2023
Objective response to ethanol in essential tremor: results from a standardized ethanol challenge study
McGurrin P, Norato G, Thompson‐Westra J, McCrossin G, Lines E, Lungu C, Pandey S, Tinaz S, Voller B, Ramchandani V, Hallett M, Haubenberger D. Objective response to ethanol in essential tremor: results from a standardized ethanol challenge study. Annals Of Clinical And Translational Neurology 2023, 11: 156-168. PMID: 38087917, PMCID: PMC10791018, DOI: 10.1002/acn3.51943.Peer-Reviewed Original ResearchObjective responseEthanol administrationEssential tremorSingle-dose challengeThird of patientsPrior ethanol exposureTremor frequencyBreath alcohol levelsMechanism of actionResponder rateEthanol doseBreath alcohol concentrationAcute ethanolEthanol exposureResponder statusAlcohol concentration levelsET patientsChallenge studiesPatientsTremor reductionAlcohol levelsOral ethanolResponse definitionsSecondary analysisTremor severity
2018
A comparison of resting-state functional magnetic resonance imaging between Neurological and Liver-only affected Wilson’s Disease patients (P4.014)
Nalamada K, Tinaz S, Arora J, Vives-Rodriguez A, Constable T, Schilsky M, Robakis D. A comparison of resting-state functional magnetic resonance imaging between Neurological and Liver-only affected Wilson’s Disease patients (P4.014). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p4.014.Peer-Reviewed Original ResearchFunctional Magnetic Resonance Imaging-Based Neurofeedback Training in Patients with Parkinson’s Disease (P3.075)
Tinaz S, Nalamada K, Sezgin M, Vives-Rodriguez A, Para K, Scheinost D, Louis E, Hampson M. Functional Magnetic Resonance Imaging-Based Neurofeedback Training in Patients with Parkinson’s Disease (P3.075). Neurology 2018, 90 DOI: 10.1212/wnl.90.15_supplement.p3.075.Peer-Reviewed Original ResearchSemiquantitative Analysis of Dopamine Transporter Scans in Patients With Parkinson Disease
Tinaz S, Chow C, Kuo PH, Krupinski EA, Blumenfeld H, Louis ED, Zubal G. Semiquantitative Analysis of Dopamine Transporter Scans in Patients With Parkinson Disease. Clinical Nuclear Medicine 2018, 43: e1-e7. PMID: 29112012, PMCID: PMC7257254, DOI: 10.1097/rlu.0000000000001885.Peer-Reviewed Original ResearchConceptsStriatal binding ratiosDAT scanParkinson's diseaseParkinson's Progression Markers Initiative (PPMI) databaseDopamine transporter imagingDopamine transporter scanAdjunct diagnostic toolBinding ratioOutpatient cohortPPMI cohortTransporter imagingParkinsonian disordersMotor severityHealthy controlsClinical measuresStriatal regionsVisual readsTest cohortTest patientsSignificant negative correlationPatientsPPMI databaseDiagnostic aidCohortTraining group
2016
Changes in functional organization and white matter integrity in the connectome in Parkinson's disease
Tinaz S, Lauro PM, Ghosh P, Lungu C, Horovitz SG. Changes in functional organization and white matter integrity in the connectome in Parkinson's disease. NeuroImage Clinical 2016, 13: 395-404. PMID: 28116232, PMCID: PMC5226806, DOI: 10.1016/j.nicl.2016.12.019.Peer-Reviewed Original ResearchConceptsParkinson's diseaseWhite matter integrityPD patientsPD groupWhite matter connectivity changesResting-state functional MRINon-demented PD patientsEarly disease stagesCortico-striatal circuitsWhite matter connectivityDopaminergic medicationDorsal attention networkDisease stageFunctional organizationSensorimotor networkWhole-brain connectomeFunctional modular organizationWhite matterFunctional MRIConnectivity changesDiseasePatientsDiffusion tensorDefault modeBrain connectomeSequence Effect in Parkinson’s Disease Is Related to Motor Energetic Cost
Tinaz S, Pillai AS, Hallett M. Sequence Effect in Parkinson’s Disease Is Related to Motor Energetic Cost. Frontiers In Neurology 2016, 7: 83. PMID: 27252678, PMCID: PMC4877367, DOI: 10.3389/fneur.2016.00083.Peer-Reviewed Original ResearchParkinson's diseaseDopaminergic treatmentIsometric motor tasksVisual feedbackMotor symptomsPD patientsExternal cueingMedication statusPatientsMotor outputRepetitive movementsMajor causeMotor tasksDiseaseHighest motor costMotor plansBradykinesiaMotor controlMotor vigorMotivational cuesRapid decrementTreatmentMorbidityMixed resultsControl
2015
Role of the right dorsal anterior insula in the urge to tic in tourette syndrome
Tinaz S, Malone P, Hallett M, Horovitz SG. Role of the right dorsal anterior insula in the urge to tic in tourette syndrome. Movement Disorders 2015, 30: 1190-1197. PMID: 25855089, PMCID: PMC5088605, DOI: 10.1002/mds.26230.Peer-Reviewed Original ResearchConceptsRight dorsal anterior insulaDorsal anterior insulaTourette syndromeAnterior insulaFunctional connectivityBilateral supplementary motor areaResting-state functional magnetic resonance imagingAdult Tourette patientsSupplementary motor areaDorsal-anterior partFunctional magnetic resonance imagingMagnetic resonance imagingCortico-striatoTourette patientsUrge suppressionHealthy subjectsMotor areaThalamic regionsTic severityPremonitory urgesPatientsSyndromeUrge severityResonance imagingTic generation
2014
Role of the sensorimotor cortex in tourette syndrome using multimodal imaging
Tinaz S, Belluscio BA, Malone P, van der Veen J, Hallett M, Horovitz SG. Role of the sensorimotor cortex in tourette syndrome using multimodal imaging. Human Brain Mapping 2014, 35: 5834-5846. PMID: 25044024, PMCID: PMC4776755, DOI: 10.1002/hbm.22588.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidSensorimotor cortexTourette syndromeFunctional magnetic resonance imagingBeta band powerH-Magnetic Resonance SpectroscopyState functional connectivity patternsMagnetic resonance imagingFunctional connectivity patternsMost patientsProcessing disturbancesSensory processing disturbanceVocal ticsLimbic inputsMotor phenomenaPremonitory sensationsPatientsResonance imagingTic generationNeuropsychiatric disordersAnterior insulaBand powerBeta oscillationsBeta activitySyndrome