Direct and Indirect Contribution of Human Embryonic Stem Cell–Derived Hepatocyte-Like Cells to Liver Repair in Mice
Woo D, Kim S, Lim H, Heo J, Park H, Kang G, Kim S, You H, Hoeppner D, Kim Y, Kwon H, Choi T, Lee J, Hong S, Song K, Ahn E, Chenoweth J, Tesar P, McKay R, Kim J. Direct and Indirect Contribution of Human Embryonic Stem Cell–Derived Hepatocyte-Like Cells to Liver Repair in Mice. Gastroenterology 2011, 142: 602-611. PMID: 22138358, DOI: 10.1053/j.gastro.2011.11.030.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersCarbon TetrachlorideCell DifferentiationCell ProliferationCell SeparationCells, CulturedChemical and Drug Induced Liver InjuryCoculture TechniquesDisease Models, AnimalEmbryonic Stem CellsHepatocytesHumansImmunohistochemistryInduced Pluripotent Stem CellsLaser Capture MicrodissectionLithium ChlorideLiverLiver RegenerationMass SpectrometryMiceMice, Inbred BALB CMice, NudeMicroscopy, ElectronNeovascularization, PhysiologicPolymerase Chain ReactionProteomicsTime FactorsWound HealingConceptsHepatocyte-like cellsLiver repairLiver tissueCell replacementEndogenous liver regenerationAcute liver injuryDirect cell replacementHost liver tissueStem cellsLiver of miceIndocyanine green stainingHuman embryonic stem cell-derived cellsEmbryonic stem cell-derived cellsCell-derived signalsHost tissue repairStem cell-derived cellsStem cell-derived hepatocyte-like cellsCell-derived hepatocyte-like cellsLiver injuryCell-derived cellsPolymerase chain reactionCell graftsIntraperitoneal injectionHepatic featuresTrophic factors