2008
Inhibitory Effect of Tributyltin on Expression of Steroidogenic Enzymes in Mouse Testis
Kim S, Kim J, Han J, Yoon Y. Inhibitory Effect of Tributyltin on Expression of Steroidogenic Enzymes in Mouse Testis. International Journal Of Toxicology 2008, 27: 175-182. PMID: 18404541, DOI: 10.1080/10915810801977906.Peer-Reviewed Original ResearchConceptsInterstitial Leydig cellsSteroidogenic enzymesLeydig cellsImmature male miceSerum testosterone concentrationsTesticular developmentInhibition of steroidogenesisCholesterol side-chain cleavage enzymeSide-chain cleavage enzymeSteroid hormone productionGerm cellsTesticular germ cellsApoptotic germ cellsOral gavageMale miceSingle administrationTestosterone concentrationsHormone productionInhibitory effectSeminiferous tubulesAdverse effectsInduced apoptosisTBT exposureAcute toxicityCleavage enzyme
2007
Octylphenol reduces the expressions of steroidogenic enzymes and testosterone production in mouse testis
Kim S, Kim J, Lee H, Yoon Y. Octylphenol reduces the expressions of steroidogenic enzymes and testosterone production in mouse testis. Environmental Toxicology 2007, 22: 449-458. PMID: 17696135, DOI: 10.1002/tox.20280.Peer-Reviewed Original ResearchConceptsTestosterone productionSteroidogenic enzymesLeydig cellsMale miceTestosterone concentrationsJuvenile exposureDecreased testosterone productionAltered cholesterol metabolismSerum testosterone concentrationsAdult male micePositive Leydig cellsCholesterol side-chain cleavage enzymeCholesterol transport genesSide-chain cleavage enzymeInterstitial Leydig cellsSteroidogenic acute regulatory proteinAlteration of steroidogenesisPresent studyAcute regulatory proteinEstradiol valerateInhibits steroidogenesisCholesterol metabolismRT-PCR analysisP450scc proteinPotential mechanisms