Octylphenol reduces the expressions of steroidogenic enzymes and testosterone production in mouse testis
Kim S, Kim J, Lee H, Yoon Y. Octylphenol reduces the expressions of steroidogenic enzymes and testosterone production in mouse testis. Environmental Toxicology 2007, 22: 449-458. PMID: 17696135, DOI: 10.1002/tox.20280.Peer-Reviewed Original ResearchConceptsTestosterone productionSteroidogenic enzymesLeydig cellsMale miceTestosterone concentrationsJuvenile exposureDecreased testosterone productionAltered cholesterol metabolismSerum testosterone concentrationsAdult male micePositive Leydig cellsCholesterol side-chain cleavage enzymeCholesterol transport genesSide-chain cleavage enzymeInterstitial Leydig cellsSteroidogenic acute regulatory proteinAlteration of steroidogenesisPresent studyAcute regulatory proteinEstradiol valerateInhibits steroidogenesisCholesterol metabolismRT-PCR analysisP450scc proteinPotential mechanisms