2023
PD-1highCXCR5–CD4+ peripheral helper T cells promote CXCR3+ plasmablasts in human acute viral infection
Asashima H, Mohanty S, Comi M, Ruff W, Hoehn K, Wong P, Klein J, Lucas C, Cohen I, Coffey S, Lele N, Greta L, Raddassi K, Chaudhary O, Unterman A, Emu B, Kleinstein S, Montgomery R, Iwasaki A, Dela Cruz C, Kaminski N, Shaw A, Hafler D, Sumida T. PD-1highCXCR5–CD4+ peripheral helper T cells promote CXCR3+ plasmablasts in human acute viral infection. Cell Reports 2023, 42: 111895. PMID: 36596303, PMCID: PMC9806868, DOI: 10.1016/j.celrep.2022.111895.Peer-Reviewed Original ResearchConceptsAcute viral infectionTph cellsViral infectionCXCR3 expressionClinical outcomesHelper TSevere viral infectionsB cell helpBetter clinical outcomesProtective humoral immunityT cell-B cell interactionsKey immune responsesPlasmablast expansionB cell differentiationCell subsetsHumoral immunityCell helpImmune responseInterferon γPlasmablast differentiationB cellsPlasmablastsCell responsesInfectionCD4
2013
An altered relationship of influenza vaccine-specific IgG responses with T cell immunity occurs with aging in humans (P4293)
Lee N, Kang K, Shin M, Mohanty S, Belshe R, Montgomery R, Shaw A, Kang I. An altered relationship of influenza vaccine-specific IgG responses with T cell immunity occurs with aging in humans (P4293). The Journal Of Immunology 2013, 190: 123.10-123.10. DOI: 10.4049/jimmunol.190.supp.123.10.Peer-Reviewed Original ResearchT cell immunityMemory T cellsIgG responsesHI antibody titersT cellsAntibody titersMemory CD8Cell immunityHemagglutinin inhibition antibody titersDistinct T cell subsetsCytokine-producing capacityEffector memory CD8Frequency of CD4Inactivated influenza vaccineCentral memory cellsT cell subsetsSpecific IgG responseSerum IgG responsesPotent survivalIL-17Influenza vaccineSignificant morbidityCell subsetsElderly peopleProliferative capacity