2015
Role of the right dorsal anterior insula in the urge to tic in tourette syndrome
Tinaz S, Malone P, Hallett M, Horovitz SG. Role of the right dorsal anterior insula in the urge to tic in tourette syndrome. Movement Disorders 2015, 30: 1190-1197. PMID: 25855089, PMCID: PMC5088605, DOI: 10.1002/mds.26230.Peer-Reviewed Original ResearchConceptsRight dorsal anterior insulaDorsal anterior insulaTourette syndromeAnterior insulaFunctional connectivityBilateral supplementary motor areaResting-state functional magnetic resonance imagingAdult Tourette patientsSupplementary motor areaDorsal-anterior partFunctional magnetic resonance imagingMagnetic resonance imagingCortico-striatoTourette patientsUrge suppressionHealthy subjectsMotor areaThalamic regionsTic severityPremonitory urgesPatientsSyndromeUrge severityResonance imagingTic generation
2014
Role of the sensorimotor cortex in tourette syndrome using multimodal imaging
Tinaz S, Belluscio BA, Malone P, van der Veen J, Hallett M, Horovitz SG. Role of the sensorimotor cortex in tourette syndrome using multimodal imaging. Human Brain Mapping 2014, 35: 5834-5846. PMID: 25044024, PMCID: PMC4776755, DOI: 10.1002/hbm.22588.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidSensorimotor cortexTourette syndromeFunctional magnetic resonance imagingBeta band powerH-Magnetic Resonance SpectroscopyState functional connectivity patternsMagnetic resonance imagingFunctional connectivity patternsMost patientsProcessing disturbancesSensory processing disturbanceVocal ticsLimbic inputsMotor phenomenaPremonitory sensationsPatientsResonance imagingTic generationNeuropsychiatric disordersAnterior insulaBand powerBeta oscillationsBeta activitySyndrome