2024
Clinical correlates of dopamine transporter availability in cross-sectional and longitudinal studies with [18F]FE-PE2I PET: independent validation with new insights
Honhar P, Sadabad F, Tinaz S, Gallezot J, Dias M, Naganawa M, Yang Y, Henry S, Hillmer A, Gao H, Najafzadeh S, Comley R, Nabulsi N, Huang Y, Finnema S, Carson R, Matuskey D. Clinical correlates of dopamine transporter availability in cross-sectional and longitudinal studies with [18F]FE-PE2I PET: independent validation with new insights. Brain Communications 2024, 6: fcae345. PMID: 39429243, PMCID: PMC11487911, DOI: 10.1093/braincomms/fcae345.Peer-Reviewed Original ResearchDAT availabilityMotor severitySubstantia nigraDopamine transporter availabilityClinical trials of Parkinson's diseaseParkinson's diseaseLongitudinal studyTracking longitudinal changesClinical correlatesVentral striatumTransporter availabilityNigrostriatal regionParkinson's disease patientsPutamenMotor severity scoresAssociated with increasesSubstantiaDATLongitudinal changesTremor scoreNegative associationNigraSubstantia nigra of Parkinson's disease patientsTremor severityPET biomarkers
2023
Objective response to ethanol in essential tremor: results from a standardized ethanol challenge study
McGurrin P, Norato G, Thompson‐Westra J, McCrossin G, Lines E, Lungu C, Pandey S, Tinaz S, Voller B, Ramchandani V, Hallett M, Haubenberger D. Objective response to ethanol in essential tremor: results from a standardized ethanol challenge study. Annals Of Clinical And Translational Neurology 2023, 11: 156-168. PMID: 38087917, PMCID: PMC10791018, DOI: 10.1002/acn3.51943.Peer-Reviewed Original ResearchObjective responseEthanol administrationEssential tremorSingle-dose challengeThird of patientsPrior ethanol exposureTremor frequencyBreath alcohol levelsMechanism of actionResponder rateEthanol doseBreath alcohol concentrationAcute ethanolEthanol exposureResponder statusAlcohol concentration levelsET patientsChallenge studiesPatientsTremor reductionAlcohol levelsOral ethanolResponse definitionsSecondary analysisTremor severity