M, Horovitz SG. Role of the right dorsal anterior insula in the urge to tic in tourette syndrome. Movement Disorders 2015, 30: 1190-1197. PMID: 25855089, PMCID: PMC5088605, DOI: 10.1002/mds.26230.Peer-Reviewed Original ResearchConceptsRight dorsal anterior insulaDorsal anterior insulaTourette syndromeAnterior insulaFunctional connectivityBilateral supplementary motor areaResting-state functional magnetic resonance imagingAdult Tourette patientsSupplementary motor areaDorsal-anterior partFunctional magnetic resonance imagingMagnetic resonance imagingCortico-striatoTourette patientsUrge suppressionHealthy subjectsMotor areaThalamic regionsTic severityPremonitory urgesPatientsSyndromeUrge severityResonance imagingTic generationDeficits in task-set maintenance and execution networks in Parkinson’s disease
Tinaz S, Lauro P, Hallett M, Horovitz SG. Deficits in task-set maintenance and execution networks in Parkinson’s disease. Brain Structure And Function 2015, 221: 1413-1425. PMID: 25567420, PMCID: PMC5565229, DOI: 10.1007/s00429-014-0981-8.Peer-Reviewed Original Research
2014
Role of the sensorimotor cortex in tourette syndrome using multimodal imaging
Tinaz S, Belluscio BA, Malone P, van der Veen J, Hallett M, Horovitz SG. Role of the sensorimotor cortex in tourette syndrome using multimodal imaging. Human Brain Mapping 2014, 35: 5834-5846. PMID: 25044024, PMCID: PMC4776755, DOI: 10.1002/hbm.22588.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidSensorimotor cortexTourette syndromeFunctional magnetic resonance imagingBeta band powerH-Magnetic Resonance SpectroscopyState functional connectivity patternsMagnetic resonance imagingFunctional connectivity patternsMost patientsProcessing disturbancesSensory processing disturbanceVocal ticsLimbic inputsMotor phenomenaPremonitory sensationsPatientsResonance imagingTic generationNeuropsychiatric disordersAnterior insulaBand powerBeta oscillationsBeta activitySyndrome
2010
Focal cortical and subcortical atrophy in early Parkinson's disease
Tinaz S, Courtney MG, Stern CE. Focal cortical and subcortical atrophy in early Parkinson's disease. Movement Disorders 2010, 26: 436-441. PMID: 21462259, PMCID: PMC4502575, DOI: 10.1002/mds.23453.Peer-Reviewed Original ResearchConceptsParkinson's disease patientsDisease patientsParkinson's diseaseDisease groupEarly-stage Parkinson's disease patientsSubstantia nigra pars compactaAnxiety state scoresFocal cortical thinningEarly Parkinson's diseaseParkinson's disease groupCortical thickness changesManifest Parkinson's diseaseStriatal volume lossSubcortical structural changesOccipito-parietal areasHealthy control participantsLimbic cortexPars compactaSubcortical atrophyCortical thinningVentrolateral prefrontal cortexCortical thicknessSubcortical volumesControl groupAlzheimer's disease