2021
Spreading depression as an innate antiseizure mechanism
Tamim I, Chung D, de Morais A, Loonen I, Qin T, Misra A, Schlunk F, Endres M, Schiff S, Ayata C. Spreading depression as an innate antiseizure mechanism. Nature Communications 2021, 12: 2206. PMID: 33850125, PMCID: PMC8044138, DOI: 10.1038/s41467-021-22464-x.Peer-Reviewed Original ResearchConceptsFocal neocortical seizuresSystemic kainic acidCentral nervous systemVivo mouse modelAntiseizure mechanismsAntiseizure effectsSeizure generalizationFocal seizuresSD occurrenceNeocortical seizuresKainic acidBrain injuryMouse modelNervous systemSeizuresNeurological disordersProlonged depolarizationSDDepressionBicucullineMigraineInjury
2003
In Vivo Modulation of Hippocampal Epileptiform Activity with Radial Electric Fields
Richardson K, Gluckman B, Weinstein S, Glosch C, Moon J, Gwinn R, Gale K, Schiff S. In Vivo Modulation of Hippocampal Epileptiform Activity with Radial Electric Fields. Epilepsia 2003, 44: 768-777. PMID: 12790889, DOI: 10.1046/j.1528-1157.2003.35402.x.Peer-Reviewed Original ResearchMeSH KeywordsAmplifiers, ElectronicAnimalsDisease Models, AnimalElectric StimulationElectric Stimulation TherapyElectrodes, ImplantedElectronics, MedicalEpilepsyHippocampusHumansKainic AcidKindling, NeurologicMaleMembrane PotentialsMicroelectrodesRatsRats, Sprague-DawleySeizuresStereotaxic TechniquesConceptsElectric field modulationRadial electric fieldElectric fieldElectric field controlField modulationMicroelectrode pairsCharge deliveryControl systemElectrode geometryField controlSeizure onset detectionElectrodeElectric field stimulationElectronicsStimulation electrodesFieldFirst resultsNovel approachExperiments